ALTERED COAGULATION IN CEREBRAL ISCHEMIA PATIENTS

1987 ◽  
Author(s):  
M Fisher ◽  
R Francis
Keyword(s):  
Cerebral Ischemia ◽  
Platelet Activation ◽  
Fibrinolytic Activity ◽  
Disease Patient ◽  
Fibrinopeptide A ◽  
Transient Ischemic Attacks ◽  
Initial Examination ◽  
Acute Patients ◽  
Normal Controls ◽  
Age And Sex

We investigated coagulation changes in a group of patients with cerebral ischemia, ranging from transient ischemic attacks to cerebral infarction. Patients were studied acutely (within 72 hours of onset of ischemia) and again approximately 2 months following the initial examination. We evaluated platelet activation, fibrin generation, and fibrinolysis by measuring plasma beta-thromboglobulin (BTG), fibrinopeptide A (FPA), and fibrinopeptide B-beta 1-42 (FPB), respectively. We compared measurements in cerebral ischemia patients with a group of age -and sex-matched neurological inpatients without vascular disease ("patient controls") and a similarly matched group of normal volunteers ("normal controls"). BTG levels for 90 patients studied acutely were not significantly different compared to 58 of the same patients studied 2 months later, 16.4 ± 11.3 ng/ml (mean ± SD) versus 17.5 ± 10.2 ng/ml. Both values were significantly increased (p< .05) compared to normal controls (12.2 ± 6.5 ng/ml, n = 44); patient controls (13.2 ± 7.6 ng/ml, n = 18) were not significantly different from normals. In contrast, FPA measurements were significantly increased in acute patients compared to normals (3.3 ± 5.8 versus 1.0 ± 1.7 ng/ml, p< .05) while FPA levels 2 months post-ischemia (0.6 ± 0.9 ng/ml) were no different than normals. FPB measurements were not significantly different among either acute patients (6.5 ± 2.4 pmol/ml) or patients 2 months post-ischemia (4.8 ± 1.5 pmol/ml) compared to normals (6.5 ± 1.8 pmol/ml).In summary, we have found, among cerebral ischemia patients, sustained increases in BTG, acute increases in FPA, and normal FPB. These findings are compatible with a model of cerebral ischemia consisting of acutely increased fibrin generation without concomitant increased fibrinolytic activity, superimposed on a background of increased platelet activation.

Fibrinopeptide A And Beta-Thromboglobulin Levels In Pre-Eclampsia And Hypertensive Pregnancy

1981 ◽  
Author(s):  
Jessie T Douglas ◽  
M Shah ◽  
G D O Lowe ◽  
C R M Prentice
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Platelet Activation ◽  
Thrombin Generation ◽  
Fibrinopeptide A ◽  
Intravascular Coagulation ◽  
Hypertensive Pregnancy ◽  
Platelet Release ◽  
Normal Controls

To evaluate thrombin generation and platelet activation in pre-eclampsia we have measured fibrinopeptide A (FPA) and beta-thromboglobulin (BTG) by radioimnunoassay in patients with this disorder and have compared them to patients with essential hypertension of pregnancy and normal controls. In 10 patients with pre-eclampsia significantly elevated levels were found of FPA (8.3 ± 4.3 ng/ul; mean normal 1.6 ± 0.8ng/μl, p<0.01) and of BTG (51.9 ± 16 ng/μl; mean normal 31 ± 16 ng/μl, p<0.01). In 5 patients with pregnancy and essential hypertension the levels of FPA (5.65 ± 2.2 ng/μl, p<0.01) were lower than in pre-eclampsia but were still significantly elevated. BTG (37 ± 2.5 ng/μl) was not significantly increased in these patients. These results are consistent with increased thrombin generation and platelet release in preeclampsia. In pre-eclampsia there is evidence of intravascular coagulation which occurs to a greater degree than in pregnant patients with comparable raised blood pressure due to essential hypertension. Serial FPA measurements may prove useful in monitoring the development and treatment of pre-eclampsia.

Fibrinopeptide A (FPA) Level and Fibrinogen Kinetics in Patients with Malignant Disease

1981 ◽  
Vol 46 (04) ◽  
pp. 706-709 ◽  
Author(s):  
Yasuhiro Yoda ◽  
Tsukasa Abe
Keyword(s):  
Fibrinolytic Activity ◽  
Turnover Rate ◽  
Malignant Disease ◽  
Major Determinant ◽  
Fibrinopeptide A

SummaryFPA level, fibrinogen turnover rate, and fibrinolytic activity were studied on 18 patients with malignant disease. It was found that the FPA levels were significantly elevated and were correlated with fibrinogen turnover rate (r=0.74, p<0.001) and FDP (r = 0.58, p<0.02). Estimated FPA turnover rate was also correlated with fibrinogen turnover rate (r = 0.70, p<0.001). These results suggest that fibrinogen catabolism in patients with malignant disease is related with thrombin proteolysis. However, ratios of 1/2 FPA turnover rate to fibrinogen turnover rate suggest that intravascular thrombin proteolysis is not the major determinant of fibrinogen catabolism. It is suspected that extravascular thrombin proteolysis is responsible for the elevation of plasma FPA level which is correlated with acceleration of fibrinogen catabolism.

HOMOZYGOUS FACTOR XII CONGENITAL DEFICIENCY: STUDY OF 10 NEW FAMILIES.

1987 ◽  
Author(s):  
G Castaman ◽  
F Rodeghiero ◽  
M Ruggeri
Keyword(s):  
Fibrinolytic Activity ◽  
Normal Values ◽  
Common Finding ◽  
Factor Xii ◽  
Normal Range ◽  
Congenital Deficiency ◽  
Fibrin Plate ◽  
Sporadic Cases ◽  
Laboratory Investigations ◽  
Normal Controls

Sporadic cases of thromboembolic events have been reported in patients with congenital factor XII deficiency and a relationship with a reduced intrinsic fibrinolysis has been suggested.We report here the results of clinical and laboratory investigations in 10 new families comprising 15 homozygotes (age 16-72) and 14 heterozygotes (age 18-65).In homozygotes, kaolin-activated-PTT was indefinitely prolonged and F XII activity and antigen were undetectable, whereas functional assays . of high molecular weight kininogen ahd kallikrein yielded normal values. Intrinsic fibrinolytic activity - assayed on fibrin plate by measuring lysis zones determined i. by euglobulin fraction, obtained in presence of dextran sulphate and flufenamate (Blood activator inventory test, Kluft 1979) - was reduced in all homozygous pts. to about 50% of normal (range 15-70%; normal range 80-120%); normal values were observed in all heterozygotes. Basal extrinsic fibrinolytic activity (measured after addition of Cl-inhibitor) was absent or minimal as in normal controls. None of our patients showed evidence of thrombotic diathesis.In conclusion, our study demonstrates that a reduced intrinsic fibrinolysis, as assayed by blood activator inventory test, is a common finding in F XII deficiency. The absence of thrombotic diathesis in our cases suggests that, this defect is probably devoid of any clinical significance.

Lateral cephalometric analysis of children with otitis media with effusion: A comparison with age and sex matched controls

1991 ◽  
Vol 105 (2) ◽  
pp. 71-77 ◽  
Author(s):  
A. R. Maw ◽  
I. M. Smith ◽  
G. N. Lance
Keyword(s):  
Soft Tissue ◽  
Otitis Media ◽  
Otitis Media With Effusion ◽  
Cephalometric Analysis ◽  
Linear Dimensions ◽  
Normal Controls ◽  
Age And Sex

AbstractPrevious reports from this department have established significant differences in the morphology of the nasopharynx between patients with otitis media with effusion (OME) and normal controls. This study has used lateral cephalometric analysis to investigate these differences in greater detail.Skeletal and soft tissue measurements were recorded in 50 patients with bilateral OME and were compared with 50 age and sex matched normal controls.Various points were plotted enabling 23 different linear dimensions and three angles in and around the nasopharynx to be compared. The results show significant differences between the two groups in the skeletal and soft tissue dimensions of the nasopharynx. The children with OME have a smaller nasopharynx with a suggestion that this may be due to a difference both in the rate and timing of growth.

Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats

2018 ◽  
Vol 106 ◽  
pp. 805-812 ◽  
Author(s):  
Yun-yi Yan ◽  
Lu-yao Ao ◽  
Lin Zhou ◽  
Cheng-yuan Li ◽  
Wei-rong Fang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Platelet Activation ◽  
Thrombus Formation ◽  
Therapeutic Effects

Platelet Dysfunction in Migraine: Effect of Self-Medication with Aspirin

1976 ◽  
Vol 36 (02) ◽  
pp. 319-324 ◽  
Author(s):  
Sunanda V. Deshmukh ◽  
John Stirling Meyer ◽  
Richard J. Mouche
Keyword(s):  
Platelet Aggregation ◽  
The Other ◽  
Platelet Inhibitors ◽  
Platelet Dysfunction ◽  
Self Medication ◽  
History Of ◽  
Platelet Aggregates ◽  
The Mean ◽  
Normal Controls ◽  
Age And Sex

SummaryCirculating microembolic index (CMI) was determined by drawing one blood sample into EDTA-formalin and the other into DTA alone in patients with migraine and compared with matched normal controls. Platelet aggregates, if any, are fixed in EDTA-formalin but dis- aggregated by EDTA. Ratios of these two counts approximate “unity” in normals and are proportionately less than unity, depending on the number of platelet aggregates. 26 untreated migraineurs and 19 migraineurs with history of self-medication with aspirin taken within 72 hours of the test, were studied in headache-free intervals. Results were compared with those from 20 healthy, age and sex matched volunteers, without migraine, who were medication- free for at least one week. Mean CMI in untreated migraineurs (0.77±0.03 SEM) was significantly lower than the mean in normal controls (0.94±0.02, p. <0.002). Migraineurs with selfadministration of aspirin had mean CMI of 0.88±0.02, differing significantly from untreated migraineurs (p <0.01) but not from normal controls (0.1<p<0.2). Results suggest excessive platelet aggregation in migraineurs which tends to be corrected by treatment with platelet inhibitors such as aspirin.

The Effect of Diabetes Regulation on Platelet Release, Fibrinolysis and Coagulation Tests, Before and After Stimulation with DDAVP

1985 ◽  
Vol 53 (01) ◽  
pp. 118-121 ◽  
Author(s):  
J H v d Knaap ◽  
A C de Boer ◽  
M A G Pannebakker ◽  
W van Heerde ◽  
G J H den Ottolander
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Control ◽  
Fibrinolytic Activity ◽  
Good Control ◽  
Phase Iii ◽  
Coagulation Tests ◽  
Before And After ◽  
Patients With Diabetes ◽  
Baseline Values ◽  
Normal Controls

SummaryIn this longitudinal study we measured β-TG, PF4, fibrinolytic activity (extrinsic and euglobulin fraction), fibrinogen, FVIII RAg and FVIII Rcof before and after i.v. DDAVP (FPA was only measured before DDAVP) in 20 patients with diabetes mellitus. These parameters were measured on three occasions: phase I: during disregulation, phase II: after three weeks of strict control, phase III: after nine weeks of good control. Twenty-two healthy volunteers served as normal controls.No significant differences related to metabolic control were found for β-TG, PF4, FPA and fibrinogen. There was no change after i.v. DDAVP administration. Fibrinolytic activity showed a significant increase after i.v. DDAVP. Baseline values and post-DDAVP increase were not significantly different from our normal controls.FVIII RAg and FVIII Rcof were both significantly elevated in diabetes mellitus. Both increased significantly after DDAVP. The FVIII RAg release (ΔFVIII RAg) was significantly less in the diabetics. Fibrinolytic activity, FVIII RAg and FVIII Rcof are independent of the degree of metabolic control in patients with diabetes.

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