RSV-Schutzimpfung: Einfluss auf Asthma und Wheezing

2017 ◽  
Vol 221 (02) ◽  
pp. 58-58

Mochizuki H et al. Pavlizumab prophylaxis in preterm infants and subsequent recurrent wheezing: 6 Year Follow up Study. AJRCCM 2017; DOI: 10.1164/rccm.201609-1812OC Infektionen mit dem respiratorischen Syncitial-Virus (RSV) sind bei Risikokindern mit einem späteren intermittierendem Wheezing und Asthma bronchiale assoziiert. Die passive Immunisierung mit Palivizumab beugte bei Frühgeborenen einem intermittierenden Wheezing im ersten Lebensjahr vor. Kindliches Asthma entwickelt sich aber erst im Kleinkindalter. Die prospektive Beobachtungsstudie zeigt die Effekte der Impfung auf Asthma und Wheezing bis zum 6. Lebensjahr.

2017 ◽  
Vol 196 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Hiroyuki Mochizuki ◽  
Satoshi Kusuda ◽  
Kenji Okada ◽  
Shigemi Yoshihara ◽  
Hiroyuki Furuya ◽  
...  

2013 ◽  
Vol 142 (7) ◽  
pp. 1362-1374 ◽  
Author(s):  
B. FAUROUX ◽  
J.-B. GOUYON ◽  
J.-C. ROZE ◽  
C. GUILLERMET-FROMENTIN ◽  
I. GLORIEUX ◽  
...  

SUMMARYThe aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39–41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71–13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.


2016 ◽  
Vol 26 (5) ◽  
pp. 1349-1360 ◽  
Author(s):  
M. R. S. Moura ◽  
C. G. A. Araújo ◽  
M. M. Prado ◽  
H. B. M. S. Paro ◽  
R. M. C. Pinto ◽  
...  

2010 ◽  
Vol 95 (11) ◽  
pp. 4898-4908 ◽  
Author(s):  
Caroline Delahunty ◽  
Shona Falconer ◽  
Robert Hume ◽  
Lesley Jackson ◽  
Paula Midgley ◽  
...  

Context: Transient hypothyroxinemia is the commonest thyroid dysfunction of premature infants, and recent studies have found adverse associations with neurodevelopment. The validity of these associations is unclear because the studies adjusted for a differing range of factors likely to influence neurodevelopment. Objective: The aim was to describe the association of transient hypothyroxinemia with neurodevelopment at 5.5 yr corrected age. Design: We conducted a follow-up study of a cohort of infants born in Scotland from 1999 to 2001 ≤34 wk gestation. Main Outcome Measures: We measured scores on the McCarthy scale adjusted for 26 influences of neurodevelopment including parental intellect, home environment, breast or formula fed, growth retardation, and use of postnatal drugs. Results: A total of 442 infants ≤34 wk gestation who had serum T4 measurements on postnatal d 7, 14, or 28 and 100 term infants who had serum T4 measured in cord blood were followed up at 5.5 yr. Infants with hypothyroxinemia (T4 level ≤ 10th percentile on d 7, 14, or 28 corrected for gestational age) scored significantly lower than euthyroid infants (T4 level greater than the 10th percentile and less than the 90th percentile on all days) on all McCarthy scales, except the quantitative. After adjustment for confounders of neurodevelopment, hypothyroxinemic infants scored significantly lower than euthyroid infants on the general cognitive and verbal scales. Conclusions: Our findings do not support the view that the hypothyroxinemic state, in the context of this analysis, is harmless in preterm infants. Many factors contribute both to the etiology of hypothyroxinemia and neurodevelopment; strategies for correction of hypothyroxinemia should acknowledge its complex etiology and not rely solely on one approach.


2008 ◽  
Vol 84 (10) ◽  
pp. 667-671 ◽  
Author(s):  
Claudio De Felice ◽  
Bruno De Capua ◽  
Daniele Costantini ◽  
Carla Martufi ◽  
Paolo Toti ◽  
...  

2013 ◽  
Vol 45 (01) ◽  
pp. 022-029 ◽  
Author(s):  
Natalie LeCouffe ◽  
Elisabeth Westerbeek ◽  
Petra van Schie ◽  
Veronique Schaaf ◽  
Harrie Lafeber ◽  
...  

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