The Relationship of Blood Viscosity to Coronary Artery Disease

1979 ◽  
Author(s):  
G.D.O. Lowe ◽  
M.M. Drummond ◽  
A.R. Lorimer ◽  
I. Hutton ◽  
C.D. Forbes ◽  
...  

Increases in blood viscosity and its determinants (haematocrit and plasma fibrinogen) have been described in groups of subjects with clinical manifestations of arterial disease (myocardial infarction, angina, claudication). Viscosity factors may also be risk associations in prospective studies. We have studied the relationship of blood viscosity (shear rate 100s-0), haematocrit and fibrinogen to the extent of coronary artery occlusion in 50 males, aged 30-55, prior to coronary arteriography for chest pain. 26 subjects had significant occlusion (>50 per cent stenosis) of 2 or 3 major coronary arteries: 24 had single vessel disease or normal coronary arteries. 25 healthy controls were also studied. There were no significant differences in age or smoking habits between the three groups: use of beta-adrenergic blockers and plasma lipid levels were comparable in the two arteriography groups. Patients with extensive coronary artery disease had increased levels of viscosity and haematocrit (p<0.005), fibrinogen (p<0. 02) and viscosity corrected for haematocrit (p<0. 05), compared to angiographic or asymptomatic controls.

PEDIATRICS ◽  
1962 ◽  
Vol 29 (4) ◽  
pp. 566-578
Author(s):  
George Bialkin ◽  
Saul Zucker ◽  
Burton S. Sklarin ◽  
Kurt Hirschhorn ◽  
Murray Davidson

A family consisting of a mother and father, heterozygous for idiopathic hyperlipemia, and their four offspring, one heterozygous and three homozygous for the disease, are described. In addition, a fifth child who is heterozygous, born of same mother but by another incompletely studied father, is presented. The genetics of the disease in this family, and also in the general population, with emphasis on diagnosis and prognosis in heterozygotes is discussed. The interrelationship of various lipid components in serum and their metabolism are briefly reviewed. The possible defective mechanisms in hyperlipemia, the techniques for deciding on the specific defect, and their application to the members of this family are reviewed. The effect of heparin, nicotinic acid, and fat-free diets in the homozygous members of the family are evaluated and their therapeutic applications are discussed. The symptomatology, possible pathologic physiology, relationship to lipid levels in serum and occurrence of abdominal crises in some of the homozygous members of this family are pointed out. The relationship of cholesterol and triglyceride levels in serum to, and the significance of, idiopathic hyperlipemia in the genesis of, atherosclerosis and coronary artery disease is elucidated.


2018 ◽  
Vol 10 (2) ◽  
pp. 70-75 ◽  
Author(s):  
Turgut Karabağ ◽  
Emіne Altuntaş ◽  
Belma Kalaycı ◽  
Bahar Şahіn ◽  
Mustafa Umut Somuncu ◽  
...  

Cardiology ◽  
1979 ◽  
Vol 64 (1) ◽  
pp. 48-57 ◽  
Author(s):  
Fulv&iacute;o Pileggi ◽  
Paulo Roberto Camargo ◽  
Egas Armelin ◽  
Giovanni Bellotti ◽  
Prot&aacute;sio da Luz ◽  
...  

2021 ◽  
Author(s):  
Xinyi Zhang ◽  
Sicong Li ◽  
Yuxuan Zhao ◽  
Ningjia Tang ◽  
Tong Jia ◽  
...  

Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searched the electronic database for articles on the relationship of PEAR1 SNPs and ischemic events in patients with coronary artery disease (CAD) up to October 2020. Results: A total of 9914 patients with CAD from six studies focusing on 12 SNPs of PEAR1 were included in this study. The A allele of rs12041331 were associated with ischemic events (odds ratio: 1.40; 95% CI: 1.04–1.88; p = 0.03). The AA homozygotes of rs2768759 was related to a higher risk of ischemic events than carriers of the C allele (odds ratio: 2.08; 95% CI: 1.09–3.97; p = 0.03). Conclusion: PEAR1 rs12041331 and rs2768759 are significantly associated with ischemic events in patients with CAD.


2020 ◽  
Vol 41 (34) ◽  
pp. 3255-3268 ◽  
Author(s):  
L Christian Napp ◽  
Victoria L Cammann ◽  
Milosz Jaguszewski ◽  
Konrad A Szawan ◽  
Manfred Wischnewsky ◽  
...  

Abstract Aims Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. Methods and results Coronary anatomy and CAD were studied in patients diagnosed with TTS. Inclusion criteria were compliance with the International Takotsubo Diagnostic Criteria for TTS, and availability of original coronary angiographies with ventriculography performed during the acute phase. Exclusion criteria were missing views, poor quality of angiography loops, and angiography without ventriculography. A total of 1016 TTS patients were studied. Of those, 23.0% had obstructive CAD, 41.2% had non-obstructive CAD, and 35.7% had angiographically normal coronary arteries. A total of 47 patients (4.6%) underwent percutaneous coronary intervention, and 3 patients had acute and 8 had chronic coronary artery occlusion concomitant with TTS, respectively. The presence of CAD was associated with increased incidence of shock, ventilation, and death from any cause. After adjusting for confounders, the presence of obstructive CAD was associated with mortality at 30 days. Takotsubo syndrome patients with obstructive CAD were at comparable risk for shock and death and nearly at twice the risk for ventilation compared to an age- and sex-matched ACS cohort. Conclusions Coronary artery disease frequently coexists in TTS patients, presents with the whole spectrum of coronary pathology including acute coronary occlusion, and is associated with adverse outcome. Trial registration ClinicalTrials.gov number: NCT01947621.


Antioxidants ◽  
2019 ◽  
Vol 8 (10) ◽  
pp. 484 ◽  
Author(s):  
Victor J. van den Berg ◽  
Maxime M. Vroegindewey ◽  
Isabella Kardys ◽  
Eric Boersma ◽  
Dorian Haskard ◽  
...  

Antibodies to oxidized LDL (oxLDL) may be associated with improved outcomes in cardiovascular disease. However, analysis is restricted by heterogenous study design and endpoints. Our objective was to conduct a comprehensive systematic review assessing anti-oxLDL antibodies in relation to coronary artery disease (CAD). Through a systematic literature search, we identified all studies assessing the relationship of either, IgG or IgM ox-LDL/ copper-oxLDL/ malondialdehyde-LDL, with coronary atherosclerosis or cardiovascular events in populations with, and without, established CAD. Systematic review best practices were adhered to and study quality was assessed. An initial electronic database search identified 2059 records, which was subsequently followed by abstract and full-text review. Finally, we included 18 studies with over 1811 patients with CAD. The studies varied according to populations studied, conventional cardiovascular risk factors and interventional modalities used to assess CAD. IgM anti-oxLDL antibodies were found to indicate protection from more severe CAD and possibly cardiovascular events, whilst the relationship with IgG is more complex and difficult to elucidate, with studies reporting divergent results. In this systematic review, there is evidence that suggests a relationship between anti-oxLDL antibodies and CAD, especially for the IgM subclass. However, further studies, with well-characterized prospective cohorts, will be important to clarify these associations.


2000 ◽  
Vol 4 (3) ◽  
pp. 253-258 ◽  
Author(s):  
H. B. Bosworth ◽  
D. C. Steffens ◽  
M. N. Kuchibhatla ◽  
W. J. Jiang ◽  
R. M. Arias ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document