p53 Family Members: p63 and p73

2007 ◽  
pp. 187-198
Author(s):  
Elsa R. Flores ◽  
Tyler Jacks
Keyword(s):  
Family Members ◽  
P53 Family

Interactions of gut epithelial barrier, microbiome and p53 family members – what is their impact on liver cirrhosis?

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89 ◽  
Author(s):  
L Wächter ◽  
M Haderer ◽  
E Aschenbrenner ◽  
K Pollinger ◽  
S Schlosser ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Family Members ◽  
Epithelial Barrier ◽  
P53 Family

scholarly journals Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Ananya Chakravarti ◽  
Heshani N Thirimanne ◽  
Savanna Brown ◽  
Brian R Calvi
Keyword(s):  
Quality Control ◽  
Family Members ◽  
P53 Gene ◽  
Genotoxic Stress ◽  
Oocyte Quality ◽  
Protein Isoforms ◽  
Dna Breaks ◽  
P53 Family ◽  
Dna Lesion ◽  
P53 Isoforms

p53 gene family members in humans and other organisms encode a large number of protein isoforms whose functions are largely undefined. Using Drosophila as a model, we find that a p53B isoform is expressed predominantly in the germline where it colocalizes with p53A into subnuclear bodies. It is only p53A, however, that mediates the apoptotic response to ionizing radiation in the germline and soma. In contrast, p53A and p53B are both required for the normal repair of meiotic DNA breaks, an activity that is more crucial when meiotic recombination is defective. We find that in oocytes with persistent DNA breaks p53A is also required to activate a meiotic pachytene checkpoint. Our findings indicate that Drosophila p53 isoforms have DNA lesion and cell type-specific functions, with parallels to the functions of mammalian p53 family members in the genotoxic stress response and oocyte quality control.

Differential regulation of transcription and induction of programmed cell death by human p53-family members p63 and p73

FEBS Letters ◽  
2002 ◽  
Vol 525 (1-3) ◽  
pp. 93-99 ◽  
Author(s):  
Sebastian Dietz ◽  
Karen Rother ◽  
Casimir Bamberger ◽  
Hartwig Schmale ◽  
Joachim Mössner ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Family Members ◽  
Differential Regulation ◽  
Regulation Of Transcription ◽  
P53 Family

scholarly journals δEF1 repressor controls selectively p53 family members during differentiation

Oncogene ◽  
2005 ◽  
Vol 24 (49) ◽  
pp. 7273-7280 ◽  
Author(s):  
Giulia Fontemaggi ◽  
Aymone Gurtner ◽  
Alexander Damalas ◽  
Antonio Costanzo ◽  
Yujiro Higashi ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family

scholarly journals Differences in the transactivation domains of p53 family members: a computational study

BMC Genomics ◽  
2010 ◽  
Vol 11 (Suppl 1) ◽  
pp. S5 ◽  
Author(s):  
Jagadeesh N Mavinahalli ◽  
Arumugam Madhumalar ◽  
Roger W Beuerman ◽  
David P Lane ◽  
Chandra Verma
Keyword(s):  
Computational Study ◽  
Family Members ◽  
P53 Family ◽  
Transactivation Domains

scholarly journals P53 Family Members Modulate the Expression of PRODH, but Not PRODH2, via Intronic p53 Response Elements

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e69152 ◽  
Author(s):  
Ivan Raimondi ◽  
Yari Ciribilli ◽  
Paola Monti ◽  
Alessandra Bisio ◽  
Loredano Pollegioni ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family ◽  
Response Elements ◽  
P53 Response

scholarly journals Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

Cell Cycle ◽  
2011 ◽  
Vol 10 (24) ◽  
pp. 4272-4279 ◽  
Author(s):  
David P. Lane ◽  
Arumugam Madhumalar ◽  
Alison P. Lee ◽  
Boon-Hui Tay ◽  
Chandra Verma ◽  
...  
Keyword(s):  
Family Members ◽  
Cartilaginous Fish ◽  
P53 Family

Cross Talk Between Oxidative Stress and p53 Family Members in Regulating Cancer

2021 ◽  
pp. 1-16
Author(s):  
Sumiran Kumar Gurung ◽  
Lokesh Nigam ◽  
Kunwar Somesh Vikramdeo ◽  
Neelima Mondal
Keyword(s):  
Oxidative Stress ◽  
Cross Talk ◽  
Family Members ◽  
P53 Family

scholarly journals p53 Family Members Regulate the Expression of the Apolipoprotein D Gene

2008 ◽  
Vol 284 (2) ◽  
pp. 872-883 ◽  
Author(s):  
Yasushi Sasaki ◽  
Hideaki Negishi ◽  
Ryota Koyama ◽  
Naoki Anbo ◽  
Kanae Ohori ◽  
...  
Keyword(s):  
Family Members ◽  
P53 Family ◽  
Apolipoprotein D

scholarly journals ASPP1 and ASPP2: Common Activators of p53 Family Members

2004 ◽  
Vol 24 (3) ◽  
pp. 1341-1350 ◽  
Author(s):  
Daniele Bergamaschi ◽  
Yardena Samuels ◽  
Boquan Jin ◽  
Sai Duraisingham ◽  
Tim Crook ◽  
...  
Keyword(s):  
Rna Interference ◽  
Tumor Growth ◽  
Target Genes ◽  
Family Members ◽  
Mutant P53 ◽  
P53 Family ◽  
P53 Target Genes

ABSTRACT We recently showed that ASPP1 and ASPP2 stimulate the apoptotic function of p53. We show here that ASPP1 and ASPP2 also induce apoptosis independently of p53. By binding to p63 and p73 in vitro and in vivo, ASPP1 and ASPP2 stimulate the transactivation function of p63 and p73 on the promoters of Bax, PIG3, and PUMA but not mdm2 or p21WAF-1/CIP1. The expression of ASPP1 and ASPP2 also enhances the apoptotic function of p63 and p73 by selectively inducing the expression of endogenous p53 target genes, such as PIG3 and PUMA, but not mdm2 or p21WAF-1/CIP1. Removal of endogenous p63 or p73 with RNA interference demonstrated that (16) the p53-independent apoptotic function of ASPP1 and ASPP2 is mediated mainly by p63 and p73. Hence, ASPP1 and ASPP2 are the first two identified common activators of all p53 family members. All these results suggest that ASPP1 and ASPP2 could suppress tumor growth even in tumors expressing mutant p53.

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