The significance of non-REM sleep for memory processes in elderly subjects

2004 ◽  
Vol 36 (05) ◽  
Author(s):  
N Albrecht ◽  
OP Hornung ◽  
F Regen ◽  
H Danker-Hopfe ◽  
M Schreqdl ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Elderly Subjects ◽  
Memory Processes

Cortisol Enhances non-REM Sleep and Growth Hormone Secretion in Elderly Subjects

1997 ◽  
Vol 18 (4) ◽  
pp. 423-429 ◽  
Author(s):  
S Bohlhalter ◽  
H Murck ◽  
F Holsboer ◽  
A Steiger
Keyword(s):  
Growth Hormone ◽  
Rem Sleep ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Elderly Subjects

Memory Processes Involved in Morning Recall of Mental Rem-Sleep Experience: A Psycholinguistic Study

1981 ◽  
Vol 52 (2) ◽  
pp. 391-406 ◽  
Author(s):  
C. Cipolli ◽  
P. Salzarulo ◽  
A. Calabrese
Keyword(s):  
Rem Sleep ◽  
Linguistic Analysis ◽  
Morning Report ◽  
Physiological Variable ◽  
Syntactic Structures ◽  
Memory Processes ◽  
Night Awakening

For two nights 10 subjects were asked to recall their mental sleep experience after experimental awakening during REM sleep (night report) and again upon spontaneous morning awakening (morning report). The two types of report were subjected to linguistic analysis and compared. The number of sentences used to describe the mental sleep experience, their syntactic structures, and over-all report length were similar. Those contents common to both reports were in both cases encoded in about one fourth of the sleep-related kernel sentences, these kernel sentences being distributed over about two-thirds of the sentences of the report, generally the longer ones. The organization of the morning reports reflects the consolidation of the contents in memory. The only significant physiological variable, waking time, was negatively correlated to the numbers of kernel sentences and sentences reproducing contents previously encoded in the night reports. The organization of the morning report primarily appears to be the result of retrieval and encoding procedures relative to the mental sleep experience preceding the night awakening rather than simply to the encoded contents of the night report.

Speculations in “Temporal Delays in Incorporation of Events into Dreams”: A Reply to Roll

1996 ◽  
Vol 82 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Russell A. Powell ◽  
Tore A. Nielsen
Keyword(s):  
Rem Sleep ◽  
Animal Research ◽  
Psychological Explanation ◽  
Repetition Compulsion ◽  
Memory Processes ◽  
Lag Effect ◽  
Adaptation Model

Previously we pointed out similarities between patterns of delayed incorporations of daytime stimuli into dreams and delayed memory processes in rats. In commenting upon this article, Roll argued that this reductionistic leap is unwarranted. We contend that it would be remiss not to make note of this potential connection, especially in view of recent major contributions of animal research to the understanding of REM sleep and dreams. We also suggest that the disruption-avoidance-adaptation model constitutes a preferable psychological explanation for the dream-lag effect than Roll's psychoanalytic model of repression and repetition compulsion.

049 The Effect of Obstructive Sleep Apnea on Emotional Memory Consolidation

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A21-A21
Author(s):  
Tony Cunningham ◽  
Divya Kishore ◽  
Mengshuang Guo ◽  
Moroke Igue ◽  
Atul Malhotra ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Rem Sleep ◽  
Research Training ◽  
Emotional Memory ◽  
Sleep Medicine ◽  
Long Term Memory ◽  
Memory Processes ◽  
Specific Recognition ◽  
Obstructive Sleep

Abstract Introduction A growing body of evidence suggests that sleep is critical for the processing and consolidation of emotional information into long-term memory. Previous research has indicated that emotional components of scenes particularly benefit from sleep in healthy groups, yet sleep dependent emotional memory processes remain unexplored in many clinical cohorts, including those with obstructive sleep apnea (OSA). Methods In this study, a group of newly diagnosed OSA patients (n=26) and a matched group of healthy controls (n=24) encoded scenes with negative or neutral foreground objects placed on neutral backgrounds prior to a night of polysomnographically recorded sleep. In the morning, they completed a recognition test in which objects and backgrounds were presented separately and one at a time. Results OSA patients have a deficit in both overall gist memory and the specific recognition memory for the scenes. Impairment of gist recognition was across all elements of the scenes, both negative and neutral objects and backgrounds [main effect of group: F(1,48) = 13.5, p=0.001], while specific recognition impairment was exclusively found for negative objects [t(48)=2.0, p=0.05]. Across all participants, successful gist recognition correlated positively with sleep efficiency (p=0.001) and REM sleep (p=0.009), while successful specific memory recognition correlated only with REM sleep (p=0.004). Conclusion Our findings indicate that fragmented sleep and reduced REM sleep, both hallmarks of OSA, significantly disrupt distinct memory processes for emotional content. Gist memory is universally impacted, while memory for specific details appears to have a greater deterioration for negative aspects of memories. These memory affects may have impacts on complex emotional processes, such as emotion regulation, and could contribute to the high comorbid depressive symptoms in OSA. Support (if any) The authors would like to thank the funding sources awarded to author ID for supporting this research: NIH grant # K23HL103850 and American Sleep Medicine Foundation grant #54-JF-10. Author TJC is currently funded by the Research Training Program in Sleep, Circadian and Respiratory Neurobiology (NIH T32 HL007901) through the Division of Sleep Medicine at Harvard Medical School and Brigham & Women’s Hospital.

scholarly journals Rare Case of Late-Onset Narcolepsy Type 1

2020 ◽  
Vol 12 (3) ◽  
pp. 428-432
Author(s):  
Petra Kovalská ◽  
Simona Dostálová ◽  
Hana Machová ◽  
Petra Nytrová ◽  
Eszter Maurovich Horvat ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Daytime Sleepiness ◽  
Sleep Latency ◽  
Sleep Onset ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Elderly Subjects ◽  
Apnea Hypopnea Index ◽  
Sleep Behavior

A 69-year-old male developed symptoms typical of the diagnosis of narcolepsy type 1 without any previous triggering events. First, daytime sleepiness occurred, soon followed by cataplexy. Nocturnal polysomnography revealed rapid eye movement (REM) sleep behavior disorder, a apnea-hypopnea index of 25.8 events/h, and no sleep-onset REM. Multiple Sleep Latency Test showed a mean sleep latency of 2.1 min and REM sleep in 3 tests. HLA DQB1*06:02 was positive and hypocretin-1 in cerebrospinal fluid unmeasurable. A treatment with 50 mg clomipramine controlled the cataplexy; excessive daytime sleepiness was sufficiently managed by repeated naps. The administration of 0.25 mg of clonazepam subjectively improved REM sleep behavior disorder. Bilevel Positive Airway Pressure improved the apnea-hypopnea index without important influence on sleepiness. Our unique case demonstrates that even elderly subjects can develop narcolepsy type 1.

P4-136: Parkinsonism is associated with probable REM sleep behavior disorder in cognitively normal elderly subjects: The Mayo Clinic Study of Aging

2008 ◽  
Vol 4 ◽  
pp. T710-T710
Author(s):  
Nur E. Mihci ◽  
Jennifer R. Molano ◽  
Bradley Boeve ◽  
Rosebud O. Roberts ◽  
Yonas E. Geda ◽  
...  
Keyword(s):  
Rem Sleep ◽  
Mayo Clinic ◽  
Rem Sleep Behavior Disorder ◽  
Behavior Disorder ◽  
Elderly Subjects ◽  
Sleep Behavior ◽  
Cognitively Normal ◽  
Clinic Study

Age Differences in Memory Scanning?

1982 ◽  
Vol 55 (2) ◽  
pp. 499-504
Author(s):  
Lynd D. Bacon ◽  
Robert S. Wilson ◽  
Alfred W. Kaszniak
Keyword(s):  
Age Differences ◽  
Aging Process ◽  
Scanning Speed ◽  
Primary Memory ◽  
Elderly Subjects ◽  
Memory Scanning ◽  
Memory Processes

One conclusion from the literature on age differences in memory has been that primary memory processes are unaffected by advancing age. An exception to this generalization is the finding that material in primary memory is scanned more slowly with advancing age. Previous studies of this phenomenon, however, have yielded inconsistent results. In the present study we compared memory scanning rates of 12 young and 12 elderly subjects. There were no age differences in scanning speed or accuracy. The results support Craik's 1977 contention that primary memory processes are relatively unaffected by the aging process.

Effect of the GABAA agonist gaboxadol on nocturnal sleep and hormone secretion in healthy elderly subjects

2001 ◽  
Vol 281 (1) ◽  
pp. E130-E137 ◽  
Author(s):  
Marike Lancel ◽  
Thomas C. Wetter ◽  
Axel Steiger ◽  
Stefan Mathias
Keyword(s):  
Rem Sleep ◽  
Hormone Secretion ◽  
Low Frequency ◽  
Sleep Efficiency ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Nocturnal Sleep ◽  
Endocrine Activity ◽  
Healthy Elderly ◽  
Healthy Elderly Subjects

Aging is associated with a dramatic decrease in sleep intensity and continuity. The selective GABAA receptor agonist gaboxadol has been shown to increase non-REM sleep and the duration of the non-REM episodes in rats and sleep efficiency in young subjects and to enhance low-frequency activity in the electroencephalogram (EEG) within non-REM sleep in both rats and humans. In this double-blind, placebo-controlled study, we investigated the influence of an oral dose of 15 mg of gaboxadol on nocturnal sleep and hormone secretion (ACTH, cortisol, prolactin, growth hormone) in 10 healthy elderly subjects (6 women). Compared with placebo, gaboxadol did not affect endocrine activity but significantly reduced perceived sleep latency, elevated self-estimated total sleep time, and increased sleep efficiency by decreasing intermittent wakefulness and powerfully augmented low-frequency activity in the EEG within non-REM sleep. These findings indicate that gaboxadol is able to increase sleep consolidation and non-REM sleep intensity, without disrupting REM sleep, in elderly individuals and that these effects are not mediated by a modulation of hormone secretion.

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