Methyl donor supplementation of gestating sow diets improves pregnancy outcomes and litter size

2013 ◽  
Vol 53 (1) ◽  
pp. 1 ◽  
Author(s):  
W. H. E. J. van Wettere ◽  
R. J. Smits ◽  
P. E. Hughes
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Litter Size ◽  
Early Pregnancy ◽  
Pregnancy Outcomes ◽  
Large White ◽  
Methyl Donors ◽  
Homocysteine Concentration ◽  
Vitamin B12 Supplementation ◽  
Betaine Supplementation

Maternal intake of B-vitamin and methyl donors can affect sow prolificacy. A total of 1079 Large White/Landrace sows (parities 2–9 at mating) were used in a 2 by 2 by 2 factorial design to determine the effects of two levels of betaine supplementation (0 versus 3 g added betaine/kg feed), two levels of folic acid plus vitamin B12 supplementation (0 versus 20 mg/kg folic acid plus 150 µg/kg vitamin B12) during gestation, and two parity groups (parity 2 and 3 versus parity 4 and greater) on litter size and pregnancy outcomes. The number of sows returning to oestrus post-insemination, as well as the number of early (<Day 30) and late (>Day 30) pregnancy losses were recorded. At farrowing, the total number of piglets born, the number of piglets born alive and dead, as well as the number of mummified fetuses were recorded. Pre-prandial blood samples were collected from a subset of 20 sows/treatment on Days 3, 30 and 107 of gestation to analyse homocysteine. The incidence of early pregnancy loss was reduced (P < 0.001) by folic acid plus vitamin B12 supplementation (0.03 versus 0.07). There was a significant interaction between parity at mating (parities 2 and 3 versus parity 4 and greater) and the addition of betaine or folic acid plus vitamin B12 to the gestation diet on litter size. Litter size was higher (0.5 piglets; P < 0.05) for betaine supplemented, compared with unsupplemented, parity 4 plus sows. Folic acid plus vitamin B12-supplemented parity 2 and 3 sows gave birth to more (P < 0.05) piglets than all other treatment groups. Folic acid plus vitamin B12 supplementation decreased (P < 0.001) plasma homocysteine concentration by 2.2 and 2.8 μM, respectively, on Days 3 and 107 of gestation. However, betaine supplementation decreased (P < 0.05) homocysteine on Day 3 only. Overall, folic acid plus vitamin B12 supplementation decreased incidences of early pregnancy failure and increased litter size in early parity sows, while betaine increased litter size in older parity sows.

scholarly journals Long-term Effect of Folic Acid and Vitamin B12 Supplementation on Fracture Risk and Cardiovascular Disease: Follow-up Study of B-PROOF Trial (P24-031-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C Kiefte-de Jong ◽  
Suzanne van Dijk ◽  
Natasja van Schoor ◽  
Lisette CPGM de Groot ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Homocysteine Level ◽  
Fracture Incidence ◽  
Total Homocysteine ◽  
The Hague ◽  
Vitamin B12 Supplementation

Abstract Objectives To investigate the possible effects of the intervention with folic acid and vitamin B12 supplementation on fracture and cardiovascular disease risk: 5–7 years after the end of the intervention period of 2–3 years. Methods Extended follow-up of B-PROOF trial, a multi-center, double-blind randomized placebo-controlled trial designed to assess the effect of 2–3 years daily supplementation with folic acid (400 µg) and vitamin-B12 (500 µg) versus placebo on fracture incidence. Fracture and cardiovascular outcomes were assessed by follow-up questionnaire. Fracture incidence (and a part of cardiovascular disease incidence) was verified by general practitioners (GPs). Results A total of 1298 individuals participated in the second follow-up round. Median age at baseline was 71.0 years [68.0–76.0] for both groups (n = 662 in the treatment group and n = 636 in the placebo group). No effect of the intervention on first osteoporotic fracture and other fracture risk after a follow up of 5–7 years was observed (HR: 0.99, 95% CI: 0.62; 1.59 and HR: 0.77; 95% CI: 0.50; 1.19, respectively) and also not for cardiovascular- or cerebrovascular disease (OR: 1.14; 95%CI: 0.74–1.74 and OR: 1.01; 95%CI: 0.76–1.33, respectively). Significant interaction for total homocysteine level was observed for osteoporotic- and any fracture (P = 0.10 and 0.06 resp.), which indicated a significantly lower risk of fracture in the intervention group with higher total homocysteine level. Conclusions This study does not support a prolonged effect of supplementation of folic acid and vitamin B12 on fracture risk, or on cardiovascular disease in older individuals with elevated homocysteine concentration. However, B-vitamin supplementation may be beneficial in reducing fractures in individuals with higher total homocysteine levels. Funding Sources The initial B-PROOF study has received funding so far by The Netherlands Organization for Health Research and Development (ZonMw), the Hague; unrestricted grant from NZO (Dutch Dairy Association), Zoetermeer; Orthica, Almere; NCHA (Netherlands Consortium Healthy Ageing) Leiden/Rotterdam; Ministry of Economic Affairs, Agriculture and Innovationn, the Hague; Wageningen University, Wageningen; VUmc, Amsterdam; Erasmus Medical Center, Rotterdam. Supporting Tables, Images and/or Graphs

scholarly journals Long-term effects of folic acid and vitamin-B12 supplementation on fracture risk and cardiovascular disease: Extended follow-up of the B-PROOF trial

2020 ◽  
Author(s):  
Sadaf Oliai Araghi ◽  
Jessica C. Kiefte-de Jong ◽  
Suzanne C. van Dijk ◽  
Karin M.A. Swart ◽  
Kim J. Ploegmakers ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Fracture Risk ◽  
Vitamin B12 ◽  
Long Term Effects ◽  
Vitamin B12 Supplementation

Effects of Folic Acid and Vitamin B12 Supplementation on Granulosa Cells of the Dominant Follicle of Dairy Cows.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 504-504 ◽  
Author(s):  
Annie Gagnon ◽  
Marc-André Sirard ◽  
François Richard ◽  
Jean-Paul Laforest
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Dairy Cows ◽  
Granulosa Cells ◽  
Dominant Follicle ◽  
Vitamin B12 Supplementation

scholarly journals Effects of folic acid and vitamin B12 supplementation on culling rate, diseases, and reproduction in commercial dairy herds

2014 ◽  
Vol 97 (4) ◽  
pp. 2346-2354 ◽  
Author(s):  
M. Duplessis ◽  
C.L. Girard ◽  
D.E. Santschi ◽  
J.-P. Laforest ◽  
J. Durocher ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Dairy Herds ◽  
Vitamin B12 Supplementation

EFFECTS OF FOLIC ACID AND VITAMIN B12 SUPPLEMENTATION ON NEGATIVE SYMPTOMS AND RELATED MRI INDICES

2014 ◽  
Vol 153 ◽  
pp. S80 ◽  
Author(s):  
Joshua Roffman ◽  
Steven J. Lamberti ◽  
Eric Achtyes ◽  
Eric A. Macklin ◽  
Gail C. Galendez ◽  
...  
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Negative Symptoms ◽  
Vitamin B12 Supplementation

Homocysteine, folic acid and vitamin B12 in relation to pre- and postnatal health aspects

2005 ◽  
Vol 43 (10) ◽  
Author(s):  
Rima Obeid ◽  
Wolfgang Herrmann
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Pregnancy Outcomes ◽  
Pregnancy Complications ◽  
Plasma Homocysteine ◽  
Vitamin B ◽  
Total Plasma ◽  
Vitamin Status ◽  
B Vitamin ◽  
Early Abortion

AbstractStudies linking hyperhomocysteinemia (HHCY) and B-vitamin deficiency to some health aspects in children have been accumulating. Low B-vitamin status inearly life, even as early as the time of conception, may endanger the potential for new life and may negatively influence the health of the offspring. Early abortion, pregnancy complications and poor pregnancy outcomes have been linked to elevated concentrations of total plasma homocysteine (tHcy) and low folate or vitamin B

scholarly journals The role of increased levels of homocysteine in the development of cardiovascular diseases

2006 ◽  
Vol 59 (3-4) ◽  
pp. 143-147 ◽  
Author(s):  
Zoran Ceperkovic
Keyword(s):  
Folic Acid ◽  
Amino Acid ◽  
Cardiovascular Diseases ◽  
Vitamin B12 ◽  
Vitamin B6 ◽  
Heart Diseases ◽  
Daily Intake ◽  
Cholesterol Oxidation ◽  
Total Risk ◽  
Homocysteine Concentration

Introduction. Homocysteine is a sulphur amino acid produced by demethylation of the essential amino acid methionine. Dysfunction of certain enzymes or insufficient intake of nutrients may cause increase of intracellular homocysteine, which is then exported into plasma. Etiopathogenesis of cardiovascular diseases accompanied with higher level of homocysteine. McCully's theory suggests that high levels of homocysteine are associated with cardiovascular diseases, arteriosclerosis and endothelial dysfunction. Harmful effects of homocysteine are associated with LDL cholesterol oxidation, increased production of collagen, lower availability of nitric oxide as well as prothrombotic activity. Reduction of homocysteine levels. The most recent researches show that hyperhomocysteinemia is responsible for about 10% of total risk of cardiovascular diseases. Vitamin BJ2 plays a major role in the remethylation of homocysteine. Reducing the homocysteine concentration in blood by 3 mol/l (with daily intake of 0.8 mg of folic acid) reduces the risk of ishemic heart diseases by 16%, vein thrombosis by 25%, and stroke by 24%. A six-month therapy with folic acid (Img/d), vitamin B12 (400g/d) and vitamin B6 (10mg/d), reduces the frequency of cardiovascular occurrences after successful PTCA. Plasma homocysteine concentration over 12/1 doubles the risk of myocardial infarction. Conclusion. A lack of folates, vitamin B6 and vitamin B12 increases the level of homocysteine and thus increases the risk of cardiovascular diseases. Changes in lifestyle and diet, as well as intake of food supplements, are of great importance in reducing homocysteine levels in plasma and therefore in reducing the occurrence and acceleration of arteriosclerosis. .

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