Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice

2000 ◽  
Vol 106 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Mayumi Kotani ◽  
Motonobu Matsumoto ◽  
Akihito Fujita ◽  
Shinji Higa ◽  
Way Wang ◽  
...  
Keyword(s):  
Leaf Extract ◽  
Persimmon Leaf Extract ◽  
Persimmon Leaf

scholarly journals Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes

2015 ◽  
Vol 12 (2) ◽  
pp. 2547-2554 ◽  
Author(s):  
UI-JIN BAE ◽  
SOO-HYUN PARK ◽  
SU-YOUNG JUNG ◽  
BYUNG-HYUN PARK ◽  
SOO-WAN CHAE
Keyword(s):  
Murine Model ◽  
Leaf Extract ◽  
Persimmon Leaf Extract ◽  
Persimmon Leaf

scholarly journals Enhanced biological activities of gamma-irradiated persimmon leaf extract

2017 ◽  
Vol 58 (5) ◽  
pp. 647-653 ◽  
Author(s):  
Byoung-Ok Cho ◽  
Denis Nchang Che ◽  
Hong-Hua Yin ◽  
Seon-Il Jang
Keyword(s):  
Gamma Irradiation ◽  
Leaf Extract ◽  
Total Flavonoid ◽  
Total Polyphenol ◽  
Raw264.7 Macrophages ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Gamma Irradiated ◽  
Persimmon Leaf Extract ◽  
Persimmon Leaf

Abstract The aim of this study was to compare the anti-oxidative and anti-inflammatory activities of gamma-irradiated persimmon leaf extract (GPLE) with those of non-irradiated persimmon leaf extract (PLE). Ethanolic extract of persimmon leaf was exposed to gamma irradiation at a dose of 10 kGy. After gamma irradiation, the color of the extract changed from dark brown to light brown. The anti-oxidative and anti-inflammatory activities of GPLE and PLE were assessed from: total polyphenol and total flavonoid contents; 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assay, and levels of pro-inflammatory mediators such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6). The total polyphenol contents of GPLE and PLE were determined to be 224.44 ± 1.54 and 197.33 ± 5.81 mg gallic acid equivalents (GAE)/g, respectively, and the total flavonoid contents of GPLE and PLE were 206.27 ± 1.15 and 167.60 ± 2.00 mg quercetin equivalents (QUE)/g, respectively. The anti-oxidant activities of GPLE and PLE as measured by DPPH assays were 338.33 ± 30.19 μg/ml (IC50) and 388.68 ± 8.45 μg/ml (IC50), respectively, and those measured by ABTS assays were 510.49 ± 15.12 μg/ml (IC50) and 731.30 ± 10.63 μg/ml (IC50), respectively. IC50 is the inhibitor concentration that reduces the response by 50%. GPLE strongly inhibited the production of NO, PGE2 and IL-6 compared with PLE in lipopolysaccharide-stimulated RAW264.7 macrophages. Furthermore, GPLE significantly inhibited the production of TNF-α and IL-6 cytokines compared with PLE in phorbol 12-myristate 13-acetate (PMA) plus A23187-stimulated HMC-1 human mast cells. These results indicate that gamma irradiation of PLE can enhance its anti-oxidative and anti-inflammatory activities through elevation of the phenolic contents. Therefore, gamma-irradiated PLE has potential for use in the food and cosmetic industries.

scholarly journals Effect of Persimmon Leaf Extract on Phthalic Anhydride-induced Allergic Response in Mice

2012 ◽  
Vol 17 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Ji-Ye Mok ◽  
In-Hwa Jeon ◽  
Jung-Keun Cho ◽  
Ji-Min Park ◽  
Hyeon-Soo Kim ◽  
...  
Keyword(s):  
Phthalic Anhydride ◽  
Leaf Extract ◽  
Allergic Response ◽  
Persimmon Leaf Extract ◽  
Persimmon Leaf
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