scholarly journals Recent Advances in Computational Methods in Engineering Mechanics

2021 ◽  
Vol 147 (12) ◽  
pp. 02021001
Author(s):  
Haim Waisman ◽  
Ertugrul Taciroglu
2019 ◽  
Vol 20 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Wen Zhang ◽  
Weiran Lin ◽  
Ding Zhang ◽  
Siman Wang ◽  
Jingwen Shi ◽  
...  

Background:The identification of drug-target interactions is a crucial issue in drug discovery. In recent years, researchers have made great efforts on the drug-target interaction predictions, and developed databases, software and computational methods.Results:In the paper, we review the recent advances in machine learning-based drug-target interaction prediction. First, we briefly introduce the datasets and data, and summarize features for drugs and targets which can be extracted from different data. Since drug-drug similarity and target-target similarity are important for many machine learning prediction models, we introduce how to calculate similarities based on data or features. Different machine learningbased drug-target interaction prediction methods can be proposed by using different features or information. Thus, we summarize, analyze and compare different machine learning-based prediction methods.Conclusion:This study provides the guide to the development of computational methods for the drug-target interaction prediction.


2012 ◽  
Vol 9 (3) ◽  
pp. 143-159
Author(s):  
Vasiliki Spyropoulou ◽  
Maria Anna Rapsomaniki ◽  
Konstantinos Theofilatos ◽  
Stergios Papadimitriou ◽  
Spiros Likothanassis ◽  
...  

Author(s):  
Carolyn Parkinson

Abstract Recent years have seen a surge of exciting developments in the computational tools available to social neuroscientists. This paper highlights and synthesizes recent advances that have been enabled by the application of such tools, as well as methodological innovations likely to be of interest and utility to social neuroscientists, but that have been concentrated in other sub-fields. Papers in this special issue are emphasized, many of which contain instructive materials (e.g., tutorials, code) for researchers new to the highlighted methods. These include approaches for modeling social decisions, characterizing multivariate neural response patterns at varying spatial scales, using decoded neurofeedback to draw causal links between specific neural response patterns and psychological and behavioral phenomena, examining time-varying patterns of connectivity between brain regions, and characterizing the social networks in which social thought and behavior unfold in everyday life. By combining computational methods for characterizing participants’ rich social environments – at the levels of stimuli, paradigms, and the webs of social relationships that surround people – with those for capturing the psychological processes that undergird social behavior and the wealth of information contained in neuroimaging datasets, social neuroscientists can gain new insights into how people create, understand, and navigate their complex social worlds.


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