Determination Of Thrombo Elastogram And Raby’S Transfer Test In Acute Myocardial Infarction

1981 ◽  
Author(s):  
J J Rodzynek ◽  
P L Schoenfeld ◽  
P Léautaud ◽  
T Martin ◽  
P Wettendorff ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Transfer Test ◽  
Myocardial Necrosis ◽  
Coronary Insufficiency ◽  
Mean Values ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Ischemia Group

Citrated whole blood thrombo elastogram (TEG) and its various parameters (r, k, am, IPT) and Raby’s transfer test (RTT) were performed in 52 healthy volunteers acting as normal controls (N), in 213 consecutive patients admitted in a general hospital for pathologies other than cardiac ischemia (group I), in 35 consecutive admissions for impending infarction without detectable myocardial necrosis (group II) and in 73 consecutive admissions for acute myocardial infarction, proved by EKG and specific enzyme determinations (group III).In conclusion: TEG is a poorly sensitive as well as poor specific indicator of unstable coronary insufficiency, with or without necrosis. RTT was found positive in 8.5% of unstable angina without demonstable myocardial necrosis, and in contrast in 94.5% of demonstrated acute myocardial infarction. Student’s test on mean values showed a highly significant difference (P<0.001). Further investigation is in progress to evaluate the usefulness of RTT for the early detection of myocardial necrosis.

scholarly journals ACUTE MYOCARDIAL INFARCTION

2006 ◽  
Vol 13 (02) ◽  
pp. 178-185
Author(s):  
ABDUL REHMAN ABID ◽  
M. Shahid Naveed ◽  
LIAQAT ALI ◽  
Siraj Munir Ahmed Tarin ◽  
M. TAHIR MOHYUDDIN ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Hospital Stay ◽  
Group Iv ◽  
Age Group ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Women with acute myocardial infarction have higher in-hospital mortalitythan men mainly due to greater age on presentation. Objective: To evaluate the age specific sex difference in inhospitalmortality of acute myocardial infarction. Design: Descriptive study. Place and duration: Coronary Care Unitand cardiology ward of Nishtar Hospital Multan from 15 of th September 2002 till 30th of April 2003. Material & Methods:Four hundred and fifty patients of acute myocardial infarction who fulfilled our inclusion criteria were studied while theywere admitted to the hospital. Patients were divided into four groups according to age and sex i.e. Group I (male <45years), Group II (male $45 years), Group III (female <45 years) and Group IV (female $45 years). In-hospital mortalitywas compared between different age groups by Chi-square test. Results: The total in-hospital mortality was76(16.9%).In Group III none of the patients expired. In Group I in-hospital mortality was 6(7.1%) patients followed byGroup II 50(18.3%) patients and Group IV 20(23.3%) patients p<0.019. In-hospital mortality was greater in Group IVthan in any other group. Group IV patients were more frequently diabetic and hypertensive than patients in any othergroup. Group IV patients presented late to the hospital. There was no significant difference in site of myocardialinfarction in different groups. Higher Killip class was observed in Group II and IV p<0.05. Streptokinase injection wasgiven less frequently in Group IV than in any other group p <0.012. Only 34(39.5%) patients in Group IV had nocomplication during hospital stay while more patients in other groups had uneventful hospital stay p<0.001.Conclusion: Female sex is associated with higher in-hospital mortality in older age group as compared to the malepatients of same age group.

scholarly journals ACUTE MYOCARDIAL INFARCTION

2006 ◽  
Vol 13 (03) ◽  
pp. 178-185
Author(s):  
ABDUL REHMAN ABID ◽  
M. Shahid Naveed ◽  
LIAQAT ALI ◽  
Siraj Munir Ahmed Tarin ◽  
M. TAHIR MOHYUDDIN ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hospital Mortality ◽  
Hospital Stay ◽  
Group Iv ◽  
Age Group ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Group Ii

Women with acute myocardial infarction have higher in-hospital mortalitythan men mainly due to greater age on presentation. Objective: To evaluate the age specific sex difference in inhospitalmortality of acute myocardial infarction. Design: Descriptive study. Place and duration: Coronary Care Unitand cardiology ward of Nishtar Hospital Multan from 15 of th September 2002 till 30th of April 2003. Material & Methods:Four hundred and fifty patients of acute myocardial infarction who fulfilled our inclusion criteria were studied while theywere admitted to the hospital. Patients were divided into four groups according to age and sex i.e. Group I (male <45years), Group II (male $45 years), Group III (female <45 years) and Group IV (female $45 years). In-hospital mortalitywas compared between different age groups by Chi-square test. Results: The total in-hospital mortality was76(16.9%).In Group III none of the patients expired. In Group I in-hospital mortality was 6(7.1%) patients followed byGroup II 50(18.3%) patients and Group IV 20(23.3%) patients p<0.019. In-hospital mortality was greater in Group IVthan in any other group. Group IV patients were more frequently diabetic and hypertensive than patients in any othergroup. Group IV patients presented late to the hospital. There was no significant difference in site of myocardialinfarction in different groups. Higher Killip class was observed in Group II and IV p<0.05. Streptokinase injection wasgiven less frequently in Group IV than in any other group p <0.012. Only 34(39.5%) patients in Group IV had nocomplication during hospital stay while more patients in other groups had uneventful hospital stay p<0.001.Conclusion: Female sex is associated with higher in-hospital mortality in older age group as compared to the malepatients of same age group.

scholarly journals Association between body mass index and 1-year outcome after acute myocardial infarction

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
D.W Kim
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Body Mass Index ◽  
Confidence Interval ◽  
Body Mass ◽  
Cardiac Death ◽  
Funding Source ◽  
Group Iii ◽  
End Point ◽  
Group I

Abstract Background Beneficial effects of overweight and obesity on mortality after acute myocardial infarction (AMI) have been described as “Body Mass Index (BMI) paradox”. However, the effects of BMI is still on debate. We analyzed the association between BMI and 1-year major cardiocerebrovascular events (MACCE) after AMI. Methods and findings Among 13,104 AMI patients registered in an Institute of Health in Korea between November 2011 and December 2015, 10,568 patients who eligible for this study were classified into 3 groups according to BMI (Group I; &lt;22 kg/m2, 22 ≤ Group II &lt;26 kg/m2, Group III; ≥26 kg/m2). The primary end point was a composite of cardiac death (CD), myocardial infarction (MI), target vessel revascularization (TVR), and cerebrovascular events at 1 year. Over the median follow-up of 12 months, the composite of primary end point occurred more frequently in the Group I patients than in the Group III patients (primary endpoint: adjusted hazard ratio [aHR], 1.290; 95% confidence interval [CI] 1.024 to 1.625, p=0.031). Especially, cardiac death in MACCE components played a major role in this effect (aHR, 1.548; 95% confidence interval [CI] 1.128 to 2.124, p=0.007). Conclusions Higher BMI appeared to be good prognostic factor on 1-year MACCE after AMI. This result suggests that higher BMI or obesity might confer a protective advantage over the life-quality after AMI. Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): Research of Korea Centers for Disease Control and Prevention and the Korea Health Technology R&D Project, Ministry of Health & Welfare (HI13C1527), Republic of Korea.

scholarly journals Detection and Characterization of Prevotella Intermedia and Its In Vitro Susceptibility to Selected Antimicrobial Agents in Chronic Periodontitis and Acute Myocardial Infarction

2019 ◽  
Vol 3 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Deepa Anumala ◽  
Mohan Kumar Pasupuleti ◽  
Ravindra Reddy Nagireddy
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Chronic Periodontitis ◽  
Antimicrobial Agents ◽  
Prevotella Intermedia ◽  
Causative Role ◽  
In Vitro Susceptibility ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Background: Periodontal disease has been reported to play a causative role in acute myocardial infarction (AMI), which may add to the various risk factors associated with coronary heart disease. The objective of the present study was to investigate the presence of Prevotella intermedia – an established periodontal pathogen – in subgingival plaque samples of chronic periodontitis and AMI patients in order to identify a possible association, and to evaluate the susceptibility of Prevotella intermedia to nine antimicrobial agents. Methods: After undergoing screening for eligibility, a total of 50 subjects were included in the present study. Twenty patients were diagnosed with AMI and generalized chronic periodontitis (Group I), 20 patients were diagnosed with only AMI (Group II), and 10 subjects were healthy controls (Group III). The isolated Prevotella intermedia strains were tested for susceptibility to bacitracin, chloramphenicol, penicillin G, polymyxin, gentamycin, neomycin, tetracycline, cefotaxime, and cefoxitin using an antibiotic zonescale to determine minimum inhibitory concentrations (MICs). Results: Periodontal pathogens were identified by phenotypic and enzymatic methods. The mean bacterial load of Prevotella intermedia species was higher in Group I compared to Group II and Group III. It was also found that pencillin G, gentamycin, neomycin, tetracycline, cefotaxime, and cefoxitin inhibited 90% of Prevotella intermedia, whereas bacitracin, chloramphenicol, and polymyxin inhibited 80% of Prevotella intermedia. Thus, only 10% of Prevotella intermedia were resistant to these antibiotics. Conclusion: The present study confirms that Prevotella intermedia is associated with chronic periodontitis and AMI.

Clinical evaluation of immunochemical assay of lactate dehydrogenase isoenzyme 1 in early detection of acute myocardial infarction.

1982 ◽  
Vol 28 (10) ◽  
pp. 2152-2154 ◽  
Author(s):  
T Y Wang ◽  
J H Godfrey ◽  
L G Graham ◽  
M N Haddad ◽  
T C Hamilton
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lactate Dehydrogenase ◽  
Myocardial Ischemia ◽  
Clinical Presentation ◽  
Myocardial Infarct ◽  
Acute Myocardial Infarct ◽  
Group Iii ◽  
Dehydrogenase Isoenzyme ◽  
Group I

Abstract We immunochemically measured lactate dehydrogenase isoenzyme 1 (LD-1), calculated LD-1/LD ratios (% LD-1) for 122 specimens from 60 patients, and compared the results with those for the conventional cardiac profile and other findings such as clinical presentation and electrocardiogram. Results for LD-1 and % LD-1 could be classified into three groups: group I, with LD-1 less than 64 U/L; group II, with LD-1 greater than 64 U/L and % LD-1 between 17 and 37%; and group III, with LD-1 greater than 64 U/L and 5 LD-1 greater than 38%. These three groups correlated closely and consistently with three patients of cardiac profile, i.e., those of no acute myocardial infarct, myocardial ischemia, and acute myocardial infarct, respectively.

Phaeochromocytoma-Induced Myocardial Necrosis

1991 ◽  
Vol 36 (6) ◽  
pp. 184-184 ◽  
Author(s):  
S.J. Bourke ◽  
G. Wilkes ◽  
D.L.J. Maloney ◽  
G. Terry
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Pulmonary Oedema ◽  
Coronary Arteries ◽  
Myocardial Necrosis ◽  
Coronary Insufficiency ◽  
Normal Coronary Arteries

A case is described in which acute myocardial infarction and pulmonary oedema occurred in a patient with normal coronary arteries as the result of metabolically induced coronary insufficiency in a phaeochromocytomic crisis.

PROTECTIVE EFFECT OF CARNITINE (ST-261, SIGMA-TAU) IN ACUTE MYOCARDIAL INFARCTION IN DOGS

1987 ◽  
Author(s):  
K Kordenat ◽  
J Leasure
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Protective Effect ◽  
Myocardial Necrosis ◽  
Control Group ◽  
Computer Technique ◽  
T Wave ◽  
Group I ◽  
The Mean ◽  
Group Ii

Limitation of infarct size (IS), using ST-261, was evaluated in a group (I) of eight dogs, during acute MI. Another group (II) served as the control group. The protocol for both groups was the same except that each dog in the treated group was ST-261 as a single bolus (25 mg/kg, in 20ml normal saline), before inducing an occluding thrombus in the mid-LAD, using a closed-chest model, under x-ray visualization. Percentages of total (gms) myocardium at jeopardy (TMJW) and myocardial necrosis (TMNW), delineated by fluoroscein and TTC dyes, respectively, were calculated and compared to the total ventricular myocardial weight (TVMU), by computer technique for both groups at 3 Hrs post-occlusion of the LAD. Mean serum total CPK (CPK-t) and isozymes (mb-band) were measured before and up to 3 Hrs post-occlusion, as were various hemodynamic and mean precordial (21 lead) ST-segment and T-wave amplitudes. There was 14% less TMJU (p<0.05) and 41% less TMNW (p<0.01) in Group I compared to Group II. The mean % of CPK-mb/CPK-t decreased in I and increased in II over the 3 Hrs of observation. Mean HR decreased (p<0.01) in I compared to II at 3 Hrs postocclusion. The sum of the mean T-wave amplitudes from the precordial electrode sites was less in I at 3 Hrs. It is felt that ST-261 had a protective effect on the myocardium during acute myocardial infarction.

Circulating Platelet Aggregates In Thrombotic Pathologies

1981 ◽  
Author(s):  
J J Rodzynek ◽  
P L Schoenfeld ◽  
T Martin ◽  
P Léautaud ◽  
P Wettendorff ◽  
...  
Keyword(s):  
Myocardial Necrosis ◽  
Group Iv ◽  
Group V ◽  
Coronary Insufficiency ◽  
Group Iii ◽  
Group I ◽  
Acute Coronary Insufficiency ◽  
Circulating Platelet Aggregates ◽  
Platelet Aggregates ◽  
Normal Controls

The dosage of circulating platelet aggregates following Wu and Hoak (CPA) was performed in 52 healthy volunteers acting as normal controls (N), in 205 consecutive patients admitted in a general hospital for pathologies other than thrombotic or cardiac ischaemia (group I), in 59 consecutive admissions for deep venous thrombosis (group II), in 45 consecutive admissions for pulmonary thromboembolism (group III), in 35 consecutive admissions for acute coronary insufficiency (group IV) and in 73 consecutive admissions for acute myocardial infarction demonstrated by electrocardiogram and specific enzymes (group V). The percentage of positive tests (CPA 0.80) in those various groups appeared as follows: In conclusion: The positivity of CPA is not a specific indicator of a thrombotic disease neither of acute coronary insufficiency (36.5% false positive tests). CPA is not sensitive for the diagnosis of thrombotic conditions.In the setting of ischaemic heart disease, CPA positivity appears with higher frequency when myocardial necrosis is demonstrated, However the two groups don’t differ significantly on a statistical basis (P non significant).

scholarly journals Coronary flow and hemorrhagic complications after alteplase and streptokinase administration in patients with acute myocardial infarction

2009 ◽  
Vol 66 (3) ◽  
pp. 218-222
Author(s):  
Tomislav Kostic ◽  
Zoran Perisic ◽  
Dragan Milic ◽  
Svetlana Apostolovic ◽  
Sonja Salinger-Martinovic ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Major Bleeding ◽  
Coronary Flow ◽  
Coronary Intervention ◽  
Bleeding Complications ◽  
Group I ◽  
Number Of Patients ◽  
Significant Difference ◽  
St Elevation

Background/Aim. Up-to-date treatment of acute myocardial infarction (AIM) has been based on as early as possible establishment of circulation in ischemic myocardium whether by the use of fibrinolythic therapy and/or urgent coronary intervention which significantly changes the destiny of patients with AMI, but also increases the risk of bleeding. The aim of this study was to compare coronary flow and bleeding complications in patients with acute myocardial infarction with ST-elevation (STEMI) after administration of alteplase or streptokinase. Methods. The study included 254 patients with STEMI. The group I (n = 174) received streptokinase, and the group II (n = 80) received alteplase. We followed frequency of complications such as bleeding and hypotension in the investigated groups of patients, based on the TIMI classification of bleeding, as well as the transience of infarction artery in accordance with TIMI flow. Results. The patients with myocardial infarction after administration of alteplase had statistically significantly higher coronary flow (TIMI- 3), 72.5% as compared to the patients who received streptokinase, 39.2%. Hypotension as complication of fibrynolythic therapy administration occurred in a significantly higher percentage in the group of patients who received streptokinase. There was no statistically significant difference in the appearance of major bleeding in the groups of patients who received streptokinasis and alteplase (6.9% and 7.5%, respectively). Also, there was no difference in the appearance of minor and minimal bleeding among the investigated groups of patients. Conclusion. It was shown that alteplase in a higher number of patients provided TIMI-3 coronary flow as compared to streptokinese. In comparison with streptokinase, a combination of alteplase, enoxaparin and double antiplatelet therapy enabled earlier achievement of coronary flow through previously blocked coronary artery that was more complete (higher frequency of TIMI-3 flow). There were no statistically significant difference in frequency of bleeding, first of all major bleeding, between the groups treated by alteplase and streptokinase.

scholarly journals P749 Echocardiographic risk factors of functional ischemic mitral regurgitation in patients with first acute myocardial infarction

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
J Kochanowski ◽  
R Piatkowski ◽  
P Scislo ◽  
M Budnik ◽  
M Marchel ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Mitral Regurgitation ◽  
Left Ventricular ◽  
Group Iv ◽  
Ischemic Mitral Regurgitation ◽  
Mean Values ◽  
St Segment Elevation ◽  
Group Iii ◽  
Group I ◽  
Group Ii

Abstract Purpose The aim of this study was to assess the correlation between the size of acute functional ischemic mitral regurgitation (FIMR) and selected left ventricle echocardiography measurements in patients (pts) with first ST-segment elevation myocardial infarction (STEMI) treated with effective primary angioplasty (PCI). Methods We analyzed 1578 consecutive hospitalized pts with STEMI (M-914; 66,4 ± 10,2 years) treated with PCI. The echocardiographic examination was performed at up to 3 days after admission. We assessed the frequency and size of FIMR, left ventricular end diastolic diameter (LVEDd), ejection fraction (EF), wall motion score index (WMSI) and systolic sphericity index (Sls). Effective regurgitation orifice area (EROA) was used for quantitative FIMR assessment (mild: &lt;10 mm², moderate: ≥10 and &lt; 20 mm², severe: ≥ 20mm²). The study population was divided into four groups depending on the size of FIMR. Correlation coefficient was used to determine correlations between data sets. Results We observed mild FIMR in 550 pts (34,9%) - group I, moderate in 356 pts (22,5%) - group II, severe in 57 pts (3,6%) - group III, no FIMR in 615 pts (39%) – group IV. Mean values of selected echocardiographic parameters in each analyzed group are shown in table 1. The positive good correlations between SIs and size of FIMR were found (r = 0,68) as well as weak correlations between LVEDd, WMSI and FIMR (ro = 0,25, ro = 0,34, respectively). The negative weak correlation between EF and size of IMR was present (ro = - 0,34). Conclusions 1. FIMR is a common complication in pts with STEMI treated with PCI. 2. We found a statistically significant correlation between SIs and FIMR severity. Table 1 Group I Group II Group III Group IV p LVEDd (cm) 5,22 ± 0,64 5,42 ± 0,56 5,72 ± 0,64 4,98 ± 0,58 NS EF (%) 48 ± 6 42 ± 8 35 ± 8 51 ± 8 NS WMSI 1,34 ± 0,28 1,42 ± 0,24 1,68 ± 0,32 1,32 ± 0,22 NS SIs 0,22 ± 0,1 0,32 ± 0,1 0,68 ± 0,1 0,18 ± 0,1 0,01 NS - non-significant

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