scholarly journals Intracardiac Metastasis from a Large Cell Neuroendocrine Lung Carcinoma

2019 ◽  
Vol 08 (01) ◽  
pp. e41-e43
Author(s):  
Christopher Gaisendrees ◽  
Kaveh Eghbalzadeh ◽  
Navid Mader ◽  
Thorsten C. W. Wahlers
Keyword(s):  
Lung Carcinoma ◽  
Malignant Tumors ◽  
Close Contact ◽  
Large Cell ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Cardiac Metastases ◽  
The Right ◽  
Cava Vein ◽  
Inferior Cava Vein

AbstractPrimary malignant tumors of the heart are rare; the biggest group is sarcomas. Cardiac metastases make up the biggest group of secondary cardiac tumors. We present a rare case of cardiac metastasis (3.1 × 3.2 × 2.8 cm) localized in the right atrium, originating from a large cell neuroendocrine lung carcinoma, with close contact to the tricuspid valve and inferior cava vein.

scholarly journals Cardiac Angiosarcoma

2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Monique Esteves Cardoso ◽  
Leonardo Secchin Canale ◽  
Rosana Grandelle Ramos ◽  
Edson da Silva Salvador Junior ◽  
Stephan Lachtermacher
Keyword(s):  
Adjuvant Therapy ◽  
Right Atrium ◽  
Malignant Tumors ◽  
Tumor Resection ◽  
Cardiac Tumors ◽  
Primary Tumors ◽  
Cardiac Angiosarcoma ◽  
Cardiac Metastases ◽  
The Right ◽  
Primary Cardiac Tumors

Despite cardiac metastases are found in about 20% of cancer deaths, the presence of primary cardiac tumors is rare. Most primary tumors are benign, and malignant tumors comprise about 15%. We report a 21-year-old man with fever, dyspnea, and hemoptysis that was diagnosed with angiosarcoma of the right atrium and pulmonary metastasis. Patient was submitted to surgical tumor resection without adjuvant therapy and died four months after diagnosis.

scholarly journals Biatrial Cardiac Metastases in a Patient with Uterine Cervix Malignant Melanoma

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Caglayan Geredeli ◽  
Melih Cem Boruban ◽  
Necdet Poyraz ◽  
Mehmet Artac ◽  
Alpay Aribas ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Uterine Cervix ◽  
Tissue Characterization ◽  
Primary Melanoma ◽  
Diagnostic Techniques ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Malignant Melanomas ◽  
Cardiac Metastases

Primary malignant melanomas of uterine cervix are quite rarely seen neoplasms, and long-life prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis. As with other melanomas, cervix malignant melanomas may also cause cardiac metastases. Cardiac metastases are among rarely seen but more commonly encountered cases, compared to primary cardiac tumors. Here, we present a case of biatrial cardiac metastases in a 73-year-old patient with uterine cervix malignant melanomas. The patient underwent echocardiography, cardiac magnetic resonance imaging, and computed tomography. Our report shows the importance of advanced diagnostic techniques, such as cardiac magnetic resonance, not only for the detection of cardiac masses, but for a better anatomic definition and tissue characterization. Although the cases of malignant melanomas leading to multiple cardiac metastasis were reported in literature, the metastatic concurrence of malignant melanomas in both right and left atriums is quite rarely encountered as metastatic malignant melanomas. Also, another intriguing point in our case is that the primary lesion of our case was stemmed from uterine cervix, but not skin.

scholarly journals Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy

2016 ◽  
Vol 9 (2) ◽  
pp. 440-446 ◽  
Author(s):  
Kozo Nagai ◽  
Yukari Suyama ◽  
Daisuke Koga ◽  
Masanori Nishi ◽  
Chiaki Iida ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Anaplastic Lymphoma Kinase ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Cardiac Metastasis ◽  
Anterior Tibial Artery ◽  
Anaplastic Lymphoma ◽  
Large Cell Lymphoma ◽  
The Right ◽  
Heart Metastasis

We described an 11-year-old boy suffering from pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with heart metastasis at diagnosis and arterial tumor embolisms during chemotherapy. Both the heart metastasis and pericardial effusion showed improvement with prednisolone, but numbness and pallor sequentially developed in his lower extremities during the first course of chemotherapy. Contrast-enhanced imaging revealed occlusion of the right anterior tibial artery and left popliteal artery. These symptoms were spontaneously remitted due to the compensation of other arteries. Arterial tumor embolism is a rare but possible complication when a lymphoma shows intracardiac infiltration.

Cardiac Tumors: Surgical Experience in Thirty-Nine Cases

1996 ◽  
Vol 4 (1) ◽  
pp. 14-17
Author(s):  
Rajendar Krishan Suri ◽  
Raghuvir Singh Kanwar ◽  
Harjinder Singh ◽  
Rajinder Singh Dhaliwal ◽  
Sandeep Singh Rana ◽  
...  
Keyword(s):  
Malignant Fibrous Histiocytoma ◽  
Malignant Tumors ◽  
Fibrous Histiocytoma ◽  
Postoperative Radiotherapy ◽  
Right Atrial ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Malignant Group ◽  
The Right

Over a period of 18 years, 39 cases of cardiac tumors were operated upon in the Department of Cardiothoracic Surgery at the Postgraduate Institute of Medical Education and Research, Chandigarh. These included 34 (87%) patients with benign tumors and 5 (13%) patients with primary malignant tumors. All the benign tumors were myxomas, of which 31 (91.2%) were in the left atrium and 3 (8.8%) in right atrium. Primary malignant tumors comprised 2 rhabdomyosarcomas, 1 angiosarcoma, 1 lymphoma and 1 case of pleomorphic malignant fibrous histiocytoma. The diagnosis was established by echocardiography, angiocardiography and computed tomography. In one case the diagnosis was made at autopsy. All myxomas, except tricuspid valve myxoma, were removed completely through right atrial or biatrial approach with the use of cardiopulmonary bypass. Four cases of primary malignant tumors were non-resectable. Near total resection of a malignant fibrous histiocytoma arising from the right middle pulmonary vein and left atrial junction was achieved. There were 2 operative deaths (5.1 %). The follow-up ranged from 3 months to 10 years with a mean of 5.7 years. There was 1 recurrence (2.9%) in the benign group. In the malignant group, 3 cases (60%) died within 5 to 8 months of surgery due to further local and metastatic spread of the tumor. The case of malignant fibrous histiocytoma was treated with postoperative radiotherapy to the right mediastinum and is doing well at follow-up 3 months after surgery.

Surgical Treatment of Primary Cardiac Tumors

1997 ◽  
Vol 5 (2) ◽  
pp. 101-103 ◽  
Author(s):  
Gu Chun Jiu ◽  
Bao Wei Ke ◽  
Guo Bin Xun ◽  
Yuan Hong ◽  
Xiu Zhong Yi
Keyword(s):  
Surgical Treatment ◽  
Malignant Tumors ◽  
Right Atrial ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Long Term Result ◽  
The Right ◽  
Medical University ◽  
Primary Cardiac Tumors

During a 16-year period from 1980 to 1996, 101 patients with primary cardiac tumors underwent surgery at the 1st Affiliated Hospital of China Medical University, which represented 2.44% of 4142 open-heart surgical cases during this period. Most tumors were benign; 94 were myxomas, 2 were fibromas, and 1 was a hemangioma. Three myxomas were in the right atrium and 91 were in the left atrium. The 4 malignant tumors comprised 2 mesothelioma, 1 histiocytoma, and 1 right atrial malignant myxoma. All benign tumors were completely excised with 4.95% mortality. Only 1 malignant tumor was completely excised. In our experience, the long-term result of surgical treatment of benign cardiac tumors is excellent, whereas the prognosis for patients with malignant cardiac tumors is very poor. The incidence of malignant tumors was lower than in other studies.

scholarly journals SURGICAL CORRECTION OF CARDIAC METASTASES FROM CERVICAL CANCER

2018 ◽  
Vol 17 (3) ◽  
pp. 109-114
Author(s):  
V. M. Shipulin ◽  
S. L. Andreev ◽  
A. S. Pryakhin ◽  
V. V. Shipulin ◽  
L. N. Bondar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pulmonary Hypertension ◽  
Surgical Treatment ◽  
Right Ventricular ◽  
Cancer Metastasis ◽  
External Beam Radiotherapy ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Right Ventricular Mass ◽  
Cardiac Metastases

Metastases to the heart are extremely rare, and the reported incidence of cardiac metastasis at autopsy ranges from 1.5 to 21.8  %. In cancer patients, cardiac metastases are usually difficult to  diagnose unless the patients do not complain of any related  symptoms. Common tumors with cardiac metastasis potential are  usually carcinomas of the lung, breast, and malignant lymphoma.  The prognosis of a metastatic heart tumor is unfavorable. The  average life expectancy for patients with this diagnosis is less than  six months. In addition, surgical treatment of primary cardiac tumors or metastatic cardiac tumors is associated with high risk of  perioperative lethality. Case report. We present a rare case of  cervical cancer metastasis to the heart in a 33-year-old woman.  Cytological examination revealed no evidence of disease recurrence  14 months after the completion of external beam radiotherapy.  Echocardiography showed a mass in the outflow tract of the right ventricle and findings of severe pulmonary hypertension.  omputed tomography and magnetic resonance imaging revealed a  large right ventricular thrombus. The patient underwent surgery with  artificial circulation. Pathohistological and immunohistochemical studies revealed metastasis of squamous cell carcinoma. The control  echocardiography showed decrease in pulmonary hypertension. No  evidence of right ventricular mass was detected. Conclusion. Cardiac metastasis should be included in the differential diagnosis in patients with complaints of dyspnea and chest pain, especially in cases with history of cancer. Surgical treatment of cardiac metastasis  contributes to the prevention of cardiopulmonary complications and  improvement of survival rates in this group of patients.

Primary Cardiac Tumors: A Retrospective Study

2019 ◽  
Vol 15 (1) ◽  
pp. 57-61
Author(s):  
Mona Mlika ◽  
Nouha Daoud ◽  
Emna Braham ◽  
Adel Marghli ◽  
Faouzi El Mezni
Keyword(s):  
Surgical Resection ◽  
Microscopic Examination ◽  
Malignant Tumors ◽  
Ultra Sound ◽  
Benign Tumors ◽  
Cardiac Tumors ◽  
Postoperative Arrhythmia ◽  
Cardiac Lesions ◽  
The Right ◽  
Primary Cardiac Tumors

Objectives:Primary cardiac tumors are rare and account for 0.001 to 0.03% of cardiac lesions. The authors aim to describe the clinical, the microscopic and the therapeutic characteristics of these tumors through a 13-year-experience in order to highlight the diagnostic challenges faced.Methods:We report 10 primary cardiac tumors diagnosed in the Departments of Pathology and Thoracic Surgery of the same hospital through a 13-year-period.Results:Our study was conducted on 7 women and 3 men. The mean age of the patients was 54.22 years (average, 12 to 79 years). Dyspnea represented the most frequent symptom. Physical examination was normal in all patients. Trans-thoracic ultra-sound examination was performed in all patients. Cardiac MRI allowed localizing the tumors in 2 patients. They were located into the left auricle (6 cases), the right auricle (1 case) and the pericardium (3 cases). The microscopic examination was concluded to myxoma (7 cases), haemangioma (2 cases) and hemangioendothelioma (1 case). Surgical resection was possible in 9 patients. It was impossible in the case of hemangioendothelioma because of the adherence. One death was recorded secondary to postoperative arrhythmia. The other patients presented no complications after a follow-up period ranging from 2 months to 5 years.Conclusion:Cardiac tumors are challenging in their diagnosis and management. A positive diagnosis is based on microscopic examination. Surgical treatment plays a key role and is possible in the majority of benign tumors. The prognosis of malignant tumors remains poor even if a complete surgical resection is possible.

scholarly journals Durable Response to Immunotherapy With Antiangiogenic Drug in Large-Cell Lung Carcinoma With Multiple Fulminant Postoperative Metastases: A Case Report

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhilin Luo ◽  
Hong Zhang ◽  
Yajie Xiao ◽  
Rui Wang ◽  
Liping Zhang ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Neuron Specific Enolase ◽  
Gene Mutations ◽  
Lower Lobe ◽  
Large Cell ◽  
Upper Arm ◽  
Durable Response ◽  
Cell Lung Carcinoma ◽  
The Right ◽  
Antiangiogenic Drug

Immunotherapy alone or chemo-immunotherapy has recently been recommended for treating advanced lung carcinoma in patients without driver mutations. However, the efficacy of immunotherapy and molecular mechanism in large-cell lung cancer (LCLC) remains unclear. Here, we reported a rare case of multiple fulminant postoperative body and mouth metastases in LCLC treating with combination immunotherapy. Initially, the patient was diagnosed as early stage LCLC and underwent a radical resection of the right lower lobe. Just one month later, multiple fulminant body and mouth lesions appeared in the right upper arm, right elbow, right waist, and tongue root. Meanwhile, serum neuron specific enolase (NSE) concentration dramatically increased from 12.12 to 30.14 ng/ml. Immumohistochemistry findings demonstrated moderate PD-L1 expressions with tumor proportion score (TPS), while next-generation sequencing indicated moderate tumor mutational burden (TMB) levels and gene mutations in PBRM1 L1230P and TP53 L194R of both foci. Besides, loss of heterozygosity (LOH) at human leukocyte antigen (HLA) class I (HLA-A*02:03, HLA-B*55:02 and HLA-C*12:03) were detected in the right upper arm metastasis, which may facilitate malignant postoperative metastases in this case. Notably, this patient received combination therapy with anti-PD-1 antibody sintilimab plus anlotinib, and achieved a partial response for at least 12 months. Using an integrated computational method, the mutant peptide TEIPENDIPL derived from PBRM1 L1230P was predicted to be a specific neoantigen and could still be presented by HLA-B*40:01. This case suggests that immunotherapy plus antiangiogenic drug may provide an alternative therapeutic option for advanced LCLC patients without common gene mutations.

scholarly journals Cardiac metastases from primary myxoid liposarcoma of the thigh: A case report

2020 ◽  
Author(s):  
Kunihiro Ikuta ◽  
Tomohisa Sakai ◽  
Hiroshi Koike ◽  
Tohru Okada ◽  
Siro Imagama ◽  
...  
Keyword(s):  
Metastatic Disease ◽  
Abdominal Cavity ◽  
Surgical Excision ◽  
Myxoid Liposarcoma ◽  
Wide Resection ◽  
Cardiac Metastasis ◽  
Dismal Prognosis ◽  
Disease Case ◽  
Cardiac Metastases ◽  
The Right

Abstract Background: Myxoid liposarcoma is well known to have an unusual proclivity for extrapulmonary metastasis. However, cardiac metastasis of myxoid liposarcoma is very rare, even in patients with advanced disease. Case presentation: A 40-year-old man was diagnosed with myxoid liposarcoma of the right thigh and treated with wide resection. Two years after the surgery, a low-density area in the left ventricle was found on follow-up chest computed tomography, which was suspected of being metastatic disease. He underwent surgical treatment, and the lesion was pathologically confirmed as metastasis of myxoid liposarcoma. Fifteen months later, he complained of slight dyspnea and developed metastatic disease in the right atrium. He was treated with surgical excision for the disease, followed by radiotherapy. Although there has been no recurrence in the heart since the second cardiac metastasectomy, multiple metastases have occurred in the abdominal cavity, lungs, and muscles. He finally died of the disease at two years after the second cardiac metastasectomy. Conclusion: We experienced a case of primary myxoid liposarcoma in the thigh, accompanied by ectopic and metachronous cardiac metastases. Despite its dismal prognosis, surgical excision occasionally offers a chance to prolong survival in patients with no evidence of widespread metastases.

scholarly journals Cardiac Angiosarcoma:A case report and review of the literature

2021 ◽  
Author(s):  
Limin Luo ◽  
Weipeng Zhao ◽  
Kun Liu
Keyword(s):  
Case Report ◽  
Malignant Tumors ◽  
Right Atrial ◽  
Cardiac Tumors ◽  
Review Of The Literature ◽  
Primary Tumors ◽  
Cardiac Angiosarcoma ◽  
Right Atrial Appendage ◽  
The Right ◽  
Primary Cardiac Tumors

Primary cardiac tumors are extremely rare.Most primary tumors are benign,and malignant tumors comprise about 15%1.Angiosarcoma is the most common type of primary cardiac malignant tumors.Compared with the left atrium or ventricle,the tumor prefer to occur in the right atrium or ventricle,especially the right atrium.In this case report,we present the case of a 32-year-old female with cardiac angiosarcoma primary to the right atrial appendage(RAA).

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