Fundamentals of Controlled Clinical Trials

1962 ◽  
Vol 01 (01) ◽  
pp. 1-5 ◽  
Author(s):  
P. Martini
Keyword(s):  
The Other ◽  
Basic Rule ◽  
Double Blind ◽  
Other Hand ◽  
Long Term Treatment ◽  
The One ◽  
The Individual ◽  
Therapeutic Research ◽  
Secondary Causes

SummaryThe result of therapeutic research should, if possible, also benefit the recovery of the patient. The basic rule for every therapeutic-clinical trial must involve a comparison of therapeutic approaches. In acute conditions, such as acute infectious diseases, infarcts, etc., comparisons should be made between two or more groups: the collective therapeutic comparison, i.e. the between-patients trial. The formation of groups to be compared one with the other can be justified only if one is reasonably sure that a pathogenic condition does indeed exist. In chronic diseases, which extend essentially unchanged over a lengthy period but are nevertheless reversible, therapeutic comparisons may be made between two or more time intervals within the course of the disease in the same individual. This type of therapeutic trial rests primarily upon a (refined!) type of specious reasoning and secondarily upon modified statistics: the individual therapeutic comparison, i.e. the within-patient trial. The collective therapeutic comparison on the one hand and the individual therapeutic comparison on the other hand overlap somewhat in scope. The immediate therapeutic effect is not always an indication of its true value which may become evident only upon long-term treatment. The short-term trials of therapeutic regimens in an individual must, therefore, be frequently supplemented by long-term trials which can only be carried out by comparing two groups. For many clinical investigations the joint efforts of numerous hospitals are, therefore, absolutely necessary.The second basic rule of therapeutic research is the elimination of secondary causes. The difficulties introduced by these secondary considerations are far greater in therapeutic trials carried out on ambulatory patients than has hitherto been realized. In order to remove subjective secondary causes, the author demanded in 1931 the use of hidden or illusory media (placebos, dummies), i.e. unconscious causative agents. The double blind procedure is indispensible in all experiments, especially where psychological processes and problems are of foremost importance. Therefore, it is absolutely necessary that convincing tests be finally carried out with the double blind procedure on the one hand and the simple blind procedure on the other hand in order to determine the range and limitations of both. Therapeutic research of the future is threatened by the hazard of self-satisfaction which produces a sense of accomplishment merely as the result of obeying formal conditions and of following formal standards of accuracy.

Radioimmunotherapy for treatment of acute myeloid leukaemia and myelodysplastic syndrome

2005 ◽  
Vol 44 (03) ◽  
pp. 107-117
Author(s):  
R. G. Meyer ◽  
W. Herr ◽  
A. Helisch ◽  
P. Bartenstein ◽  
I. Buchmann
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Primary Tumour ◽  
The Other ◽  
Haematopoietic Stem Cell ◽  
Other Hand ◽  
Primary Reduction ◽  
The One ◽  
Acute Myeloid

SummaryThe prognosis of patients with acute myeloid leukaemia (AML) has improved considerably by introduction of aggressive consolidation chemotherapy and haematopoietic stem cell transplantation (SCT). Nevertheless, only 20-30% of patients with AML achieve long-term diseasefree survival after SCT. The most common cause of treatment failure is relapse. Additionally, mortality rates are significantly increased by therapy-related causes such as toxicity of chemotherapy and complications of SCT. Including radioimmunotherapies in the treatment of AML and myelodyplastic syndrome (MDS) allows for the achievement of a pronounced antileukaemic effect for the reduction of relapse rates on the one hand. On the other hand, no increase of acute toxicity and later complications should be induced. These effects are important for the primary reduction of tumour cells as well as for the myeloablative conditioning before SCT.This paper provides a systematic and critical review of the currently used radionuclides and immunoconjugates for the treatment of AML and MDS and summarizes the literature on primary tumour cell reductive radioimmunotherapies on the one hand and conditioning radioimmunotherapies before SCT on the other hand.

Laughter on the Fringes

2019 ◽  
Author(s):  
Anna Peterson
Keyword(s):  
The Other ◽  
Literary Canon ◽  
Autobiographical Writing ◽  
Treasure Trove ◽  
Old Comedy ◽  
Other Hand ◽  
Aggressive Humor ◽  
The One ◽  
The Individual ◽  
The Impact

This book examines the impact that Athenian Old Comedy had on Greek writers of the Imperial era. It is generally acknowledged that Imperial-era Greeks responded to Athenian Old Comedy in one of two ways: either as a treasure trove of Atticisms, or as a genre defined by and repudiated for its aggressive humor. Worthy of further consideration, however, is how both approaches, and particularly the latter one that relegated Old Comedy to the fringes of the literary canon, led authors to engage with the ironic and self-reflexive humor of Aristophanes, Eupolis, and Cratinus. Authors ranging from serious moralizers (Plutarch and Aelius Aristides) to comic writers in their own right (Lucian, Alciphron), to other figures not often associated with Old Comedy (Libanius) adopted aspects of the genre to negotiate power struggles, facilitate literary and sophistic rivalries, and provide a model for autobiographical writing. To varying degrees, these writers wove recognizable features of the genre (e.g., the parabasis, its agonistic language, the stage biographies of the individual poets) into their writings. The image of Old Comedy that emerges from this time is that of a genre in transition. It was, on the one hand, with the exception of Aristophanes’s extant plays, on the verge of being almost completely lost; on the other hand, its reputation and several of its most characteristic elements were being renegotiated and reinvented.

scholarly journals The role of SMEs in innovation-oriented economic development

2017 ◽  
pp. 95-99
Author(s):  
Tamás Köpeczi-Bócz ◽  
Mónika Lőrincz
Keyword(s):  
Rural Areas ◽  
Tertiary Education ◽  
National Level ◽  
Business Environment ◽  
The Other ◽  
Sectoral Structure ◽  
Other Hand ◽  
Knowledge Intensive ◽  
The One

Both at European and national level tertiary and quaternary sectors are concentrated in the metropolitan centre. In the rural areas only the sites of such sectors can be found the premises of which temporarily transform the sectoral structure of these areas, but from the regional development aspect they did not prove to be an effective strategy.The European Commission is now focusing on growth from innovation, which could become the driving force behind productivity growth and the economy’s long-term trend. The innovation-oriented economic development’s key players are on the one hand the knowledge-intensive enterprises, on the other hand the universities. Tertiary education can play a role – among others – in shaping and creating the development of knowledge intensive business environment and conditions, on the other hand it can assist the development of network contacts – another precondition of employment growth.

scholarly journals The Quranic Treatment of Extremism

2021 ◽  
Vol 17 (01) ◽  
pp. 41-74
Author(s):  
Ahmed Abdellah Ahmed Alhossany
Keyword(s):  
The Other ◽  
Other Hand ◽  
Holy Quran ◽  
The Holy Quran ◽  
The One ◽  
The Individual

This study deals with the Quranic treatment of extremism in terms of extremisms concept and semantics, types, causes, images,  and the Quranic approach in its treatment, and we try to link the Muslim to the Quran approach in the treatment of extremism as a problem which the individual and the old and new society suffer; Because extremism can be transformed from mere idea to apparent behavior while demonstrating that extremism in fact transcends the rules of law and divine orders, it is excessive in the commitment to religion on the one hand or negligence in adhering to it, on the other hand, it is not always concerned with bringing the matter but also enters into relinquishing. In addition to the need to be warned that extremism is a method of religiosity and not religion itself, and Islam with its centrist approach rejects such practices and seeks to address them through the curriculum of the Holy Quran

scholarly journals La movilización de los pensionistas en España como proceso de construcción y aprendizaje de una nueva identidad colectiva

2021 ◽  
pp. 97-124
Author(s):  
Manuel Jiménez Sánchez ◽  
Raúl Álvarez Pérez ◽  
Gomer Betancor Nuez
Keyword(s):  
Collective Identity ◽  
Learning Processes ◽  
The Other ◽  
Analytical Strategy ◽  
Collective Identification ◽  
The Great Recession ◽  
Other Hand ◽  
Mass Protest ◽  
The One ◽  
The Individual

El movimiento de los pensionistas en 2018 supuso la primera movilización multitudinaria basada en una identidad colectiva de personas mayores en España, y mostró una capacidad de contestación popular sin precedentes en el tema de las pensiones. Este trabajo indaga en el proceso de configuración de la identidad colectiva como estrategia analítica que permite entender la aparición y la naturaleza (exitosa) de la movilización. Siguiendo la conceptualización de Melucci, este proceso se analiza desde una doble perspectiva. Por un lado, como estrategia de actores colectivos que persiguen articular la contestación popular a la política de pensiones puestas en marcha durante la Gran Recesión. Aquí, el análisis se centra en identificar el proceso organizativo en el que se sientan las bases identitarias del movimiento, y que se extenderían con éxito en la fase posterior de contestación masiva. Por otro lado, se presta atención a la naturaleza de la identificación entre los propios pensionistas como resultado de procesos de aprendizaje durante sus experiencias de movilización. Para la primera perspectiva, el trabajo se basa en informaciones obtenidas en noticias de prensa sobre las actividades de protesta y en documentos producidos por las organizaciones del movimiento. La perspectiva individual de los participantes se fundamenta en el análisis de los discursos obtenidos en entrevistas personales focalizadas a participantes. Este doble enfoque, como estrategia organizativa intencionada y como proceso de aprendizaje durante la experiencia de la movilización, ofrece informaciones clave para comprender no solo el proceso, inédito en España, de construcción de una voz propia de los pensionistas sino también para indagar en los procesos de aprendizaje y cambio actitudinal que implican para los participantes corrientes. En un sentido más amplio, esta estrategia de análisis permite igualmente, por un lado, ubicar el proceso de movilización de los pensionistas en una trayectoria temporal más amplia de contestación popular y, en particular, vincularlo a los legados del ciclo de movilización que protagonizó el 15-M. Por otro lado, también permite destacar esos procesos de contestación como espacios de aprendizaje en los que se modelan actitudes, valores y demás elementos de la cultura de protesta. The pensioners' movement in 2018 was the first mass mobilization based on a collective identity of older people in Spain, and showed an unprecedented capacity for popular contestation on the issue of pensions. This paper inquires into the process of collective identity configuration as an analytical strategy that allows us to understand the emergence and (successful) nature of the mobilisation. Following Melucci's conceptualization, this process is analysed from a double perspective. On the one hand, as a strategy of collective actors seeking to articulate popular contestation to the pension policies implemented during the Great Recession. Here, the analysis focuses on identifying the organizational process in which the identity bases of the movement are established and, which were successfully extended in the subsequent phase of mass protest. On the other hand, attention is paid to the nature of the collective identification among pensioners themselves as result of learning processes during their protest experiences. The analysis of the organizational configuration of the movement is based on information obtained from press reports on the protest activities and documents produced by the movement's organizations. The individual perspective of the participants relies on the analysis of the discourses obtained in focused interviews with participants. This dual approach, as an intentional organizational strategy and as a learning process during the mobilization experience, provides key information to understand not only the process, unprecedented in Spain, of building a voice for pensioners, but also to investigate the learning processes and attitudinal change involved for ordinary participants. More broadly, it also allows, on the one hand, to place the process of mobilization of pensioners in a broader temporal trajectory of popular contestation and, in particular, to link it to the legacies of the cycle of mobilization in the wake of the 15-M movement. On the other hand, it also allows us to observe protest as learning spaces in which attitudes, values, and other elements of the culture of protest are modelled.

Herbert Mac Cabe’s Philosophical Anthropology

Politeia ◽  
2019 ◽  
Vol 1 (4) ◽  
pp. 238-260
Author(s):  
Franco Manni ◽  
Keyword(s):  
Philosophical Anthropology ◽  
External World ◽  
The Other ◽  
Human Being ◽  
Language System ◽  
Other Hand ◽  
The One ◽  
The Individual ◽  
The Brain ◽  
Individual Human

From the ideas of Aristotle, De Saussure and Wittgenstein, philosopher Herbert McCabe elaborated an original anthropology. 'Meaning' means: the role played by a part towards the whole. Senses are bodily organs and sensations allow an animal to get fragments of the external world which become 'meaningful' for the behaviour of the whole animal Besides sensations, humans are ‘linguistic animals’ because through words they are able to 'communicate', that is, to share a peculiar kind of meanings: concepts. Whereas, sense-images are stored physically in our brain and cannot be shared, even though we can relate to sense-images by words (speech coincides with thought). However, concepts do not belong to the individual human being qua individual, but to an interpersonal entity: the language system. Therefore, on the one hand, to store images is a sense-power and an operation of the brain, whereas the brain (quite paradoxically!) is not in itself the organ of thought. On the other hand, concepts do not exist on their own.

Translanguaging and linguistic landscapes

2015 ◽  
Vol 1 (1-2) ◽  
pp. 54-74 ◽  
Author(s):  
Durk Gorter ◽  
Jasone Cenoz
Keyword(s):  
The Other ◽  
Holistic View ◽  
Linguistic Resources ◽  
School Settings ◽  
Other Hand ◽  
San Sebastian ◽  
The One ◽  
The Individual ◽  
Neighborhood Level

In this article we discuss the concept of translanguaging in relation to a holistic view of linguistic landscapes that goes beyond the analysis of individual signs. On the one hand, we look at instances of multilingual signage as a combination of linguistic resources. On the other hand, at the neighborhood level the individual signs combine, alternate and mix to shape linguistic landscapes as a whole. We expand our “Focus on Multilingualism” approach from school settings to the multilingual cityscape. One bookshop and its surrounding neighborhoods in Donostia-San Sebastián illustrate how readers navigate between languages and go across linguistic borders. Through translanguaging we foreground the co-occurrence of different linguistic forms, signs and modalities. At the level of neighborhood emerges the space in which translanguaging goes outside the scope of single signs and separate languages. We conclude that translanguaging is an approach to linguistic landscapes that takes the study of multilingualism forward.

Religion and Constitutional Practices in Asia: Five ‘Cs’ for Reflection

2018 ◽  
Vol 13 (2) ◽  
pp. 219-225
Author(s):  
Arif A JAMAL
Keyword(s):  
Case Studies ◽  
Comparative Law ◽  
The Other ◽  
Special Issue ◽  
Other Hand ◽  
Short Commentary ◽  
Five Cs ◽  
The One ◽  
The Individual

AbstractIn considering the articles in this Special Issue, I am struck by the importance of a set of factors that, in my view, both run through the articles like a leitmotif, as well as shape the major ‘take away’ lesson(s) from the articles. In this short commentary, I elaborate on these factors and the lesson(s) to take from them through five ‘Cs’: context; complexity; contestation; the framework of constitutions; and the role of comparative law. The first three ‘Cs’ are lessons from the case studies of the articles themselves, while the second two ‘Cs’ are offered as lessons to help take the dialogue forward. Fundamentally, these five ‘Cs’ highlight the importance of the articles in this Special Issue and the conference from which they emerged on the one hand, while on the other hand, also making us aware of what are the limits of what we should conclude from the individual articles. In other words, taken together, the five ‘Cs’ are, one might say, lessons about lessons.

Aspects of Marriage in Three South-western Villages

1992 ◽  
Vol 130 ◽  
pp. 323-337 ◽  
Author(s):  
Stevan Harrell
Keyword(s):  
Rural China ◽  
The Other ◽  
Other Hand ◽  
The Family ◽  
The One

In their effect on marriage and the family, as in so many other domains, the reforms can be seen as having a dual thrust. On the one hand, by giving the land in long-term leases back to the family, and allowing it to invest in a variety of small and medium-sized ventures, they have restored something like the situation in rural China before the collectivization of 1956, when the family estate was the source of income and investment in opportunity for most rural Chinese. On the other hand, the reforms have been undertaken explicitly in the name of modernization, and the increases in both agricultural and rural industrial yields, along with the rise in household entrepreneurship, have taken China in some ways even further from the feudalism of pre-revolutionary days than it was during the collective era.

On the capture of interstellar matter by stars

1940 ◽  
Vol 36 (3) ◽  
pp. 314-322 ◽  
Author(s):  
R. d'E. Atkinson
Keyword(s):  
Radial Velocity ◽  
The Other ◽  
Interstellar Matter ◽  
Centre Of Gravity ◽  
Compelling Reason ◽  
Other Hand ◽  
The Mean ◽  
The One ◽  
The Individual ◽  
Capture Radius

The derivation given by Hoyle and Lyttleton for an accretion formula proposed by them is examined. A number of arguments against its validity are put forward, especially that on the one hand their capture radius depends on the theorem that if the velocity of certain masses of gas after collision is less than the velocity of escape at the point, they will not in fact escape, while on the other hand it is clear (and is now admitted) that the gas cannot in fact move with this velocity at all. It is also shown that since, ex hypothesi, the individual molecules will all, on the average, retain their hyperbolic velocities, there is not the compelling reason for their capture that there appeared to be in Hoyle and Lyttleton's argument, where only the mean radial velocity of the centre of gravity of the mass was considered. Further, it seems improbable that the temperature of the interstellar matter can be low enough for the initial assumptions of their theory to hold.

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