scholarly journals Primary Malignant Melanoma Limited to the External Auditory Canal: A Rare Presentation

2021 ◽  
Author(s):  
Dillip Kumar Samal ◽  
C. Preetam ◽  
Anjan Kumar Sahoo
Keyword(s):  
Malignant Melanoma ◽  
Local Excision ◽  
External Auditory Canal ◽  
Wide Local Excision ◽  
Poor Prognosis ◽  
Late Presentation ◽  
Rare Presentation ◽  
Slow Growing ◽  
Disease Free

AbstractMalignant melanoma limited to the external auditory canal is very rare. These patients present relatively late as compared with melanoma involving other subsites of external ear. However, the tumor is slow-growing but shows aggressive behavior with a poor prognosis when presented late. We have a 44-year-old female who presented with a blackish lesion, which was bleeding on and off from her left ear. She was managed with wide local excision, preserving maximum part of external auditory canal cartilage. The histopathology of the lesion was suggestive of malignant melanoma. After a thorough evaluation, she was kept under close follow-up. Malignant melanoma of external auditory canal shows poor prognosis usually, mainly because of late presentation. Thus, early diagnosis is crucial, as in our case, where wide local excision was sufficing, and the patient is disease-free after 4 years of follow-up.

scholarly journals Verrucous Carcinoma of the Vulva

2021 ◽  
Vol 107 (1_suppl) ◽  
pp. 8-8
Author(s):  
DP Agbanglanon ◽  
S Jaba ◽  
GG Kietga ◽  
I M’barki ◽  
H Elkacemi ◽  
...  
Keyword(s):  
Lymph Node ◽  
Local Excision ◽  
Wide Local Excision ◽  
Verrucous Carcinoma ◽  
Distinct Type ◽  
Lymph Node Involvement ◽  
Disease Stage ◽  
Concurrent Radiochemotherapy ◽  
Slow Growing

Introduction: Vulvar verrucous carcinoma (VC) is extremely rare, accounting for less than 1% of vulvar cancer cases. Effectively, it is characterization by a slow growing, no metastasis or lymph node involvement. The aim of this study was to report our experience with this disease Material and Methods: This is a retrospective study of patients with vulvar VC who were treated at National Institute of Oncology between 2013 and 2018. Clinicopathological characteristics, treatment and follow-up were extracted from the medical records. Results: Three cases were identified in the National Institut of Oncology. The average age at diagnosis was 66 years (± 10.02). The average time from the onset of symptoms to diagnosis was 17 months (± 12,7). All patients complained of a vulvar mass or nodule, accompanied by vulvar pruritus and/or pain, which was the reason for consultation. A preliminary pathological diagnosis of squamous cell carcinoma was made in two cases. Surgical treatment included wide local excision, radical vulvectomy with lymph node dissection in the groin. Tumor size and invasion depth ranged from 50 to 105 mm and 17 to 35 mm respectively. In the final histology, VC of the vulva staged IB (2 cases) and staged III (1 case) with marginal limits in two cases. The concurrent radiochemotherapy was performed in one case, exclusive radiotherapy in one case and only surgery in one case. Regarding toxicity after concurrent radiochemotherapy and exclusive radiotherapy we had observed respectely grade 2 proctitis with renal toxicity and grade 2 radiodermatitis. The mean follow-up was 43 months with no recurrence in all cases. The prognosis is good, with low recurrent rate if wide local excision is performed. Conclusions: Vulvar VC is a distinct type of slow-growing, tumor with unclear etiology. Surgery is the most effective treatment. Concurrent radiochemotherapy indicated depending on disease stage and risk factors.

scholarly journals A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Ikuma Nozaki ◽  
Yumi Tone ◽  
Junko Yamanaka ◽  
Hideko Uryu ◽  
Yuko Shimizu-Motohashi ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Malignant Transformation ◽  
Poor Prognosis ◽  
Mediastinal Mass ◽  
Bone Biopsy ◽  
Systematic Evaluation ◽  
Anterior Mediastinal Mass ◽  
Malignant Teratoma ◽  
Experienced Pain

We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.

scholarly journals Extensive Ameloblastic Fibroma in an Adolescent Patient: A Case Report with a Follow-Up of 4 Years

2009 ◽  
Vol 03 (03) ◽  
pp. 224-228 ◽  
Author(s):  
Poramate Pitak-Arnnop ◽  
André Chaine ◽  
Kittipong Dhanuthai ◽  
Jacques-Charles Bertrand ◽  
Chloé Bertolus
Keyword(s):  
Treatment Approach ◽  
Adolescent Patient ◽  
Odontogenic Tumour ◽  
Posterior Portion ◽  
Initial Surgery ◽  
Ameloblastic Fibroma ◽  
The Common ◽  
Slow Growing ◽  
Disease Free

ABSTRACTAmeloblastic fibroma (AF) is a rare odontogenic tumour of the jaw which usually occurs in the first 2 decades of life. The common clinical manifestation is a slow-growing swelling. We report a case of a 16-year-old male patient presenting with extensive AF of the mandible. He underwent a conservative enucleation. The tumour recurred 2 years after the initial surgery, requiring the second enucleation.The patient has continued to be followed closely and has been disease-free for 4 years. Recent evidence suggests that the recurrent rate of AF is relatively high, and malignant transformation of AF may occur after recurrences or multiple surgeries. A conservative treatment approach with close surveillance is recommended. Anatomical limitations should be taken into account, especially when enucleation of AF in the posterior portion of the jaw is performed. Current surgical pathologic issues of the tumour are also discussed. (Eur J Dent 2009;3:224-228)

Comparison of Outcomes for Malignant Melanoma of the Face Treated Using Mohs Micrographic Surgery and Wide Local Excision

2013 ◽  
Vol 39 (11) ◽  
pp. 1637-1645 ◽  
Author(s):  
Laura Chin-Lenn ◽  
Tania Murynka ◽  
Gregory J. McKinnon ◽  
John P. Arlette
Keyword(s):  
Malignant Melanoma ◽  
Local Excision ◽  
Wide Local Excision ◽  
Mohs Micrographic Surgery ◽  
Micrographic Surgery ◽  
The Face

Laryngeal Verrucous Carcinoma: A Systematic Review

2016 ◽  
Vol 156 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Kristen A. Echanique ◽  
Stuti V. Desai ◽  
Emily Marchiano ◽  
Eleonora F. Spinazzi ◽  
Primož Strojan ◽  
...  
Keyword(s):  
Local Excision ◽  
Verrucous Carcinoma ◽  
Treatment Protocol ◽  
Disease Free Survival ◽  
Treatment Modalities ◽  
Definitive Treatment ◽  
T Stage ◽  
Number Of Patients ◽  
Disease Free

Objective Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of ongoing conversation, and no definitive treatment protocol based on T stage and presentation exists. This review examines characteristics, treatment modalities, and patient outcomes of LVC. Data Sources PubMed, MEDLINE, EMBASE, and Web of Science. Methods Databases were searched through October 29, 2015, for literature detailing individual patient cases of LVC. Variables analyzed included patient demographics, tumor characteristics, tumor size, treatment, and outcomes. Results Thirty-seven articles with 369 cases were included. LVC was found more commonly in males (13.8:1), at an average age of 58.7 years, and located in the glottis (74.0%). Most patients had local disease at presentation (94.9%). The most common presenting symptom was hoarseness (92.3%). The most common primary treatment was surgery alone (72.3%), with local excision as the most common technique (56.8%). In patients with data available on both surgical modality and T stage, most patients who presented as T1 and were managed surgically underwent local excision (79.2%). Surgical treatment alone led to high rates of disease-free survival at follow-up (86.8%). A large number of patients presenting with T1 disease were disease free at follow-up (88.6%). Overall survival was 80.3%. Conclusion LVC is most often managed surgically. The extent of surgical resection may be guided by T stage, with smaller tumors resected via local excision and larger tumors via partial or total laryngectomy. Regardless of T stage or therapy, LVC has a good posttreatment prognosis.

Hemangiopericytoma of meningo-fronto-naso-orbito-maxillary complex

2020 ◽  
Vol 13 (10) ◽  
pp. e239135
Author(s):  
Bhavuk Vanza ◽  
Anshul Rai ◽  
Neha Khare ◽  
HS Verma
Keyword(s):  
Oral Cavity ◽  
Local Excision ◽  
Wide Local Excision ◽  
Good Option ◽  
Maxillary Artery ◽  
Vascular Tumour ◽  
Female Predominance ◽  
Feeder Vessel

Hemangiopericytoma (HPC) is a rare vascular tumour and difficult to diagnose clinically. Incidence is reported in fourth to fifth decade of life.With female predominance, 3%–5% cases affect the oral cavity, sinus lining and meninges. The patient presented with 8×6 cm swelling on her face, evaluation reported it to be HPC. Bilateral maxillary artery embolisation, wide local excision of the lesion, preserving the left eye and its function, was done. No recurrence is reported at 1-year follow-up. Response of such lesions to radiotherapy is questionable; with no lymphadenopathy and adequate encapsulation, embolisation of feeder vessel followed by a wide local excision of the lesion seems to be a fairly good option of treatment.

scholarly journals Surgical Treatment of a Patient with a Solitary Thyroid Metastasis from Primary Sigmoid Adenocarcinoma: A Case Report and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Kohei Yamahara ◽  
Toshiaki Moriki ◽  
Yuki Katsura ◽  
Kana Lee ◽  
Satoshi Ikegami
Keyword(s):  
Poor Prognosis ◽  
Delayed Diagnosis ◽  
Disease Free Survival ◽  
Thyroid Metastasis ◽  
Free Survival ◽  
Low Threshold ◽  
Solitary Liver ◽  
Disease Free ◽  
Sigmoid Cancer

Malignant metastases to the thyroid are rare and even rarer from colorectal cancer (CRC). Most cases of CRC metastasis to the thyroid involve metastases to other organs as well, particularly the liver and/or lung. There are only three reports of CRC metastasizing to the thyroid without involvement of another site. Patients with solitary thyroid metastasis from CRC have a poor prognosis after surgery, whereas resection is beneficial in their counterparts with a solitary liver or lung metastasis. This difference could be the result of delayed diagnosis of thyroid metastasis in patients with CRC, given that postoperative follow-up examination of the thyroid is not routinely performed. Here we describe a patient who was found to have a solitary metastasis of sigmoid cancer to the thyroid on postoperative imaging and has had prolonged disease-free survival after thyroidectomy. Our experience suggests that a low threshold of suspicion is crucial for timely diagnosis of thyroid metastasis from CRC and that resection can improve disease-free survival.

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