Time delay and noise explaining the behaviour of the cell growth in fermentation process

2015 ◽  
Author(s):  
Tawfiqullah Ayuobi ◽  
Norhayati Rosli ◽  
Arifah Bahar ◽  
Madihah Md Salleh
Keyword(s):  
Time Delay ◽  
Cell Growth ◽  
Fermentation Process

Effects of time delay on the dynamic of kinetic model of microbial fermentation process

2014 ◽  
Vol 55 ◽  
pp. 336
Author(s):  
Kasbawati ◽  
Agus Yodi Gunawan ◽  
Rukman Hertadi ◽  
Kuntjoro Adji Sidarto
Keyword(s):  
Time Delay ◽  
Kinetic Model ◽  
Fermentation Process ◽  
Microbial Fermentation

Optimizing the Fermentation Process for Recombinant Escherichia coli on Base of Metabolic Flux Analysis of Amino Acids

2012 ◽  
Vol 550-553 ◽  
pp. 1055-1059
Author(s):  
Tao Zhang ◽  
Yan E Luo ◽  
Dai Di Fan ◽  
Lei Guo ◽  
Ting Zhen Mu
Keyword(s):  
Amino Acids ◽  
Cell Growth ◽  
Metabolic Flux Analysis ◽  
Fermentation Process ◽  
Metabolic Flux ◽  
Biological Activities ◽  
Basic Unit ◽  
Flux Analysis ◽  
Protein Molecules ◽  
Affect Cell Growth

Amino acids, the basic unit of protein molecules, are closely related to some important biological activities and they affect cell growth and metabolism directly or indirectly. Previous studies showed that adding amino acids can improve the productivity of human-like collagen (HLC). Thus, we analyzed the amino acids metabolism during the fermentation process. The results of metabolic flux analysis of amino acids implied that the cell growth and production of HLC were active as long as the free amino acids in the medium were adequate. This suggested control the concentration of amino acids could improve cell growth and human-like collagen production.

scholarly journals Bioconversion of hydrolyzed cashew peduncle bagasse for ethanol and xylitol production

2017 ◽  
Vol 21 (7) ◽  
pp. 488-492 ◽  
Author(s):  
Lorena L. de Medeiros ◽  
Flávio L. H. da Silva ◽  
Sharline F. M. Santos ◽  
Marta S. Madruga ◽  
Débora J. N. de Melo ◽  
...  
Keyword(s):  
Cell Growth ◽  
Industrial Waste ◽  
Large Scale ◽  
Fermentation Process ◽  
Candida Guilliermondii ◽  
Anacardium Occidentale ◽  
Xylitol Production ◽  
Maximum Production ◽  
Maximum Cell ◽  
Scale 8

ABSTRACT The agro-industrial waste deposited in the environment causes problems in nature that can be solved with the use and generation of bioproducts. Thus, the objective was to study the lignocellulosic fraction of cashew (Anacardium occidentale L.) peduncle bagasse and fermentation on large scale (8-16 times) using the strain Candida guilliermondii CCT-3544 as production agent. According to the obtained results, it can be noted that the dry cashew peduncle bagasse has 21.45% of cellulose, 10.96% of hemicellulose and 35.39% of lignin. During fermentation, C. guilliermondii 3544-CAT was able to grow on medium containing hydrolysate, with maximum cell growth concentration of 3.5 g L-1. The behavior of the sugars in the fermentation process was similar in the different variables, with maximum production of ethanol and xylitol at 48 h of fermentation.

TUMOR CELL GROWTH SUBJECTED TO CORRELATED NOISES AND TIME DELAY

2016 ◽  
Vol 16 (02) ◽  
pp. 1650015
Author(s):  
Y. L. FENG ◽  
L. L. GAO ◽  
Y. F. LIU ◽  
M. ZHANG ◽  
J. M. DONG
Keyword(s):  
Time Delay ◽  
Cell Growth ◽  
Tumor Cell ◽  
Cell Population ◽  
First Passage Time ◽  
Planck Equation ◽  
Tumor Cell Growth ◽  
Tumor Cell Population ◽  
Correlation Strength ◽  
Correlated Noises

The tumor cell growth with time-delayed feedback driven by correlated noises under the immune surveillance are investigated within an anti-tumor model. The effects of the noise correlation strength and time delay on the stationary probability distribution, the average tumor cell population and the mean first passage time (MFPT) are analyzed in detail based on the delay Fokker–Planck equation. The effects of the correlation strength and time delay could play the same role in the average tumor cell population, but play opposite role in the MFPT. In addition, the role of the correlation strength and time delay for different activation thresholds of immune system is explored.

Mathematical Model of the Cell Growth for Methane-Oxidizing Bacteria

2015 ◽  
Vol 731 ◽  
pp. 345-348
Author(s):  
Jing Dong ◽  
He Teng Wang ◽  
Ying Xin Zhang
Keyword(s):  
Mathematical Modeling ◽  
Experimental Data ◽  
Mathematical Model ◽  
Cell Growth ◽  
Living Cell ◽  
Fermentation Process ◽  
Logistic Curve ◽  
Cell Content ◽  
Methane Oxidizing Bacteria

The dynamic trends of living cell content of methane-oxidizing bacteria during its fermentation process were analyzed. According to the experimental data, mathematical modeling of methane-oxidizing bacteria cell growth was simulated. The results showed that the logistic curve could be used to describe the mathematical modeling of methane-oxidizing bacteria cell growth well. The establishment of the model is the theoretic basis in optimizing the fermentable parameters and analyzing the fermented metabolites.

Stochastic resonance in a time-delayed tumor cell growth system driven by additive and multiplicative noises

2018 ◽  
Vol 32 (22) ◽  
pp. 1850259 ◽  
Author(s):  
Gang Zhang ◽  
Jiabei Shi ◽  
Tianqi Zhang
Keyword(s):  
Time Delay ◽  
Cell Growth ◽  
Tumor Cell ◽  
Stochastic Resonance ◽  
Additive Noise ◽  
State Theory ◽  
Periodic Signal ◽  
Tumor Cell Growth ◽  
System Parameters ◽  
Growth System

In this paper, the stochastic resonance (SR) phenomenon in a time-delayed tumor cell growth system subjected to a multiplicative periodic signal, the multiplicative and additive noise is investigated. By applying the small time-delay method and two-state theory, the expressions of the mean first-passage time (MFPT) and signal-to-noise ratio (SNR) are obtained, then, the impacts of time delay, noise intensities and system parameters on the MFPT and SNR are discussed. Simulation results show that the multiplicative and additive noise always weaken the SR effect; while time delay plays a key role in motivating the SR phenomenon when noise intensities take a small value, it will restrain SR phenomenon when noise intensities take a large value; the cycle radiation amplitude always plays a positive role in stimulating the SR phenomenon, while, system parameters play different roles in motivating or suppressing SR under the different conditions of noise intensities.

Increasing CoQ10 Production by Rhodopseudomonas palustris J001 Using a Two-Stage Fermentation Process

2008 ◽  
Vol 63 (11-12) ◽  
pp. 884-888
Author(s):  
Shi-yun Jiang ◽  
Long-jiang Yu
Keyword(s):  
Cell Growth ◽  
Fermentation Process ◽  
Switching Time ◽  
Rhodopseudomonas Palustris ◽  
Food Supplement ◽  
Two Stage ◽  
Successful Approach ◽  
Stage Process ◽  
The One ◽  
Coq10 Production

Abstract CoQ10 is used not only as a medicine but also as a food supplement due to its various physiological activities. The production of CoQ10 by microbes is a successful approach for generating large amounts of this natural product. The effects of dissolved oxygen (DO) contents and the two-stage fermentation process on cell growth and CoQ10 production by Rhodopseudomonas palustris J001 were investigated. The optimal DO contents for cell growth and CoQ10 production were 45% and 15%, respectively. A two-stage fermentation process, which consists of a 1st stage with 45% DO, a 2nd stage with 15% DO and a synchronous feeding of 2.0% NaAc at the switching time (42 h after inoculation), has proven to be the optimum fermentation process for the production of CoQ10. The maximum biomass, CoQ10 production and CoQ10 production rate were 1.31 g l-1, 89.1 mg l-1, and 1.142 mg l-1 h-1, respectively, increased by 28%, 585% and 426% as compared to the one-stage batch production with 45% DO. The DO level was the major factor to increase the CoQ10 production by the two-stage process.

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