Analysis of the Effect of Musical Stimulation on Cortical Auditory Evoked Potentials

Introduction Cortical auditory evoked potentials (CAEPs) are bioelectric responses that occur from acoustic stimulations, and they assess the functionality of the central auditory system. Objective The objective of the present study was to analyze the effect of musical stimulation on CAEPs. Methods The sample consisted of 42 healthy female subjects, aged between 18 and 24 years, divided into two groups – G1: without musical stimulation prior to the CAEP examination; and G2: with stimulation prior to the examination. In both groups, as a pre-collection procedure, the complete basic audiological evaluation was performed. For the musical stimulation performed in G2, we used an MP4 player programmed to play Pachelbel's “Canon in D Major” for five minutes prior to the CAEP examination. To analyze the effect on the groups, the ear side and the ide–group interaction , a mixed analysis of variance (ANOVA) of repeated measures was performed. Box M test and Mauchly sphericity test were also performed. Results Test differences were considered statistically significant when the p-value was < 0.05 (5%). Thus, it was possible to observe that there was a statistically significant difference of the P2 component characterized by the decrease in the amplitude of response in the left ear in G2 when comparing the responses of CAEP with and without prior musical stimulation. Conclusion The result of the present study enabled us to conclude that there was a change in the response of CAEPs with musical stimulation.

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New possibility for measuring the cortical auditory evoked potentials: the HEARLab

Orvosi Hetilap ◽

10.1556/oh.2014.29992 ◽

2014 ◽

Vol 155 (38) ◽

pp. 1524-1529

Author(s):

Ádám Bach ◽

Ferenc Tóth ◽

Vera Matievics ◽

József Géza Kiss ◽

József Jóri ◽

...

Keyword(s):

Clinical Practice ◽

Evoked Potentials ◽

Auditory System ◽

Hearing Aids ◽

Pure Tone ◽

Auditory Evoked Potentials ◽

Normal Hearing ◽

Speech Stimuli ◽

Novel Method ◽

Cortical Auditory Evoked Potentials

Introduction: Cortical auditory evoked potentials can provide objective information about the highest level of the auditory system. Aim: The purpose of the authors was to introduce a new tool, the “HEARLab” which can be routinely used in clinical practice for the measurement of the cortical auditory evoked potentials. In addition, they wanted to establish standards of the analyzed parameters in subjects with normal hearing. Method: 25 adults with normal hearing were tested with speech stimuli, and frequency specific examinations were performed utilizing pure tone stimuli. Results: The findings regarding the latency and amplitude analyses of the evoked potentials confirm previously published results of this novel method. Conclusions: The HEARLAb can be a great help when performance of the conventional audiological examinations is complicated. The examination can be performed in uncooperative subjects even in the presence of hearing aids. The test is frequency specific and does not require anesthesia. Orv. Hetil., 2014, 155(38), 1524–1529.

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The Detection of Infant Cortical Auditory Evoked Potentials (CAEPs) Using Statistical and Visual Detection Techniques

Journal of the American Academy of Audiology ◽

10.3766/jaaa.21.5.6 ◽

2010 ◽

Vol 21 (05) ◽

pp. 347-356 ◽

Cited By ~ 36

Author(s):

Lyndal Carter ◽

Maryanne Golding ◽

Harvey Dillon ◽

John Seymour

Keyword(s):

Evoked Potentials ◽

Repeated Measures ◽

Auditory Evoked Potentials ◽

Sensitivity Index ◽

Screening Programs ◽

Hotelling's T2 ◽

Hotelling’S T2 ◽

Response Detection ◽

Cortical Auditory Evoked Potentials ◽

Experienced Examiner

Background: With the advent of newborn hearing screening programs, the need to verify the fit of hearing aids in young infants has increased. The recording of cortical auditory evoked potentials (CAEPs) for this purpose is quite feasible, but rapid developmental changes that affect response morphology and the presence of electrophysiological noise can make subjective response detection challenging. Purpose: The purpose of this study was to investigate the effectiveness of an automated statistic versus experienced examiners in detecting the presence of infant CAEPs when stimuli were present and reporting the absence of CAEPs when no stimuli were present. Research Design: A repeated-measures design was used where infant-generated CAEPs were interpreted by examiners and an automated statistic. Study Sample: There were nine male and five female infants (mean age, 12 mo; SD, 3.4) who completed behavioral and electrophysiological testing using speech-based stimuli. Data Collection and Analysis: In total, 87 infant CAEPs were recorded to three sensation levels, 10, 20 and 30 dB relative to the behavioral thresholds and to nonstimulus trials. Three examiners were presented with these responses: (1) “in series,” where waveforms were presented in order of decreasing stimulus presentation levels, and (2) “nonseries,” where waveforms were randomized completely and presented as independent waveforms. The examiners were given no information about the stimulus levels and were asked to determine whether responses to auditory stimulation could be observed and their degree of certainty in making their decision. Data from the CAEP responses were also converted to multiple dependent variables and analyzed using Hotelling's T2. Results from both methods of response detection were analyzed using a repeated measures ANOVA (analysis of variance) and parameters of signal detection theory known as d-prime (d′) and the area under the receiver operating characteristic (ROC) curve. Results: Results showed that as the stimulus level increased, the sensitivity index, d′, increased for both methods of response detection, but neither reached the maximum possible d′ value with a sensation level of 30 dB. The examiners with the greatest experience and Hotelling's T2 were equally sensitive in differentiating the CAEP from noise. Conclusions: Hotelling's T2 appears to detect CAEPs from normal hearing infants at a rate equal to that of an experienced examiner. A clinical instrument that applies Hotelling's T2 on-line, so that the likelihood of response detection can be assessed objectively, should be of particular benefit to the novice or less experienced examiner.

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Cortical Auditory-Evoked Potentials in Response to Multitone Stimuli in Hearing-Impaired Adults

Journal of the American Academy of Audiology ◽

10.3766/jaaa.15068 ◽

2016 ◽

Vol 27 (05) ◽

pp. 406-415 ◽

Cited By ~ 2

Author(s):

Fabrice Bardy ◽

Jessica Sjahalam-King ◽

Bram Van Dun ◽

Harvey Dillon

Keyword(s):

Hearing Loss ◽

Evoked Potentials ◽

Hearing Impairment ◽

Auditory Evoked Potentials ◽

Hearing Impaired ◽

Detection Sensitivity ◽

Auditory Stimuli ◽

Significant Difference ◽

Objective Detection ◽

Cortical Auditory Evoked Potentials

Purpose: To determine if one-octave multitone (MT) stimuli increase the amplitude of cortical auditory-evoked potentials (CAEPs) in individuals with a hearing loss when compared to standard pure-tone (PT) stimuli and narrow-band noise (NBN). Research Design: CAEPs were obtained from 16 hearing-impaired adults in response to PT and MT auditory stimuli centered around 0.5, 1, 2, and 4 kHz and NBN centered around 1 and 2 kHz. Hearing impairment ranged from a mild to a moderate hearing loss in both ears. Auditory stimuli were monaurally delivered through insert earphones at 10 and 20 dB above threshold. The root mean square amplitude of the CAEP and the detectability of the responses using Hotelling’s T2 were calculated and analyzed. Results: CAEP amplitudes elicited with MT stimuli were on average 29% larger than PT stimuli for frequencies centered around 1, 2, and 4 kHz. No significant difference was found for responses to 0.5-kHz stimuli. Significantly higher objective detection scores were found for MT when compared to PT. For the 1- and 2-kHz stimuli, the CAEP amplitudes to NBN were not significantly different to those evoked by PT but a significant difference was found between MT stimuli and both NBN and PT. The mean detection sensitivity of MT for the four frequencies was 80% at 10 dB SL and 95% at 20 dB SL, and was comparable with detection sensitivities observed in normal-hearing participants. Conclusions: Using MT stimuli when testing CAEPs in adults with hearing impairment showed larger amplitudes and a higher objective detection sensitivity compared to using traditional PT stimuli for frequencies centered around 1, 2, and 4 kHz. These findings suggest that MT stimuli are a clinically useful tool to increase the efficiency of frequency-specific CAEP testing in adults with hearing impairment.

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More than a startle and a blink

PEDIATRICS ◽

10.1542/peds.60.6.934 ◽

1977 ◽

Vol 60 (6) ◽

pp. 934-935

Author(s):

Thomas A. Knauss

Keyword(s):

Evoked Potentials ◽

Pediatric Patient ◽

Auditory System ◽

Auditory Evoked Potentials ◽

Objective Assessment ◽

Acoustic Stimulus ◽

Facial Nerves ◽

Acoustic Nerve ◽

Cortical Auditory Evoked Potentials

Audiometry in the neonate most often depends on behavioral or autonomic reactions to an acoustic stimulus.1 A more objective assessment of hearing in the neonate can be obtained using the following techniques: (1) tympanometry, which depends on the mobility of the tympanic membrane2; (2) stapedial reflexes, which require the integrity of the acoustic nerve and its bilateral reflex brainstem connections through the facial nerves to the stapedius muscles and their attachment to the head of the stapes3; and (3) cortical auditory evoked potentials.4 A combination of techniques is often required to adequately test the auditory system of the pediatric patient.5

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Loudness Dependence of Auditory-evoked Potentials, a Marker of Central Serotonergic Activity, is Affected by Fasting and Selective Uptake of Food

Clinical EEG and Neuroscience ◽

10.1177/15500594211000925 ◽

2021 ◽

pp. 155005942110009

Author(s):

Christoph Bamberg ◽

Vera Flasbeck ◽

Georg Juckel ◽

Martin Brüne

Keyword(s):

Blood Glucose ◽

Evoked Potentials ◽

Repeated Measures ◽

Auditory Evoked Potentials ◽

Glucose Levels ◽

Fasting Condition ◽

Serotonergic Activity ◽

Blood Glucose Levels ◽

Significant Difference ◽

Loudness Dependence

Serotonin is an important neuromodulator involved in many physiological processes including mood and satiety. In the brain, serotonin is manufactured from tryptophan, as serotonin itself cannot cross the blood–brain barrier. Previous research has shown that blood-tryptophan levels increase upon ingestion of carbohydrates and decrease upon protein consumption. How this translates into serotonin availability is as yet under-researched. Therefore, we examined the effect of fasting versus consuming carbohydrates or protein on central serotonergic activity using a repeated-measures crossover design in a sample of 37 healthy men. The loudness dependence of auditory-evoked potentials (LDAEP) serves as a noninvasive method to study central serotonergic activity. Blood-glucose levels and mood changes were also monitored before and after the nutritional intervention. The intervention had a significant nutrition-specific effect on LDAEP and blood-glucose levels. A significant difference emerged between the fasting condition and satiety, with LDAEP being lower during satiety, irrespective of the type of food. Thus, this indicator of serotonergic activity increased after food consumption, which was further related to mood improvement. Moreover, the LDAEP differed between the 2 measurements only for the carbohydrate testing day, suggesting that LDAEP can be selectively modulated by the type of nutrition consumed. Our data further indicate a high intraindividual stability of LDAEP, as the electrophysiological signals were very similar in the fasting condition across the 2 testing days. Together, these findings demonstrate that the LDAEP can serve as a biological marker for central serotonergic activity, while at the same time being sensitive to nutritional changes.

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