Characteristics of olfactory disorder with and without reported flavor loss

Background: The aim of this study was to determine the reliability and validity of the brief version of Questionnaire of Olfactory Disorders (brief QOD). Methods: A total of 372 patients participated in this study. Olfactory function was examined using the Sniffin’ Sticks test. The brief version of QOD, including 4 items concerning parosmia (QOD-P), 7 items concerning quality of life (QOD-QOL), and 3 visual analog scales to rate disease burden, awareness of the disorder and issues related to professional life (QOD-VAS), was used to assess subjective information on olfactory dysfunction. We evaluated the split-half reliability, internal consistency and validity of the brief QOD. Results: The split-half reliability was 0.60 (QOD-P), 0.87 (QOD-QOL), and 0.66 (QOD-VAS), respectively. The Cronbach’s α coefficient was 0.63 (QOD-P), 0.87 (QOD-QOL), and 0.71 (QOD-VAS), respectively. Olfactory function was found to be associated with QOD-P, QOD-QOL and QOD-VAS. Conclusions: The brief QOD is a suitable scale for the assessment of subjective severity of olfactory dysfunction for purposes such as treatment counseling, disability assessment, treatment control, and research in patients with olfactory disorder.

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Olfactory cleft proteome does not reflect olfactory performance in patients with idiopathic and postinfectious olfactory disorder: A pilot study

Scientific Reports ◽

10.1038/s41598-018-35776-8 ◽

2018 ◽

Vol 8 (1) ◽

Author(s):

Axel Wolf ◽

Laura Liesinger ◽

Stefan Spoerk ◽

Matthias Schittmayer ◽

Doris Lang-Loidolt ◽

...

Keyword(s):

Pilot Study ◽

Olfactory Cleft ◽

Olfactory Disorder

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Clinical Features of Olfactory Disorder Following Common Cold

Olfaction and Taste XI ◽

10.1007/978-4-431-68355-1_258 ◽

1994 ◽

pp. 633-633

Author(s):

Tsunemasa Aiba ◽

Yoshiaki Nakai ◽

Midori Sugiura ◽

Jyunko Mori

Keyword(s):

Clinical Features ◽

Common Cold ◽

Olfactory Disorder

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Olfactory disorder in patients infected with SARS-CoV-2

Journal of Microbiology Immunology and Infection ◽

10.1016/j.jmii.2020.08.010 ◽

2020 ◽

Author(s):

Yung-Feng Yen ◽

Hsin-Hao Lai ◽

Shang-Yih Chan ◽

Vincent Yi-Fong Su ◽

Ting-Fang Chiu ◽

...

Keyword(s):

Olfactory Disorder

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Effects of 30 cases of nervous olfactory disorder treated with acupuncture at three nasal points and scalp acupuncture

World Journal of Acupuncture - Moxibustion ◽

10.1016/j.wjam.2019.05.003 ◽

2019 ◽

Vol 29 (2) ◽

pp. 153-155

Author(s):

Xiao-xiao YU ◽

Guo-chen SHI

Keyword(s):

Scalp Acupuncture ◽

Olfactory Disorder

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Olfactory Disorder in Motor Neuron Disease

Experimental Neurology ◽

10.1006/exnr.1997.6773 ◽

1998 ◽

Vol 150 (2) ◽

pp. 248-253 ◽

Cited By ~ 37

Author(s):

C.H. Hawkes ◽

B.C. Shephard ◽

J.F. Geddes ◽

G.D. Body ◽

J.E. Martin

Keyword(s):

Motor Neuron ◽

Motor Neuron Disease ◽

Olfactory Disorder

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Olfactory disturbances in ageing with and without dementia: towards new diagnostic tools

The Journal of Laryngology & Otology ◽

10.1017/s0022215117000858 ◽

2017 ◽

Vol 131 (7) ◽

pp. 572-579 ◽

Cited By ~ 7

Author(s):

A Gros ◽

V Manera ◽

C A De March ◽

N Guevara ◽

A König ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Neurodegenerative Diseases ◽

Elderly People ◽

Neurodegenerative Disorders ◽

Assessment Tools ◽

Diagnostic Tools ◽

Clinical Settings ◽

Olfactory Disorder ◽

Ageing Populations

AbstractBackground:Olfactory disorders increase with age and often affect elderly people who have pre-dementia or dementia. Despite the frequent occurrence of olfactory changes at the early stages of neurodegenerative disorders such as Alzheimer's disease, olfactory disorders are rarely assessed in daily clinical practice, mainly due to a lack of standardised assessment tools. The aims of this review were to (1) summarise the existing literature on olfactory disorders in ageing populations and patients with neurodegenerative disorders; (2) present the strengths and weaknesses of current olfactory disorder assessment tools; and (3) discuss the benefits of developing specific olfactory tests for neurodegenerative diseases.Methods:A systematic review was performed of literature published between 2000 and 2015 addressing olfactory disorders in elderly people with or without Alzheimer's disease or other related disorders to identify the main tools currently used for olfactory disorder assessment.Results:Olfactory disorder assessment is a promising method for improving both the early and differential diagnosis of Alzheimer's disease. However, the current lack of consensus on which tests should be used does not permit the consistent integration of olfactory disorder assessment into clinical settings.Conclusion:Otolaryngologists are encouraged to use olfactory tests in older adults to help predict the development of neurodegenerative diseases. Olfactory tests should be specifically adapted to assess olfactory disorders in Alzheimer's disease patients.

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Olfactory Disorder is the Specific Symptom to Distinguish Eosinophilic from non-eosinophilic Nasal Polyps

10.21203/rs.3.rs-60539/v1 ◽

2020 ◽

Author(s):

Xiaodan Pan ◽

Yuan Zhang ◽

Chengshuo Wang ◽

Luo Zhang

Keyword(s):

Risk Factors ◽

Nasal Polyps ◽

Disease Duration ◽

Clinical Symptoms ◽

Nasal Congestion ◽

Sinus Surgery ◽

Specific Symptom ◽

Logistic Analysis ◽

Significant Difference ◽

Olfactory Disorder

Abstract Background: Patients with eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) have poorer outcomes after endoscopic sinus surgery and a higher recurrence rate. This study aimed to investigate the profile of clinical symptoms of eCRSwNP and the related risk factors.Methods: We prospectively enrolled 298 CRSwNP inpatients from February 2019 to December 2019. Patients were divided into eCRSwNP and non-eCRSwNP groups based on the percentage of blood eosinophils. Clinical data on questionnaires, visual analogue scale (VAS) scores, and laboratory tests were collected. The differences in clinical symptoms, including nasal congestion, rhinorrhea, olfactory disorders, and head/facial pain, between the two groups were analyzed to identify the influential factors. Logistic analysis and receiver operating characteristic curves were used to determine the diagnostic benefit for the specific symptom in eCRSwNP patients.Results: Of the four major clinical symptoms, nasal congestion and olfactory disorders were significantly different between eCRSwNP and non-eCRSwNP groups. Patients with eCRSwNP more frequently complained about olfactory disorders (P = 0.002), while patients with non-eCRSwNP mostly had nasal congestion (P = 0.001). The logistic analysis showed that the primary risk factors for olfactory disorders of eCRSwNP were disease duration (P = 0.014) and alcohol intake (P = 0.012). Olfactory disorders were not associated with the disease course of eCRSwNP but were correlated with the disease duration of non-eCRSwNP (P = 0.008). When the clinical duration was less than 10 years, there was a significant difference in olfactory disorders between eCRSwNP and non-eCRSwNP groups (P < 0.01). However, when the clinical duration was over 10 years, the difference was not statistically significant (P = 0.264). The VAS score of olfactory disorders of over 5.75 could be used to predict the diagnosis of eCRSwNP (area under the curve ＝0.674, 95% confidence intervals: 0.559–0.689, P = 0.000). Conclusions: Olfactory disorder was the major nasal symptom that could be used to distinguish eCRSwNP and non-eCRSwNP. ECRSwNP patients were more prone to have olfactory dysfunction. Our findings suggested that evaluation of nasal symptoms would help diagnose eCRSwNP and determine subsequent clinical treatment strategies.

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