scholarly journals SURGICAL CORRECTION OF CARDIAC METASTASES FROM CERVICAL CANCER

2018 ◽  
Vol 17 (3) ◽  
pp. 109-114
Author(s):  
V. M. Shipulin ◽  
S. L. Andreev ◽  
A. S. Pryakhin ◽  
V. V. Shipulin ◽  
L. N. Bondar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Pulmonary Hypertension ◽  
Surgical Treatment ◽  
Right Ventricular ◽  
Cancer Metastasis ◽  
External Beam Radiotherapy ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Right Ventricular Mass ◽  
Cardiac Metastases

Metastases to the heart are extremely rare, and the reported incidence of cardiac metastasis at autopsy ranges from 1.5 to 21.8  %. In cancer patients, cardiac metastases are usually difficult to  diagnose unless the patients do not complain of any related  symptoms. Common tumors with cardiac metastasis potential are  usually carcinomas of the lung, breast, and malignant lymphoma.  The prognosis of a metastatic heart tumor is unfavorable. The  average life expectancy for patients with this diagnosis is less than  six months. In addition, surgical treatment of primary cardiac tumors or metastatic cardiac tumors is associated with high risk of  perioperative lethality. Case report. We present a rare case of  cervical cancer metastasis to the heart in a 33-year-old woman.  Cytological examination revealed no evidence of disease recurrence  14 months after the completion of external beam radiotherapy.  Echocardiography showed a mass in the outflow tract of the right ventricle and findings of severe pulmonary hypertension.  omputed tomography and magnetic resonance imaging revealed a  large right ventricular thrombus. The patient underwent surgery with  artificial circulation. Pathohistological and immunohistochemical studies revealed metastasis of squamous cell carcinoma. The control  echocardiography showed decrease in pulmonary hypertension. No  evidence of right ventricular mass was detected. Conclusion. Cardiac metastasis should be included in the differential diagnosis in patients with complaints of dyspnea and chest pain, especially in cases with history of cancer. Surgical treatment of cardiac metastasis  contributes to the prevention of cardiopulmonary complications and  improvement of survival rates in this group of patients.

scholarly journals Intracardiac Metastasis from a Large Cell Neuroendocrine Lung Carcinoma

2019 ◽  
Vol 08 (01) ◽  
pp. e41-e43
Author(s):  
Christopher Gaisendrees ◽  
Kaveh Eghbalzadeh ◽  
Navid Mader ◽  
Thorsten C. W. Wahlers
Keyword(s):  
Lung Carcinoma ◽  
Malignant Tumors ◽  
Close Contact ◽  
Large Cell ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Cardiac Metastases ◽  
The Right ◽  
Cava Vein ◽  
Inferior Cava Vein

AbstractPrimary malignant tumors of the heart are rare; the biggest group is sarcomas. Cardiac metastases make up the biggest group of secondary cardiac tumors. We present a rare case of cardiac metastasis (3.1 × 3.2 × 2.8 cm) localized in the right atrium, originating from a large cell neuroendocrine lung carcinoma, with close contact to the tricuspid valve and inferior cava vein.

scholarly journals Biatrial Cardiac Metastases in a Patient with Uterine Cervix Malignant Melanoma

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Caglayan Geredeli ◽  
Melih Cem Boruban ◽  
Necdet Poyraz ◽  
Mehmet Artac ◽  
Alpay Aribas ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Uterine Cervix ◽  
Tissue Characterization ◽  
Primary Melanoma ◽  
Diagnostic Techniques ◽  
Cardiac Metastasis ◽  
Cardiac Tumors ◽  
Malignant Melanomas ◽  
Cardiac Metastases

Primary malignant melanomas of uterine cervix are quite rarely seen neoplasms, and long-life prognosis of patients with this disease is poor. Immunohistochemical methods and exclusion of other primary melanoma sites are used to confirm the diagnosis. As with other melanomas, cervix malignant melanomas may also cause cardiac metastases. Cardiac metastases are among rarely seen but more commonly encountered cases, compared to primary cardiac tumors. Here, we present a case of biatrial cardiac metastases in a 73-year-old patient with uterine cervix malignant melanomas. The patient underwent echocardiography, cardiac magnetic resonance imaging, and computed tomography. Our report shows the importance of advanced diagnostic techniques, such as cardiac magnetic resonance, not only for the detection of cardiac masses, but for a better anatomic definition and tissue characterization. Although the cases of malignant melanomas leading to multiple cardiac metastasis were reported in literature, the metastatic concurrence of malignant melanomas in both right and left atriums is quite rarely encountered as metastatic malignant melanomas. Also, another intriguing point in our case is that the primary lesion of our case was stemmed from uterine cervix, but not skin.

A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model

2002 ◽  
Vol 80 (4) ◽  
pp. 269-274 ◽  
Author(s):  
Laimute Taraseviciene-Stewart ◽  
Lajos Gera ◽  
Peter Hirth ◽  
Norbert F Voelkel ◽  
Rubin M Tuder ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Right Ventricular ◽  
Selection Process ◽  
Pulmonary Arteries ◽  
Normal Lung ◽  
Vegf Receptor ◽  
Caspase Inhibitor ◽  
Severe Pulmonary Hypertension ◽  
Right Ventricular Mass ◽  
Bradykinin Antagonist

Chronically hypoxic rats (exposed to 5000 m elevation for 3 weeks) develop pulmonary hypertension (PH) that is reversed upon return to normoxia and is blocked by bradykinin (BK) antagonist B9430 treatment (100 µg/kg s.c. three times per week). Treatment of rats with both the synthetic VEGF receptor-1/2 antagonist 3-[(2,4-dimethylpyrrol- 5-yl)methylidenyl]-indolin-2-one (SU5416) (200 mg/kg, single s.c. injection) and hypoxia (3 weeks) causes irreversible severe PH characterized by marked elevation of pulmonary artery pressure (PAP), right ventricular hypertrophy, and obliteration of pulmonary arteries by proliferating endothelial cells (EC). Between weeks 1 and 2 of treatment, there is increased apoptotic EC death and caspase-3 activity. The combination of hypoxia with VEGFR-1 and -2 blockade appears to cause death of normal lung EC and proliferation of an apoptosis-resistant proliferating EC phenotype. Cotreatment with BK antagonist B9430 and (or) the broad caspase inhibitor Z-Asp-2,6-dichlorobenzoyloxymethylketone (Z-Asp) (2 mg/kg three times per week) prevented development of severe PH and caused significant reduction of PAP: 39.7 ± 4.6 mmHg in Z-Asp + SU5416, 37.1 ± 1.2 mmHg in BK antagonist B9430 + SU5416, 27.2 ± 0.7 mmHg in Z-Asp alone, and 36.6 ± 3.0 mmHg in BK antagonist alone versus 48 ± 1.7 mmHg in SU5416-treated rats and 32.8 ± 1.4 mmHg in vehicle-treated controls. The PAP correlated with the right ventricular mass. Pulmonary arteries of rats treated with Z-Asp and BK antagonist B9430 had a marked reduction of intravascular EC, yet there was still evidence of medial muscular hypertrophy, similar to that observed in chronically hypoxic rats not treated with SU5416. We conclude that EC death induced by VEGFR-2 blockade with SU5416 may trigger an EC selection process that allows for the expansion of apoptosis-resistant EC, possibly driven by mechanisms independent of VEGF and VEGFR-2.Key words: bradykinin antagonist, severe pulmonary hypertension, vascular endothelial growth factor receptors, apoptosis.

scholarly journals Cervical Cancer With Cardiac Metastasis

2012 ◽  
Vol 28 (6) ◽  
pp. 303-306
Author(s):  
Annette C. Smith ◽  
Mikel D. Smith
Keyword(s):  
Cervical Cancer ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Emission Tomography ◽  
Cardiac Metastasis ◽  
Right Ventricular Mass ◽  
Positron Emission ◽  
Cancer Of The Cervix ◽  
2D Echocardiogram ◽  
The Right

A 48-year-old woman presented with fatigue and vaginal spotting and was subsequently diagnosed with squamous cell cancer of the cervix. Computed tomography and positron emission tomography scans suggested widespread disease including possible involvement of the right ventricle. A 2D echocardiogram with Doppler showed a large right ventricular mass obstructing the tricuspid valve inflow. This report demonstrates the use of echocardiography and Doppler ultrasound in the diagnosis of a rare case of cardiac metastasis from cervical cancer.

Multi-Parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: A Prospective Multicenter Study

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 4564-4564
Author(s):  
Alessia Pepe ◽  
Antonella Meloni ◽  
Pietro Giuliano ◽  
Maria Giovanna Neri ◽  
Giovanni Palazzi ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Multivariate Analysis ◽  
Magnetic Resonance ◽  
Iron Overload ◽  
Right Ventricular ◽  
Cardiac Complications ◽  
Thalassemia Intermedia ◽  
Independent Predictive Factor ◽  
Ventricular Mass ◽  
Right Ventricular Mass

Abstract Introduction: Cardiovascular Magnetic Resonance (CMR) has an established role in managing and predicting prognosis of patients with Thalassemia Major (TM). Thalassemia Intermedia (TI) is a milder variant of beta-thalassemia showing a different clinical and prognostic profile; pulmonary hypertension (PH) is a more common complication in TI patients. We prospectively determined the predictive value of CMR parameters, including measurement of right ventricular mass, for cardiac complications in TI. Methods: We considered 342 TI patients enrolled in the Myocardial Iron Overload in Thalassemia network; about half of them (178/302, 58.9%) were transfusion-dependent. Myocardial and liver iron overload were measured by T2* multiecho technique. Atrial dimensions, left and right ventricular mass and systolic function were quantified by cine images. Late gadolinium enhancement (LGE) images were acquired to detect myocardial fibrosis. Results: Twenty-three patients were excluded because a cardiac complication was present at the time of first CMR, so we prospectively followed 319 patients. All 319 patients were white, with a mean age at time of their first scan of 38.02±11.69 years and 165 (51.7%) of them were females. Mean follow-up time was 52.24±24.87 months (median 54.64 months). Cardiac events were recorded in 22 patients (6.9%): heart failure (HF) in 1 patient, arrhythmias in 12 patients, pulmonary hypertension (PH) in 7 patients and myocardial infarction (MI) in 2 patients. Due to the low number of events, only arrhythmias, PH and cardiac complications globally considered were taken as cardiac outcomes for univariate and multivariate analysis. In the multivariate analysis RV hypertrophy was the only independent predictive factor for arrhythmias (HR=33.83, 95% CI=6.07-188.74, P<0.0001) and PH (HR=73.33, 95% CI=10.00-537.57, P<0.0001). When cardiac complications were considered all together, RV hypertrophy (HR=24.12, 95% CI=5.09-114.12, P<0.0001) and myocardial fibrosis by LGE (HR=6.59, 95% CI=1.33-32.67, P=0.021) were independent prognostic factors in the multivariate analysis. The Figures display the Kaplan-Meier curves showing the impact of the independent predictive factors on each outcome. Conclusions: For the first time we studied the prognostic value of right ventricular mass as part of multiparametric CMR imaging in a population of TI patients. RV hypertrophy identified patients at high risk for arrhythmias and PH. Both RV hypertrophy and fibrosis detected by LGE were independent predictive factor for cardiac complications. Measurement of RV mass should be part of the multi-parametric CMR study of patient with thalassemia intermedia. Figure 1. Figure 1. Disclosures Pepe: ApoPharma Inc: Speakers Bureau; Novartis: Speakers Bureau; Chiesi: Speakers Bureau.

scholarly journals Diagnosis of cardiac metastasis from cervical cancer in a 33-year-old patient using multimodal imaging studies: a case report and literature review

2014 ◽  
Vol 3 (8) ◽  
pp. 204798161453028 ◽  
Author(s):  
Khoschy Schawkat ◽  
Beatrix Hoksch ◽  
Markus Schwerzmann ◽  
Stefan Puig ◽  
Thorsten Klink
Keyword(s):  
Cervical Cancer ◽  
Interventricular Septum ◽  
Emergency Admission ◽  
Ct Scanning ◽  
Cardiac Metastasis ◽  
Curative Therapy ◽  
Complete Work ◽  
Cardiac Metastases ◽  
Magnetic Resonance Imaging Mri ◽  
Enhanced Computed Tomography

We report a case of a 33-year-old woman with emergency admission due to dyspnoea and fever. History included squamous cell carcinoma of the cervix in complete remission. Contrast-enhanced computed tomography (CT) scanning of the chest, which was indicated to rule out pneumonia, revealed an infiltrative cardiac mass. Further assessment of the tumour by echocardiography and cardiac magnetic resonance imaging (MRI) showed transmural infiltration of the apical interventricular septum with a mass extending into the left and right ventricle cavities. The mass was highly suspicious for a cardiac metastasis. Cardiac metastases from cervical cancer are extremely rare. Recurrence of cervical carcinoma involving the heart should be considered even after a curative therapy approach. Non-invasive imaging plays a paramount role in investigating cardiac masses. Echocardiography, CT and MRI are complementary imaging modalities for complete work-up of intracardiac lesions.

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