scholarly journals Fulminant Wegener's granulomatosis: A case report

2013 ◽  
Vol 70 (9) ◽  
pp. 887-890 ◽  
Author(s):  
Miroslav Dinic ◽  
Lidija Kandolf-Sekulovic ◽  
Lidija Zolotarevski ◽  
Rados Zecevic
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Systemic Vasculitis ◽  
Bowel Perforation ◽  
Exploratory Laparotomy ◽  
Unknown Etiology ◽  
Diffuse Peritonitis ◽  
Skin Sample ◽  
Skin Ulcers ◽  
Hemorrhagic Bullae

Introduction. Granulomatosis Wegener is anti-neutrophil cytoplasmic antibodies (ANCAs)-associated systemic vasculitis of unknown etiology. It is manifested as granulomatous necrotizing inflammation of the upper and lower parts of the respiratory tract, glomerulonephritis and systemic vasculitis involving most frequently the skin and oral mucous membrane. Sera markers of this disease are c-ANCA and p-ANCA. Case report. We presented a female patient aged 52 years with purpuric spots that had appeared on the lower legs ten months before admission to our hospital. The disease ran an aggressive course, and a month before admission hemorrhagic bullae, skin ulcers, hoarseness, dyspnea, generalized arthralgia, fatigue and fever had rapidly developed. Histopathological examination of a skin sample revealed necrotizing vasculitis, so that sera markers concentrations were elevated (c-ANCA, p-ANCA). There was a perforation of the nasal septum found on rhinoscopy. During hospitalization acute abdominal pain occurred, a possible tumor in the small intestine and possible granulomas in the liver were seen by multislice computed tomography (MSCT) examination, with normal findings on the lungs and kidneys. The treatment started with methylprednisolone: 500 mg/d i.v. infusion for consecutive 3 days, then 60 mg/d. On exploratory laparotomy small bowel perforation and diffuse peritonitis were found. Unstable in the postoperative period, the patient died on the day 12 of hospitalization. Conclusion. The reported patient was with fulminant Wegener?s granulomatosis, dominantly with skin changes and with gastrointestinal manifestation. This case accents the need for rapid systemic clinical evaluation in a severely ill patient with unclear diagnosis.

scholarly journals Sinonasal Sarcoidosis: A Case Report

2016 ◽  
Vol 15 (4) ◽  
pp. 648-650
Author(s):  
Afroza Khanam ◽  
Gulshan Akhtar ◽  
Nabila Khanduker ◽  
Nurun Nahar Chowdhury ◽  
Mohammad Abdur Rahman ◽  
...  
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Medical Science ◽  
Neck Region ◽  
Pulmonary Involvement ◽  
Unknown Etiology ◽  
Nasal Discharge ◽  
Diagnostic Challenge ◽  
Current Case ◽  
Nasal Blockage

Sarcoidosis is a chronic granulomatous disease of unknown etiology which principally affects the lower respiratory tract & lungs. Sarcoidosis in the head & neck region is infrequent. Isolated sino nasal sarcoidosis without pulmonary involvement is rare.Case: An 18 years old male patient presented with the complaints of nasal blockage, purulent nasal discharge which was occasionally blood stained for 6 months, deformity of nose, swelling of face & lips for 4 months & watering of eyes for same duration. Endoscopy of nose revealed intra nasal mucosal thickening which was friable & bleeds on touch. The diagnosis of sino nasal sarcoidosis was made by histopathological examination of nasal biopsy specimen.Conclusion: Sino nasal sarcoidosis is a disease of diagnostic challenge to the clinician as its mimicking clinical features may be misleading & cause delay in definitive diagnosis. In the current case report, we presented a case of sino nasal sarcoidosis presenting as chronic rhino sinusitis.Bangladesh Journal of Medical Science Vol.15(4) 2016 p.648-650

scholarly journals The importance of histopathology in the diagnosis of isolated renal sarcoidosis: a case report

2018 ◽  
Vol 40 (3) ◽  
pp. 291-295
Author(s):  
João Onofre Trindade Filho ◽  
Kaline Daniele de Souza Amaro ◽  
Allana Desirée Teixeira de Oliveira ◽  
Cecília Neta Alves Pegado Gomes ◽  
Hermann Ferreira Costa ◽  
...  
Keyword(s):  
Case Report ◽  
Medical Records ◽  
Clinical Laboratory ◽  
Histopathological Examination ◽  
Laboratory Data ◽  
Rare Condition ◽  
Unknown Etiology ◽  
Renal Manifestation ◽  
Systemic Inflammatory Disease ◽  
Rule Out

ABSTRACT Introduction: Sarcoidosis is a systemic inflammatory disease of unknown etiology, characterized by the presence of non-caseating granulomas in several organs; renal impairment alone is a rare condition. When it affects the kidneys, the most prevalent manifestations are hypercalcemia and hypercalciuria. This paper aims to address the topic of renal sarcoidosis, by means of a case report, and reinstate the importance of histopathology in its diagnosis. Methods: The data came from an observational clinical study with a qualitative approach, through an interview with the renal sarcoidosis patient and data from her medical records. Case report: Patient D.M.S., 50 years old, Caucasian, presented with reddish eyes and body pains lasting for fifteen days as first manifestations of the disease. Upon kidney ultrasound scan, we found renal parenchymal nephropathy. Serial renal function and metabolic tests reported anemia and progressive urea and creatinine changes, as well as hypercalcemia and hypercalciuria, confirming acute kidney failure (AKF). A histopathological examination suggested the diagnosis, which was confirmed by clinical, laboratory and histopathological data. There was therapeutic resolution after steroid therapy. Discussion: The symptomatology of sarcoidosis is diverse and often non-specific. Renal manifestation, which usually occurs after organ involvement, is present in less than 5% of patients, and about 1% to 2% of these patients may develop AKF. Conclusions: The use of histopathology together with clinical and laboratory data to diagnose isolated renal sarcoidosis, rule out other etiologies and introduce early treatment is of paramount importance.

scholarly journals Dysplasia epiphysealis hemimelica: A case report

2014 ◽  
Vol 71 (11) ◽  
pp. 1081-1084
Author(s):  
Dalibor Jovanovic ◽  
Milena Ilic ◽  
Milos Milosavljevic ◽  
Zorica Mihajlovic ◽  
Radisa Vojinovic ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Ankle Joint ◽  
Developmental Disorder ◽  
Histopathological Examination ◽  
Sporadic Case ◽  
Unknown Etiology ◽  
Histological Findings ◽  
Tarsal Bone ◽  
Dysplasia Epiphysealis Hemimelica

Introduction. Dysplasia epiphysealis hemimelica, also known as Trevor?s disease, is an extremely rare skeletal developmental disorder of unknown etiology, characterized by an osteocartilaginous outgrowth of one or more epiphyses or of a tarsal bone during childhood. Case report. We presented a sporadic case of dysplasia epiphysealis hemimelica developed in the talus. A 6- year-old boy complained of swelling of his right ankle joint, with painful and reduced movements. Radiographies suggested excessive overgrowth of the dorsomedial aspect of the talus. The tumor was surgically excised and the gross and histological findings were consistent with those of osteochondroma. Conclusion. Dysplasia epiphysealis hemimelica is diagnosed by clinical, radiographic and histopathological examination. Early diagnosis is important for the condition to be treated before the deformity becomes disabling.

scholarly journals Pneumoperitoneum due to perforated appendicitis: a rare anatomo-radiologic correlation

2008 ◽  
Vol 21 (3) ◽  
pp. 142-143
Author(s):  
André Luiz Santos Rodrigues ◽  
Marcelino Ferreira Lobato ◽  
Augusto César Santana ◽  
Lucas Crociati Meguins ◽  
Daniel Felgueiras Rolo
Keyword(s):  
Peptic Ulcer ◽  
Severe Sepsis ◽  
Abdominal Pain ◽  
Case Report ◽  
Medical Literature ◽  
Perforated Appendicitis ◽  
Perforated Peptic Ulcer ◽  
Exploratory Laparotomy ◽  
Diffuse Peritonitis ◽  
Diffuse Abdominal Pain

BACKGROUND: Pneumoperitoneum is usually associated with a perforated peptic ulcer. However, perforated appendicits may be evolved on it. In the medical literature, the anatomo-radiologic correlation between them is an uncommon event. CASE REPORT: Man with 56-year-old look for assistance with diffuse abdominal pain and distension associated with fever, vomit and absence of flatus and evacuation for about 14 days. The chest radiography revealed a pneumoperitoneum. Diffuse peritonitis was found during the exploratory laparotomy. Appendectomy, peritoneal cavity cleaning and drainage with tubular drains were carried out. However, severe sepsis occurred and the patient died on the 16th post-operative day with multiple systemic organ failure. CONCLUSION: Although rare as pneumoperitoneum ethiology, acute appendicitis may be thought as it's cause.

scholarly journals Giant angioleiomyoma of uterus masquerading as ovarian tumour: a case report

2019 ◽  
Vol 9 (1) ◽  
pp. 437
Author(s):  
Purnima Bhandari ◽  
Anil C. Humane ◽  
Vaishali S. Deshmukh
Keyword(s):  
Case Report ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Broad Ligament ◽  
Exploratory Laparotomy ◽  
Ovarian Tumour ◽  
Benign Tumour ◽  
Diagnosis And Management ◽  
Rare Benign Tumour

Angioleiomyoma is a rare benign tumour of uterus. We are presenting an unusual case of 45-year-old female with 11 kg giant angioleiomyoma of uterus which was masquerading as ovarian tumour on imaging. Exploratory laparotomy was done which was suggestive of huge lobulated mass arising from the uterus. Hysterectomy with bilateral salpingo-oophorectomy was done. Histopathological examination of specimen was suggestive of uterine subserosal and broad ligament angioleiomyoma of cavernous type. This case is being reported because of its rarity and challenges in diagnosis and management.

scholarly journals Oral focal mucinosis of gingiva - a rare case report and review of literature

2017 ◽  
Vol 5 (1) ◽  
pp. 26
Author(s):  
Chandini Dabbiru ◽  
Raghavendra Mahadev Naik ◽  
Kishore Moturi ◽  
Govind Rajkumar
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Rare Case ◽  
Histopathological Examination ◽  
Excisional Biopsy ◽  
Unknown Etiology ◽  
Review Of Literature ◽  
Soft Tissue Lesion ◽  
Rare Case Report ◽  
Myxoid Degeneration

Oral focal mucinosis (OFM) is a rare soft-tissue lesion of unknown etiology. Clinically it appears as asymptomatic round lesions and histologically, characterized by focal myxoid degeneration of connective tissue with presence of stellate shaped fibroblasts which were also evident in the present case. This case report stresses on the fact that diagnosis of OFM is almost impossible hence diagnosis should be confirmed by histopathological examination following incisional or excisional biopsy. Through this article we present a rare case of one such lesion on the gingiva and enumerate the most characteristic and myxomatous lesions. Thus though rare, OFM must be considered in the differential diagnosis of soft tissue overgrowths in oral cavity. Here, we describe the clinical and histopathological   presentation and subsequent management of OFM in a female patient.

scholarly journals Pedunculated Cecal Lipoma Causing Colo-Colonic Intussusception: A Rare Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Stefanos Atmatzidis ◽  
Grigoris Chatzimavroudis ◽  
Aristidis Patsas ◽  
Basilis Papaziogas ◽  
Spiros Kapoulas ◽  
...  
Keyword(s):  
Case Report ◽  
Preoperative Diagnosis ◽  
Rare Case ◽  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Right Hemicolectomy ◽  
Resected Specimen ◽  
Ascending Colon ◽  
Imaging Studies ◽  
Rare Case Report

Colonic lipomas are uncommon nonepithelial neoplasms that are typically sessile, asymptomatic and incidentally found during endoscopy, surgery, or autopsy. We present a very rare case of a 34-year-old female patient with symptomatic pedunculated cecal lipoma causing intermittent colo-colonic intussusception. Despite adequate imaging studies, definite preoperative diagnosis was not established and the patient underwent exploratory laparotomy. Intraoperatively, intussusception of the cecum into the ascending colon was found and right hemicolectomy was performed. Macroscopic assessment of the resected specimen showed the presence of a giant cecal pedunculated polypoid tumor with features of lipoma, causing intussusception. Histopathological examination confirmed the diagnosis of pedunculated cecal lipoma.

scholarly journals Successful Treatment of Hemorrhagic Bullous Henoch-Schönlein Purpura with Oral Corticosteroid: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Celebi Kocaoglu ◽  
Ramazan Ozturk ◽  
Yasar Unlu ◽  
Fatma Tuncez Akyurek ◽  
Sukru Arslan
Keyword(s):  
Case Report ◽  
Gastrointestinal Tract ◽  
Female Patient ◽  
Oral Corticosteroid ◽  
Systemic Vasculitis ◽  
Immunoglobulin A ◽  
Henoch Schonlein Purpura ◽  
Hemorrhagic Bullae ◽  
Schonlein Purpura ◽  
Henoch Schönlein Purpura

Henoch-Schönlein purpura (HSP) is a vasculitis of small-sized blood vessels, resulting from immunoglobulin-A-mediated inflammation. It is the most common acute systemic vasculitis in childhood and mainly affects skin, gastrointestinal tract, joints, and kidneys. The characteristic rash of HSP consists of palpable purpuric lesions 2 to 10 mm in diameter concentrating in the buttocks and lower extremities. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. This report describes a 4.5-year-old female patient with HSP associated with hemorrhagic bullous lesions.

scholarly journals Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

2020 ◽  
Vol 12 (03) ◽  
pp. 225-229
Author(s):  
Timothy Amos Ekwere ◽  
Uchechukwu Brian Eziagu
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Cell Types ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Human Herpes Virus 8 ◽  
Systemic Symptoms

AbstractCastleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.

scholarly journals Case of BRAF mutant Erdheim-Chester disease presenting with multisystem involvement: A case report

2021 ◽  
Vol 8 (2) ◽  
pp. 136-139
Author(s):  
Nang Hseng Kyio ◽  
Tugce Kıran ◽  
Ali Eser ◽  
Guven Cetin ◽  
Cumali Karatoprak
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Endocrine System ◽  
Clinical Findings ◽  
Unknown Etiology ◽  
Erdheim Chester Disease ◽  
Multisystem Involvement ◽  
Imaging Results ◽  
Erdheim Chester ◽  
Chester Disease

Objective: Erdheim-Chester disease is a rare form of non-Langerhans cell histiocytosis of unknown etiology. It is a multisystemic disease that can involve bones, skin, brain, retroperitoneum, cardiovascular system, endocrine system, and lungs. Diagnosis is made by clinical findings, imaging results, and histopathological examination. BRAFV600E (B-rapidly accelerated fibrosarcoma gene) mutation is found in more than half of the cases. When Erdheim-Chester disease is not considered the differential diagnosis, it is not possible to diagnose and treat. In this case report, an Erdheim-Chester case with symptomatic, multisystem involvement, BRAFV600E mutation, and initiated vemurafenib treatment is presented in the light of literature data.

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