Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid

Synlett ◽  
2019 ◽  
Vol 30 (17) ◽  
pp. 2004-2009 ◽  
Author(s):  
Vindya K. Gopinatha ◽  
Hassan A. Swarup ◽  
Sathees C. Raghavan ◽  
Kempegowda Mantelingu ◽  
Kanchugarakoppal S. Rangappa
Keyword(s):  
Oxalic Acid ◽  
Spiro Compounds ◽  
Regioselective Synthesis ◽  
Amino Group ◽  
Subsequent Reaction ◽  
Unsaturated Ketones ◽  
Novel Approach ◽  
Spiro Derivatives ◽  
One Step ◽  
Acid Catalyzed

A vital approach for the synthesis of a range of novel thioxotriaza-spiro derivatives is described. These new heterocyclic systems are obtained via oxalic acid catalyzed reaction of α,β-unsaturated ketones in the presence of 5,6-diamino-2-mercaptopyrimidine-4-ols; thus, spiro rings are constructed in one step. Notably, this transformation involves condensation of an amino group followed by enamine reaction with alkenes and subsequent reaction promoted by oxalic acid to afford spiro compounds with excellent regioselectivity.

One-step functionalization of carbon fiber using in situ generated aromatic diazonium salts to enhance adhesion with PPBES resins

RSC Advances ◽  
2016 ◽  
Vol 6 (74) ◽  
pp. 70704-70714 ◽  
Author(s):  
Nan Li ◽  
Zuoqiang Wu ◽  
Lei Huo ◽  
Lishuai Zong ◽  
Yujie Guo ◽  
...  
Keyword(s):  
Carbon Fiber ◽  
Carbon Fibers ◽  
Sulfhydryl Group ◽  
Hydroxyl Group ◽  
Diazonium Salts ◽  
Amino Group ◽  
Novel Approach ◽  
One Step

In the present study, we developed a novel approach to introduce amino group (–NH2), hydroxyl group (–OH) and sulfhydryl group (–SH) onto carbon fibers (CFs) using aromatic diazonium salts.

Mild Oxalic-Acid-Catalyzed Hydrolysis as a Novel Approach to Prepare Cellulose Nanocrystals

ChemNanoMat ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Wenyang Xu ◽  
Henrik Grénman ◽  
Jun Liu ◽  
Dennis Kronlund ◽  
Bin Li ◽  
...  
Keyword(s):  
Oxalic Acid ◽  
Cellulose Nanocrystals ◽  
Novel Approach ◽  
Acid Catalyzed

ChemInform Abstract: Broensted Acid Catalyzed C-C Bond Forming Reaction for One-Step Synthesis of Oxazinanones.

ChemInform ◽  
2011 ◽  
Vol 42 (47) ◽  
pp. no-no
Author(s):  
Nazim Uddin ◽  
Joseph S. Ulicki ◽  
F. Holger Foersterling ◽  
M. Mahmun Hossain
Keyword(s):  
Bond Forming ◽  
One Step ◽  
Acid Catalyzed

Synergistic effect of co-reactant promotes one-step oxidation of cyclohexane into adipic acid catalyzed by manganese porphyrins

2015 ◽  
Vol 93 (7) ◽  
pp. 696-701 ◽  
Author(s):  
Hui Li ◽  
Yuanbin She ◽  
Haiyan Fu ◽  
Meijuan Cao ◽  
Jing Wang ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Co Oxidation ◽  
Adipic Acid ◽  
Molar Ratio ◽  
Reaction Conditions ◽  
Catalyst Structure ◽  
Manganese Porphyrins ◽  
Co Oxidation Reaction ◽  
One Step ◽  
Acid Catalyzed

The synergistic effect of cyclohexane and cyclohexanone promoted synthesis of adipic acid catalyzed by [MnIIIT(p-Cl)PP]Cl with cyclohexane and cyclohexanone as co-reactants. The results showed that the conversions of cyclohexane and cyclohexanone were significantly enhanced because of the cyclohexanone synergistic effect, and the higher selectivity to adipic acid was obtained with dioxygen as an oxidant. The studies indicated that the co-oxidation of cyclohexane and cyclohexanone was influenced by the initial molar ratio of cyclohexanone and cyclohexane, catalyst structure, catalyst concentrations, and reaction conditions. The preliminary mechanism of the co-oxidation reaction of cyclohexane and cyclohexanone using [MnIIIT(p-Cl)PP]Cl as the catalyst was proposed.

One-pot Synthesis of α,β-Unsaturated Ketones through Sequential Alkyne Dimerization/Hydration Reactions using Hoveyda-Grubbs Catalyst

2021 ◽  
Author(s):  
Bengi Öztürk ◽  
Begüm Sarıaslan ◽  
Mina Aşkun ◽  
Zeynep Tunalı ◽  
Solmaz Karabulut
Keyword(s):  
Regioselective Synthesis ◽  
Grubbs Catalyst ◽  
One Pot ◽  
Unsaturated Ketones ◽  
One Pot Synthesis

Herein we report a sequential one-pot alkyne dimerization/hydration protocol for the regioselective synthesis of α,β-unsaturated ketones in quantitive yields. The alkyne dimerization reactions of terminal arylacetylenes proceeded with high regioselectivity...

Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

2015 ◽  
Vol 113 (06) ◽  
pp. 1312-1322 ◽  
Author(s):  
Sofia Nordling ◽  
Jaan Hong ◽  
Karin Fromell ◽  
Fredrik Edin ◽  
Johan Brännström ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Thrombus Formation ◽  
Innate Immune ◽  
Human Endothelial Cells ◽  
Coagulation Activation ◽  
Ischaemia Reperfusion Injury ◽  
Novel Approach ◽  
One Step ◽  
Chamber Model

SummaryIschaemia-reperfusion injury (IRI) poses a major challenge in many thrombotic conditions and in whole organ transplantation. Activation of the endothelial cells and shedding of the protective vascular glycocalyx during IRI increase the risk of innate immune activation, cell infiltration and severe thrombus formation, promoting damage to the tissue. Here, we present a novel one-step strategy to protect the vasculature by immobilisation of a unique multi-arm heparin conjugate to the endothelium. Applying a new in vitro blood endothelial cell chamber model, the heparin conjugate was found to bind not only to primary human endothelial cells but also directly to the collagen to which the cells adhered. Incubation of hypoxic endothelial cells with freshly drawn human blood in the blood chambers elicited coagulation activation reflected by thrombin anti-thrombin formation and binding of platelets and neutrophils. Immobilisation of the heparin conjugate to the hypoxic endothelial cells created a protective coating, leading to a significant reduction of the recruitment of blood cells and coagulation activation compared to untreated hypoxic endothelial cells. This novel approach of immobilising multi-arm heparin conjugates on the endothelial cells and collagen of the basement membrane ensures to protect the endothelium against IRI in thrombotic disorders and in transplantation.

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