Comparative Effects Of Tissular Urokinase And Urinary Urokinase In The Treatment Of 30 Patients With Pulmonary Embolism And Deep Venous Thrombosis
Two types of Urokinase are actually available for the clinical use : tissular urokinase (tUK), isolated from cell culture and urinary urokinase (uUK), partially purified from human urine. Their clinical and biological effects have to be compared.In this study 30 patients with acute pulmonary embolism and/or deep venous thrombosis were treated, using tUK or uUK, 4500 units/kg, during 12 hours.In the clinical field pulmonary angiographies, scintigrams, and phlebographies were obtained before and after the treatment. The biological study was first established on serial determination of fibrinogen, platelets, Quick Time, FDP using two methods and euglo- biiin lysis time. At the end of the treatment plasmatic samples of each patients were studied by immunoprecipitations followed by polyacrylamid gel electrophoresis, in the view of evaluation of the D dimer E complex. Two methods were used (LANE D.A. and al., 1977and WHITAKER A.N. and al, 1980).The results showed a quick similar improvement of the clinical situation. In return tUK appeared to be more effective on the biological point of view. Significant differences were found in : decrease of fibrinogen, increase of FDP and the presence of D dimer fragments. The better action of tUK, especially on the fibrin depositions, is so far unexplained.