scholarly journals A Case Series of Fetal Valproate Syndrome in the Republic of Crimea

2019 ◽  
Vol 10 (04) ◽  
pp. 700-702 ◽  
Author(s):  
Olga Nikolaevna Rybalko ◽  
Nikolai Nikolaevich Kaladze ◽  
Irina Alexandrovna Sukhareva ◽  
Ching Soong Khoo
Keyword(s):  
Valproic Acid ◽  
Congenital Malformations ◽  
Case Series ◽  
Dysmorphic Features ◽  
Fetal Valproate Syndrome ◽  
Lack Of Information ◽  
The Republic

AbstractValproic acid or valproate is a well-recognized potent teratogen. Antenatal exposure to this drug can cause fetal valproate syndrome (FVS), which is a constellation of distinctive dysmorphic features and congenital malformations. Despite an abundance of reports and registries about this syndrome, there is lack of information from Russia, in particular, the Republic of Crimea. We herein describe two cases of FVS from our registry.

scholarly journals Valproic acid during pregnancy: Case report of a child with congenital malformations due to fetal valproate syndrome, and a high unbound serum level of valproic acid at birth

2017 ◽  
Vol 04 (01) ◽  
pp. 094-097 ◽  
Author(s):  
Shirley Sparla ◽  
Paul Hogeman ◽  
Maarten van Gemert ◽  
Eleonora Swart ◽  
Mirte Malingre
Keyword(s):  
Valproic Acid ◽  
Case Report ◽  
Serum Level ◽  
Real Time ◽  
Therapeutic Range ◽  
Congenital Malformations ◽  
Serum Levels ◽  
Postnatal Period ◽  
Total Serum ◽  
Fetal Valproate Syndrome

AbstractWe present a child in utero exposed to valproic acid with congenital malformations due to fetal valproate syndrome and with toxic effects. Directly postnatal, a high-unbound serum level of valproic acid was measured. The total serum level of valproic acid was in the therapeutic range. Measuring unbound serum levels during pregnancy and postnatal period in the child provides more information about real-time exposure than measuring total serum levels.

scholarly journals Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature

2021 ◽  
Vol 13 (1) ◽  
pp. 98-103
Author(s):  
Agnieszka Pawłowska-Kamieniak ◽  
Paulina Krawiec ◽  
Elżbieta Pac-Kożuchowska
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Metabolic Disorders ◽  
Genetic Factors ◽  
Clinical Symptoms ◽  
Gallstone Disease ◽  
Young Patients ◽  
Case Series ◽  
Review Of The Literature ◽  
Acid Therapy

Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP.

scholarly journals Fetal Valproate Syndrome – A Case Report

2018 ◽  
Vol 1 (1) ◽  
Keyword(s):  
Valproic Acid ◽  
Female Child ◽  
Autism Spectrum ◽  
Facial Dysmorphism ◽  
In Utero Exposure ◽  
Fetal Valproate Syndrome ◽  
Drug History ◽  
Case Characteristics ◽  
Convulsant Drug ◽  
In Pregnancy

Background: Fetal Valproate Syndrome (FVS) results from prenatal exposure to valproic acid (VPA). Case characteristics: A four year old female child presented with facial dysmorphism and features of autism spectrum disorder (ASD). She had in-utero exposure to valproic acid (VPA). Message: VPA to be avoided in pregnancy and in Dysmorphism or ASD children maternal anti- convulsant drug history must be taken.

Impacts of Visa Policy on Inbound Tourism in Kazakhstan

2021 ◽  
Vol 1 (59) ◽  
Author(s):  
Akbota Abdrakhman
Keyword(s):  
Asian Country ◽  
Application Process ◽  
Lack Of Information ◽  
Central Asian ◽  
Maximum Benefit ◽  
Inbound Tourism ◽  
Visa Application ◽  
Visa Policy ◽  
The Republic ◽  
And Migration

Every destination in the world tries to create affordable conditions for tourists to get the maximum benefit from international tourism and one of these conditions is accessibility, which refers to the visa policy of a country. An effective and appropriate visa policy makes travel destinations more attractive and easily accessible to visit. This research focuses on the visa policy of Central Asian country – the Republic of Kazakhstan and reveals several problems related to it, such as lack of information on the visa application process, especially on e-visa, raw systemized visa and migration portal, a long list of visa-needed countries, plenty of refusals in invitation letters by Migration Police and existence of huge visa restrictions for some countries. The current visa policy makes the Republic of Kazakhstan less open to foreigners and less competitive among other countries. Based on a literature review on visa policy and its effects on the economy and tourism sector in a destination and by using comparative analysis of visa policies of two Central Asian countries – Kazakhstan and Uzbekistan, several problems that affect inbound tourism, as well as recommendations for improvement of visa policy for Kazakh government are discussed in this research.

First trimester exposure to aripiprazole and the risk of congenital malformations; a case series

2015 ◽  
Vol 57 ◽  
pp. 217
Author(s):  
Hannah J. Dunstan ◽  
Jonathan L. Richardson ◽  
Amanda J. Greenall ◽  
Dacia Jones ◽  
Sally Stephens ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Case Series ◽  
First Trimester ◽  
Trimester Exposure

scholarly journals Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs

Neurology ◽  
2019 ◽  
Vol 93 (2) ◽  
pp. e167-e180 ◽  
Author(s):  
Pierre-Olivier Blotière ◽  
Fanny Raguideau ◽  
Alain Weill ◽  
Elisabeth Elefant ◽  
Isabelle Perthus ◽  
...  
Keyword(s):  
Health Care ◽  
Valproic Acid ◽  
Antiepileptic Drugs ◽  
Congenital Malformations ◽  
Cleft Lip ◽  
Reference Group ◽  
The Other ◽  
Increased Risk ◽  
Exact Confidence Intervals ◽  
Major Congenital Malformations

ObjectiveTo assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AEDs) during the first 2 months of pregnancy and the risk of 23 major congenital malformations (MCMs).MethodsThis nationwide cohort study, based on the French health care databases, included all pregnancies ≥20 weeks and ending between January 2011 and March 2015. Women were considered to be exposed when an AED had been dispensed between 1 month before and 2 months after the beginning of pregnancy. The reference group included pregnant women with no reimbursement for AEDs. MCMs were detected up to 12 months after birth (24 months for microcephaly, hypospadias, and epispadias). Odds ratios (ORs) were adjusted for potential confounders for MCMs with at least 5 cases. Otherwise, we calculated crude ORs with exact confidence intervals (CIs).ResultsThe cohort included 1,886,825 pregnancies, 2,997 of which were exposed to lamotrigine, 1,671 to pregabalin, 980 to clonazepam, 913 to valproic acid, 579 to levetiracetam, 517 to topiramate, 512 to carbamazepine, 365 to gabapentin, 139 to oxcarbazepine, and 80 to phenobarbital. Exposure to valproic acid was associated with 8 specific types of MCMs (e.g., spina bifida, OR 19.4, 95% CI 8.6–43.5), and exposure to topiramate was associated with an increased risk of cleft lip (6.8, 95% CI 1.4–20.0). We identified 3 other signals. We found no significant association for lamotrigine, levetiracetam, carbamazepine, oxcarbazepine, and gabapentin.ConclusionsThese results confirm the teratogenicity of valproic acid and topiramate. Because of the small numbers of cases and possible confounding, the other 3 signals should be interpreted with appropriate caution.

The Effect Of Knowledge Management System For Academic Services With SECI Model

2020 ◽  
Vol 4 (1) ◽  
pp. 80-88
Author(s):  
Nur Pusparini ◽  
◽  
Agus Budiyantara ◽  
Sofian Lusa ◽  
Keyword(s):  
Knowledge Management ◽  
Management System ◽  
Knowledge Management System ◽  
Acceptance Test ◽  
Knowledge Process ◽  
Seci Model ◽  
Academic Position ◽  
Lack Of Information ◽  
The Republic ◽  
The One

Based on the 1945 Constitution of the Republic of Indonesia – Article 37 of 2009 verse 8 states that a lecturer profession obliges to a minimum of 12 and maximum of 16 teaching credits in every semester according to his/her academic qualifications. Todays, Institute of Information Management and Computer Science (STMIK) Widuri has been applying a sharing knowledge process amid lecturers with the intention to assist them in academic position ladder management. However, problems are found during its implementation. First problem is infrequentTri Dharma practices (three principles of higher education; education, research and contribution to society)and reports being submitted by lecturers; the condition has resulted a statistic of STMIK active lecturers in general to decrease to 41.6%. Lack of information regarding Tri Dharma practices and its administrations known by its lecturers is the one missed to solve; a lecturer does not comprehensively understand what the stages are required in order to administer their academic position ladder. Second issue is there has been no media to facilitate lecturers to spread and share the knowledge and experience with the other fellow lecturers that the process of levelling up their academic tenures or positions become hampered. This means, the slower the process the longer it takes for them to move up to the next academic position ladder. As this is the case, the researchers propose aprototype of knowledge management system (KMS) utilizing SECI methodand gathering data through interviews, observations as well as literature studies. Software used is User Acceptance Test (UAT). Furthermore, the research has come up with a web-based KSM prototype with test percentage result76%; this means the system is accepted and matched the expectation.

Acute pancreatitis in children from Valproic acid: case series and review

2003 ◽  
Vol 28 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Nancy L Grauso-Eby ◽  
Olga Goldfarb ◽  
Lori B Feldman-Winter ◽  
Gary N McAbee
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Case Series
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