Computers and Iatrocomplexities

1966 ◽  
Vol 05 (04) ◽  
pp. 167-171 ◽  
Author(s):  
L. E. Faer
Keyword(s):  
Twentieth Century ◽  
Cigarette Smoke ◽  
Environmental Pollutants ◽  
Genetic Composition ◽  
Koch’S Postulates ◽  
Lung Malignancies ◽  
Causative Agents ◽  
Disease Study ◽  
Multiple Etiology ◽  
Great Advance

Developments of disease hypotheses and conceptions of disease as philosophic entities have shown bursts of great advance. One just concluded includes emergence of bacteriology and virology culminating in Koch’s Postulates, which in the twentieth century were primary bases for disease study and colored all approaches to medicine.With recent extraordinary advances in technology, medicine faces great new obligations demanding fresh approaches and untrammeled thinking for solution of problems posed. It is clear that any approach to diseases and disabilities induced by exposures to environmental pollutants must take multiple etiology into account. For example, contributing to causation of lung malignancies one must list usual dusts, radioactivity, smog, auto exhausts, cigarette smoke and genetic composition. Consideration of plural factors in genesis of environmentally associated disease leads to the hypothesis of the incremental insult, a complex and difficult conception in which must be included provision for multiple causative agents, each contributing but a fraction toward total etiology^ Computers developed to their present refinement provide necessary tools for whatever complexity required to spawn and fructify hypotheses of inter-relating associations of incremental insults leading to pathology.

scholarly journals Levels of Cadmium (Cd) in Urine in Passive Smokers

2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Nurhayana Nurhayana
Keyword(s):  
Health Status ◽  
Cigarette Smoke ◽  
Experimental Research ◽  
Daily Life ◽  
Environmental Pollutants ◽  
Passive Smoker ◽  
Descriptive Research ◽  
Living Things ◽  
Status Occupation ◽  
Research Criteria

Smoking is a familiar activity in daily life. The existence of filters on cigarettes, causes the danger of cigarette smoke to be felt more by passive smokers. One of the content of cigarette smoke is cadmium (Cd) which is one of the environmental pollutants that are harmful and accumulate in the tissues of living things. The purpose of this study is to measure and describe the levels of Cadmium (Cd) in the urine of passive smokers in RT 03 RW 06 Gandekan Hamlet, Harjosari, Bawen District, Semarang Regency. Using observational (non-experimental) research design with descriptive research criteria. The number of samples of 12 urine from the community of RT 03 RW 06 Gandekan Hamlet, Harjosari, Bawen Subdistrict, Semarang Regency. The results of the examination of Cadmium Levels (Cd) on the 13 samples of passive smoker urine in gandekan RT 01 RW 06 Harjosari Subdistrict, Bawen Subdistrict, Semarang District received the highest level of 0.074 mg/L and the lowest result -0.005 mg/L. Differences in cadmium levels in the passive smoker urine were caused by several factors such as age, environment, health status, occupation, and consumption of antioxidants and milk. Cadmium (Cd) levels in the urine of all passive smokers were in the normal category (2mg/L).

Cigarette smoke-induced bronchoconstriction: causative agents and role of thromboxane receptors

1996 ◽  
Vol 81 (5) ◽  
pp. 2053-2059 ◽  
Author(s):  
Ju-Lun Hong ◽  
Lu-Yuan Lee
Keyword(s):  
Cigarette Smoke ◽  
Guinea Pigs ◽  
Bronchoalveolar Lavage Fluid ◽  
Smooth Muscles ◽  
Lavage Fluid ◽  
Phase Response ◽  
Second Phase ◽  
Causative Agents ◽  
Thromboxane Receptors

Hong, Ju-Lun, and Lu-Yuan Lee. Cigarette smoke-induced bronchoconstriction: causative agents and role of thromboxane receptors. J. Appl. Physiol. 81(5): 2053–2059, 1996.—Inhalation of cigarette smoke induces a biphasic bronchoconstriction in guinea pigs: the first phase is induced by a combination of cholinergic reflex and tachykinins, whereas the second phase involves cyclooxygenase metabolites (J.-L. Hong, I. W. Rodger, and L.-Y. Lee. J. Appl. Physiol. 78: 2260–2266, 1995). This study was carried out to further determine the causative agents in the smoke and the types of prostanoid receptors and endogenous prostanoids mediating the bronchoconstriction. Inhalation of 10 ml of high-nicotine cigarette smoke consistently elicited the biphasic bronchoconstriction in anesthetized and artificially ventilated guinea pigs. Pretreatment with hexamethonium (10 mg/kg iv) significantly reduced the first-phase bronchoconstriction but did not have any measurable effect on the second-phase response. In sharp contrast, gas-phase smoke did not elicit any bronchoconstrictive effect. Furthermore, when the animals were challenged with low-nicotine cigarette smoke, only a single second-phase response was evoked, accompanied by increases in thromboxane (Tx) B2 (a stable metabolite of TxA2), prostaglandin (PG) D2, PGF2α in the bronchoalveolar lavage fluid. The bronchoconstrictive response induced by low-nicotine smoke was completely prevented by pretreatment with SQ-29548 (0.3 mg/kg iv), a TxA2-receptor antagonist. These results indicate that 1) nicotine is the primary causative agent responsible for the first-phase bronchoconstriction and 2) nonnicotine smoke particulates evoke the release of TxA2, PGD2, and PGF2α, which act on TxA2 receptors on airway smooth muscles and induce the second-phase response to cigarette smoke.

scholarly journals Twentieth-century changes in the genetic composition of Swedish field pea metapopulations

Heredity ◽  
2012 ◽  
Vol 110 (4) ◽  
pp. 338-346 ◽  
Author(s):  
M W Leino ◽  
E Boström ◽  
J Hagenblad
Keyword(s):  
Twentieth Century ◽  
Field Pea ◽  
Genetic Composition

scholarly journals Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer

2012 ◽  
Vol 302 (11) ◽  
pp. L1150-L1158 ◽  
Author(s):  
Thu P. Huynh ◽  
Vei Mah ◽  
Valerie B. Sampson ◽  
David Chia ◽  
Michael C. Fishbein ◽  
...  
Keyword(s):  
Atpase Activity ◽  
Lung Adenocarcinoma ◽  
Cigarette Smoke ◽  
Smoking Status ◽  
Immunohistochemical Analysis ◽  
Tumor Grade ◽  
Smoking History ◽  
Lung Carcinogenesis ◽  
Lung Malignancies

Diminished Na,K-ATPase expression has been reported in several carcinomas and has been linked to tumor progression. However, few studies have determined whether Na,K-ATPase function and expression are altered in lung malignancies. Because cigarette smoke (CS) is a major factor underlying lung carcinogenesis and progression, we investigated whether CS affects Na,K-ATPase activity and expression in lung cell lines. Cells exposed to CS in vitro showed a reduction of Na,K-ATPase activity. We detected the presence of reactive oxygen species (ROS) in cells exposed to CS before Na,K-ATPase inhibition, and neutralization of ROS restored Na,K-ATPase activity. We further determined whether Na,K-ATPase expression correlated with increasing grades of lung adenocarcinoma and survival of patients with smoking history. Immunohistochemical analysis of lung adenocarcinoma tissues revealed reduced Na,K-ATPase expression with increasing tumor grade. Using tissue microarray containing lung adenocarcinomas of patients with known smoking status, we found that high expression of Na,K-ATPase correlated with better survival. For the first time, these data demonstrate that CS is associated with loss of Na,K-ATPase function and expression in lung carcinogenesis, which might contribute to disease progression.

Some Polish Composers of To-Day

Tempo ◽  
1948 ◽  
pp. 25-28
Author(s):  
Andrzej Panufnik
Keyword(s):  
Twentieth Century ◽  
Fertile Soil ◽  
Early Twentieth Century ◽  
Progressive Group ◽  
Karol Szymanowski

It is ten years since KAROL SZYMANOWSKI died at fifty-four. He was the most prominent representative of the “radical progressive” group of early twentieth century composers, which we call “Young Poland.” In their manysided and pioneering efforts they prepared the fertile soil on which Poland's present day's music thrives.

Polychlorinated biphenyl induced hepatocyte alterations

1987 ◽  
Vol 45 ◽  
pp. 716-717
Author(s):  
D.N. Collins ◽  
J.N. Turner ◽  
K.O. Brosch ◽  
R.F. Seegal
Keyword(s):  
Lipid Droplets ◽  
Wistar Rats ◽  
Homovanillic Acid ◽  
Polychlorinated Biphenyl ◽  
Corn Oil ◽  
Environmental Pollutants ◽  
Short Term ◽  
Pcb Congeners ◽  
Urinary Levels ◽  
The Brain

Polychlorinated biphenyls (PCBs) are a ubiquitous class of environmental pollutants with toxic and hepatocellular effects, including accumulation of fat, proliferated smooth endoplasmic recticulum (SER), and concentric membrane arrays (CMAs) (1-3). The CMAs appear to be a membrane storage and degeneration organelle composed of a large number of concentric membrane layers usually surrounding one or more lipid droplets often with internalized membrane fragments (3). The present study documents liver alteration after a short term single dose exposure to PCBs with high chlorine content, and correlates them with reported animal weights and central nervous system (CNS) measures. In the brain PCB congeners were concentrated in particular regions (4) while catecholamine concentrations were decreased (4-6). Urinary levels of homovanillic acid a dopamine metabolite were evaluated (7).Wistar rats were gavaged with corn oil (6 controls), or with a 1:1 mixture of Aroclor 1254 and 1260 in corn oil at 500 or 1000 mg total PCB/kg (6 at each level).

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