Tumor necrosis of primary malignancy affects survival and outcome in patients with liver metastases from neuroendocrine tumors

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
G Atanasov ◽  
I Tsvetkova ◽  
S Benjamin ◽  
A Andreou ◽  
F Klein ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumors ◽  
Tumor Necrosis ◽  
Primary Malignancy

scholarly journals Expression of the phosphorylated variant of the AKT1-kinase (p-AKT1) in well-differentiated pancreatic neuroendocrine tumors: immunohistochemical evaluation

2018 ◽  
Vol 46 (4) ◽  
pp. 314-322
Author(s):  
V. V. Delektorskaya ◽  
O. N. Solov'eva ◽  
G. Yu. Chemeris ◽  
Yu. I. Patyutko
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumors ◽  
Treatment Effectiveness ◽  
Disease Free Survival ◽  
Immunohistochemical Analysis ◽  
Pancreatic Neuroendocrine Tumors ◽  
Ki 67 ◽  
New Treatment ◽  
Well Differentiated ◽  
High Level

Background:Well-differentiated pancreatic neuroendocrine tumors (pNETs) represent a group of rare epithelial neoplasms with a highly variable clinical course. AKT1 is one of the most frequently activated protein kinases in pNETs, which promotes the tumor growth and is of interest as a prognostic factor and a target for new treatment approaches.Aim:To study the expression of the phosphorylated variant of AKT1-kinase (p-AKT1) in primary pNETs and their liver metastases and to correlate the results with various clinical and pathological parameters and the disease prognosis.Materials and methods:P-AKT1 expression was studied by the immunohistochemical analysis of the primary lesions and liver metastases in 52 pNETs patients.Results:A high level of cytoplasmic and/or nuclear immunoreactivity was detected in 24/52 of the primary pNETs (46.2%) and in 16/27 of their liver metastases (59.3%). p-AKT1 expression was observed in 3 (21.4%) of NET grade (G) 1, in 14 (46.7%) of NET G2, and in 7 (87.5%) of NET G3. p-AKT1 expression was more frequently identified in pNET G3 category and increased during the tumor progression in metachronous liver metastases, as compared to the corresponding primary tumor. In addition, p-AKT1 positivity was significantly associated with an increase of grade from G1 to G3 (p = 0.004), the Ki-67 index (p = 0.029), the pTNM stage (p = 0.0008), perineural invasion (p = 0.031) and a decrease in disease-free survival (p = 0.05).Conclusion:The results suggest that p-АКТ1 plays an important role in the pathogenesis of pNETs and may be an additional criterion for assessment of the prognosis and treatment effectiveness in this type of tumors.

Image-Guided Ablation of Neuroendocrine Tumor Liver Metastases

2019 ◽  
Vol 03 (01) ◽  
pp. 038-045
Author(s):  
J. Hinshaw ◽  
Kelli Moore ◽  
Monika Rastogi
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Patient Management ◽  
Potential Role ◽  
Heterogeneous Group ◽  
Treatment Algorithms ◽  
Image Guided ◽  
Over Time

AbstractNeuroendocrine tumors (NETs) are a heterogeneous group of neoplasms that require a multidisciplinary process to determine the most appropriate approach for patient management and therapy. Over time, the treatment algorithms have continuously evolved as the options have improved and changed. This manuscript reviews the current and potential role of image-guided ablation in the treatment of patients with metastatic NET to the liver. While some attention will be devoted to the basics of ablation, the focus will be on the role of image-guided ablation in these patients and issues specific to the treatment of NET's liver metastases with ablation.

Meta-analysis of Liver Resection Versus Nonsurgical Treatments for Pancreatic Neuroendocrine Tumors with Liver Metastases

2015 ◽  
Vol 23 (1) ◽  
pp. 244-249 ◽  
Author(s):  
Chun-hui Yuan ◽  
Jing Wang ◽  
Dian-rong Xiu ◽  
Ming Tao ◽  
Zhao-lai Ma ◽  
...  
Keyword(s):  
Liver Resection ◽  
Liver Metastases ◽  
Neuroendocrine Tumors ◽  
Meta Analysis ◽  
Pancreatic Neuroendocrine Tumors

Treatment of Liver Metastases in Patients with Digestive Neuroendocrine Tumors

2012 ◽  
Vol 16 (10) ◽  
pp. 1981-1992 ◽  
Author(s):  
Roberta Elisa Rossi ◽  
Sara Massironi ◽  
Matilde Pia Spampatti ◽  
Dario Conte ◽  
Clorinda Ciafardini ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumors

scholarly journals Injection of recombinant tumor necrosis factor directly into liver metastases: an experimental and clinical approach

1992 ◽  
Vol 10 (2) ◽  
pp. 91-97 ◽  
Author(s):  
Jan N. M. IJzermans ◽  
Marcel Scheringa ◽  
George P. van der Schelling ◽  
Rob A. Geerling ◽  
Richard L. Marquet ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Metastases ◽  
Tumor Necrosis ◽  
Clinical Approach ◽  
Recombinant Tumor Necrosis Factor ◽  
Necrosis Factor
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