Intensification of Free-Radical Racemization for a Non-activated Amine in a Continuous Flow Reactor

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3389-3396
Author(s):  
Frédéric C. Toussaint ◽  
Thierry Defrance ◽  
Serge Decouvreur ◽  
Nicolas Carly ◽  
Alain Merschaert
Keyword(s):  
Free Radical ◽  
Pharmaceutical Industry ◽  
Chiral Separation ◽  
Process Design ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Flow Mode ◽  
Environmental Footprint ◽  
Radical Initiator ◽  
Continuous Flow Reactor

The free-radical racemization of non-activated amines is a powerful tool for process design in the pharmaceutical industry, allowing the recycling of undesired enantiomers after chiral separation. This paper describes the development of the free-radical racemization of a key API intermediate in a continuous flow reactor. Upon development, a significant reduction of the solvent usage and radical initiator was made possible thanks to the conversion into a continuous flow mode. This intensification positively impacted both the environmental footprint and the safety of the reaction as well as maintaining satisfactory productivity.

scholarly journals Continuous flow synthesis of poly(acrylic acid) via free radical polymerisation

2017 ◽  
Vol 2 (5) ◽  
pp. 662-668 ◽  
Author(s):  
Laurens Brocken ◽  
Paul D. Price ◽  
Jane Whittaker ◽  
Ian R. Baxendale
Keyword(s):  
Free Radical ◽  
Acrylic Acid ◽  
Aqueous Solutions ◽  
Residence Time ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Initiator Concentration ◽  
Reaction Parameters ◽  
Continuous Flow Reactor ◽  
Radical Polymerisation

The free radical polymerisation of aqueous solutions of acrylic acid (1) has been studied using a continuous flow reactor to quickly screen reaction parameters such as temperature, residence time, monomer- and initiator concentration.

Renewable Energy from Agricultural Waste

2018 ◽  
Vol 69 (6) ◽  
pp. 1363-1366 ◽  
Author(s):  
Stefania Daniela Bran ◽  
Petre Chipurici ◽  
Mariana Bran ◽  
Alexandru Vlaicu
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Gas Chromatography ◽  
Continuous Flow ◽  
Laboratory Experiments ◽  
Fermentation Process ◽  
Flow Reactor ◽  
Agricultural Waste ◽  
Continuous Flow Reactor ◽  
Natural Support ◽  
Co2 Flow

This paper has aimed at evaluating the concentration of bioethanol obtained using sunflower stem as natural support, molasses as carbon source and Saccharomyces cerevisiae yeast in a continuous flow reactor. The natural support was tested to investigate the immobilization/growth of S. cerevisiae yeast. The concentration of bioethanol produced by fermentation was analyzed by gas chromatography using two methods: aqueous solutions and extraction in organic phase. The CO2 flow obtained during the fermentation process was considered to estimate when the yeast was deactivated. The laboratory experiments have highlighted that the use of plant-based wastes to bioconversion in ethanol could be a non-pollutant and sustainable alternative.

Thermocatalytic Hydrodeoxygenation and Depolymerization of Waste Lignin to Oxygenates and Biofuels in a Continuous Flow Reactor at Atmospheric Pressure

2020 ◽  
Vol 8 (35) ◽  
pp. 13195-13205 ◽  
Author(s):  
Swathi Mukundan ◽  
Daria Boffito ◽  
Abhijit Shrotri ◽  
Luqman Atanda ◽  
Jorge Beltramini ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Continuous Flow Reactor

scholarly journals Development of a tubular continuous flow reactor for the investigation of improved gas–solid interaction in photocatalytic CO2 reduction on TiO2

2019 ◽  
Vol 18 (2) ◽  
pp. 314-318 ◽  
Author(s):  
Martin Dilla ◽  
Ahmet E. Becerikli ◽  
Alina Jakubowski ◽  
Robert Schlögl ◽  
Simon Ristig
Keyword(s):  
Gas Phase ◽  
Continuous Flow ◽  
Flow Reactor ◽  
Tubular Reactor ◽  
Co2 Reduction ◽  
Continuous Flow Reactor ◽  
Reactor Geometry

Newly developed tubular reactor geometry allows intensive gas–solid interaction in photocatalytic gas-phase CO2 reduction.

Design of a novel continuous flow reactor for low pH viral inactivation

2017 ◽  
Vol 115 (3) ◽  
pp. 606-616 ◽  
Author(s):  
Stephanie A. Parker ◽  
Linus Amarikwa ◽  
Kevin Vehar ◽  
Raquel Orozco ◽  
Scott Godfrey ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Reactor ◽  
Low Ph ◽  
Viral Inactivation ◽  
Continuous Flow Reactor

Stability of the first-generation Grubbs metathesis catalyst in a continuous flow reactor

2006 ◽  
Vol 691 (24-25) ◽  
pp. 5197-5203 ◽  
Author(s):  
Zenon Lysenko ◽  
Bob R. Maughon ◽  
Tezi Mokhtar-Zadeh ◽  
Michael L. Tulchinsky
Keyword(s):  
Continuous Flow ◽  
First Generation ◽  
Flow Reactor ◽  
Continuous Flow Reactor ◽  
Metathesis Catalyst
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