Gelenkbeteiligung bei Akromegalie

ZusammenfassungDie Akromegalie ist eine seltene Erkrankung, welche in den meisten Fällen aus einer hypophysären Überproduktion von Wachstumshormon (GH – Growth Hormone) resultiert. Der in der Folge anhaltende IGF-1(Insulin like Growth Factor-1)-Exzess bewirkt zahlreiche morphologische und metabolische Veränderungen des Organismus inklusive Organomegalie, arterieller Hypertonie und Diabetes mellitus. Insbesondere die kardiovaskuläre Morbidität nimmt zu, diese ist auch hauptverantwortlich für vermehrte Sterblichkeit der Betroffenen. Wiewohl nicht prognoseentscheidend, manifestiert sich die Erkrankung gleichfalls am Bewegungsapparat. Drei Komplikationen sind relevant: eine Arthropathie größerer Gelenke, lumbale Wirbelsäulenveränderungen sowie das Karpaltunnelsyndrom. Die Behandlung dieser Komplikationen unterscheidet sich nicht von der Therapie anderer Krankheitsmanifestationen: entscheidend ist die Beseitigung des GH-/IGF-1-Exzesses. Je früher die Diagnose gestellt und die Behandlung eingeleitet wird, desto besser ist die Prognose, sind doch ossäre/artikuläre Veränderungen in vielen Fällen irreversibel.

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Growth Hormone Insulin-Like Growth Factor I Axis in Insulin-Dependent Diabetes mellitus

Hormone Research ◽

10.1159/000184969 ◽

1996 ◽

Vol 46 (1) ◽

pp. 2-6 ◽

Cited By ~ 22

Author(s):

D.B. Dunger ◽

T.D. Cheetham

Keyword(s):

Diabetes Mellitus ◽

Growth Hormone ◽

Growth Factor ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Insulin Like Growth Factor ◽

Factor I ◽

Insulin Dependent ◽

Growth Factor I

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Growth Hormone Secretion, Serum, and Cerebral Spinal Fluid Insulin and Insulin-Like Growth Factor-l Concentrations in Pigs with Streptozotocin-Induced Diabetes Mellitus

Experimental Biology and Medicine ◽

10.3181/00379727-201-43503 ◽

1992 ◽

Vol 201 (2) ◽

pp. 223-228 ◽

Cited By ~ 9

Author(s):

C. R. Barb ◽

N. M. Cox ◽

C. A. Carlton ◽

W. J. Chang ◽

R. F. Randle

Keyword(s):

Diabetes Mellitus ◽

Growth Hormone ◽

Growth Factor ◽

Cerebral Spinal Fluid ◽

Hormone Secretion ◽

Growth Hormone Secretion ◽

Spinal Fluid ◽

Insulin Like Growth Factor ◽

Streptozotocin Induced Diabetes

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Insulin-Like Growth Factor 1 and Growth Hormone Levels in Patients with Type 1 Diabetes mellitus

Growth Factors of the Vascular and Nervous Systems ◽

10.1159/000420898 ◽

2015 ◽

pp. 115-122 ◽

Cited By ~ 1

Author(s):

Andrea Giustina ◽

Giuseppina Ruggeri ◽

Corrado Bodini ◽

Simonetta Bossoni ◽

Angela Girelli ◽

...

Keyword(s):

Diabetes Mellitus ◽

Growth Hormone ◽

Type 1 Diabetes ◽

Growth Factor ◽

Type 1 Diabetes Mellitus ◽

Insulin Like Growth Factor ◽

Hormone Levels

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Alterations in the Growth Hormone-Insulin-Like Growth Factor Axis in Insulin Dependent Diabetes Mellitus

Hormone and Metabolic Research ◽

10.1055/s-2007-978716 ◽

1999 ◽

Vol 31 (02/03) ◽

pp. 172-181 ◽

Cited By ~ 94

Author(s):

A. Bereket ◽

C. Lang ◽

T. Wilson

Keyword(s):

Diabetes Mellitus ◽

Growth Hormone ◽

Growth Factor ◽

Insulin Dependent Diabetes Mellitus ◽

Insulin Dependent Diabetes ◽

Dependent Diabetes Mellitus ◽

Insulin Like Growth Factor ◽

Insulin Dependent

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Measurements of growth hormone and insulin-like growth factor 1 in cats with diabetes mellitus

Veterinary Record ◽

10.1136/vr.158.6.195 ◽

2006 ◽

Vol 158 (6) ◽

pp. 195-200 ◽

Cited By ~ 27

Author(s):

C. E. Reusch ◽

S. Kley ◽

M. Casella ◽

R. W. Nelson ◽

J. Mol ◽

...

Keyword(s):

Diabetes Mellitus ◽

Growth Hormone ◽

Growth Factor ◽

Insulin Like Growth Factor

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EFFECT of Aloe vera EXTRACT TO THE INSULIN-LIKE GROWTH FACTOR-1 (IGF-1) LEVELS FROM VISCERAL FAT TISSUE IN Rattus norvegicus WISTAR DIABETES MELLITUS

KnE Life Sciences ◽

10.18502/kls.v2i1.138 ◽

2015 ◽

Vol 2 (1) ◽

pp. 174

Author(s):

Lulut Dwi Nurmamulyosari ◽

Muhammad Rifqi Hariri ◽

Abdul Gofur ◽

Dwi Listyorini ◽

Hendra Susanto ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Growth Hormone ◽

Growth Factor ◽

Visceral Fat ◽

Rattus Norvegicus ◽

Aloe Vera ◽

Insulin Like Growth Factor ◽

Fat Tissue ◽

C 30

Diabetes mellitus is a metabolic disorder indicated by hyperglycaemia due to lack of insulin production, insulin activity, or both. It causes oxidative stress that may damage the receptor of Growth Hormone Releasing Hormone (GHRH) in the pituitary. As the result, Growth Hormone (GH) and Insulin-like Growth Factor-1 (IGF1) production are decreased and glucose uptakes to the cell is inhibited. Aloe vera has a high antioxidant activity. It is possible to counter oxidative stress in unregulated the production of IGF-1. This study aimed to determine the effect of A. vera extracts to the level of IGF-1 from visceral fat tissue Rattus norvegicus wistar diabetes mellitus. This study used 24 R. norvegicus wistar male. R. norvegicus STZ-induced diabetes mellitus R. norvegicus were grouped into positive control (C+), 30 mg/day, 60 mg/day, 120 mg/day. Fasting blood glucose test was performed to determine the successful induction of diabetes mellitus (DM) three days after induced. Non-DM rats (NDM) were grouped into negative control (C-), 30 mg/day, 60 mg/day, and 120 mg/ day. Each group was consisting of three replications. Each animal, except the controls, were treated 3 ml suspension of A. vera extract for 14 days by gavage. IGF-1 levels were measured using indirect ELISA. The result showed that the extract of A. vera significantly influenced the IGF-1 levels in DM group. The dose of 60 and 120 mg/day significantly raised the level of IGF-1 compared to C+. In NDM group the dose of 60 mg/ day significantly raised the level of IGF-1 compared to C-. Keywords: Aloe vera, Rattus norvegicus, IGF-1, visceral fat, diabetes mellitus

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Common insulin-like growth factor 1 (IGF-1) gene polymorphisms are not associated with the growth hormone (GH)-dose in adults with GH-deficiency

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0028-1096362 ◽

2008 ◽

Vol 116 (09) ◽

Author(s):

S Meyer ◽

U Köhler ◽

U Plöckinger ◽

GK Stalla ◽

U Tuschy ◽

...

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Gene Polymorphisms ◽

Gh Deficiency ◽

Insulin Like Growth Factor

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Cumulative effects of growth hormone and insulin-like growth factor-1 exposure on cardiovascular, cerebrovascular and metabolic co-morbidities in acromegaly patients

Endocrine Abstracts ◽

10.1530/endoabs.56.gp12 ◽

2018 ◽

Author(s):

Khyatisha Seejore ◽

Nikolaos Kyriakakis ◽

Marilena Giannoudi ◽

Julie Lynch ◽

Steve M Orme ◽

...

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Cumulative Effects ◽

Insulin Like Growth Factor

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Consensus on the change of criteria for cure of acromegaly during the last decade

Orvosi Hetilap ◽

10.1556/oh.2011.29092 ◽

2011 ◽

Vol 152 (18) ◽

pp. 703-708 ◽

Cited By ~ 1

Author(s):

Gábor László Kovács ◽

Judit Dénes ◽

Erika Hubina ◽

László Kovács ◽

Sándor Czirják ◽

...

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Disease Control ◽

Short Communication ◽

Consensus Statement ◽

Diagnosis And Treatment ◽

Clinical Aspects ◽

Insulin Like Growth Factor ◽

Criteria For Diagnosis ◽

Definition Of

The Acromegaly Consensus Group redefined the consensus criteria for cure of acromegaly. 74 neurosurgeons and experienced endocrinologists summarized the latest results on diagnosis and treatment of acromegaly. In this consensus statement the reliable growth hormone and insulin-like growth factor-1 assays were established. Definition of disease control was discussed based on the available publications and evidence. This short communication summarizes the clinical aspects of consensus criteria for diagnosis and cure of acromegaly based on the original article. Orv. Hetil., 2011, 152, 703–708.

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