Vortex Fluidic Ethenolysis, Integrating a Rapid Quench of Ruthenium Olefin Metathesis Catalysts

2020 ◽  
Vol 73 (12) ◽  
pp. 1138
Author(s):  
Scott J. Pye ◽  
Justin M. Chalker ◽  
Colin L. Raston
Keyword(s):  
Thin Film ◽  
Olefin Metathesis ◽  
Continuous Flow ◽  
Rapid Quenching ◽  
Flow Process ◽  
Rapid Quench ◽  
Metathesis Catalyst ◽  
Fluidic Device ◽  
Continuous Flow Process ◽  
Metathesis Catalysts

Ruthenium-catalysed ethenolysis occurs in a vortex fluidic device (VFD) – a scalable, thin-film microfluidic continuous flow process. This process takes advantage of the efficient mass transfer of gaseous reagents into the dynamic thin film of liquid. Also reported is the rapid quenching of the ruthenium-based olefin metathesis catalyst by the addition of a saturated solution of N-acetyl-l-cysteine in MeCN, as a convenient alternative to previously reported quenching methods.

A Continuous Flow Process for LSN647712 via Double Organometallic Additions to Dimethylcarbamyl Chloride

2021 ◽  
Author(s):  
Hui Li ◽  
Jillian W. Sheeran ◽  
David Kouvchinov ◽  
Andrew M. Clausen ◽  
Ian T. Crouch ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

2017 ◽  
Vol 2 (2) ◽  
pp. 149-158 ◽  
Author(s):  
Romaric Gérardy ◽  
Marc Winter ◽  
Alessandra Vizza ◽  
Jean-Christophe M. Monbaliu
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Development of a scalable continuous-flow process towards enriched threo-methylphenidate (Ritalin) hydrochloride.

Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzene

2016 ◽  
Vol 20 (2) ◽  
pp. 199-203 ◽  
Author(s):  
Zhiqun Yu ◽  
Pengcheng Zhou ◽  
Jiming Liu ◽  
Wenzuo Wang ◽  
Chuanming Yu ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Quest for the ideal olefin metathesis catalyst

2008 ◽  
Vol 80 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Anna Michrowska ◽  
Karol Grela
Keyword(s):  
Oxygen Atom ◽  
Quaternary Ammonium ◽  
Olefin Metathesis ◽  
Amino Group ◽  
Sulfonated Polystyrene ◽  
Grubbs Catalyst ◽  
Metathesis Catalyst ◽  
Metathesis Catalysts ◽  
Novel Strategy ◽  
The Ideal

Attempts were made to create a catalyst that approaches Gladysz's vision of an "ideal catalyst". Modifications of the Hoveyda-Grubbs catalyst were carried out with the aim to increase its activity and broaden the scope of its applicability to challenging metathesis reactions. This was done by introduction of an electron-withdrawing substituent on the isopropoxybenzylidene group in order to diminish the donor properties of the oxygen atom. The resulting stable and easily accessible nitro-substituted Hoveyda-Grubbs catalyst has found a number of successful applications in various research and industrial laboratories. Also, a new concept for noncovalent immobilization of a ruthenium olefin metathesis catalyst is presented. The 2-isopropoxybenzylidene ligand of Hoveyda-Grubbs carbene is further modified by an additional amino group, and immobilization is achieved by treatment with sulfonated polystyrene, forming the corresponding ammonium salt. In this novel strategy for the immobilization of ruthenium-based metathesis catalysts, the amino group plays a dual role, being first an active anchor for immobilization and secondly, after protonation, activating the catalysts by electron-donating to -withdrawing switch. The same concept has been used in the preparation of a quaternary ammonium catalyst for aqueous olefin metathesis.

Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone

2018 ◽  
Vol 22 (8) ◽  
pp. 1022-1028 ◽  
Author(s):  
Avedis Karadeolian ◽  
Dineshkumar Patel ◽  
Prabhudas Bodhuri ◽  
Gamini Weeratunga ◽  
Boris Gorin
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process

Continuous flow synthesis of amine oxides by oxidation of tertiary amines

2019 ◽  
Vol 4 (7) ◽  
pp. 1270-1276
Author(s):  
Tobias Baumeister ◽  
Stefan Zikeli ◽  
Hannes Kitzler ◽  
Paul Aigner ◽  
Piotr P. Wieczorek ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Continuous Flow ◽  
Tertiary Amines ◽  
Flow Process ◽  
Flow Synthesis ◽  
Amine Oxides ◽  
Continuous Flow Process

An efficient, safe and scalable continuous flow process for the synthesis of amine oxides with hydrogen peroxide is described.

Development of a Continuous Flow Process for a Matteson Reaction: From Lab Scale to Full-Scale Production of a Pharmaceutical Intermediate

2019 ◽  
Vol 23 (5) ◽  
pp. 1069-1077 ◽  
Author(s):  
Clemens Stueckler ◽  
Peter Hermsen ◽  
Bas Ritzen ◽  
Maria Vasiloiu ◽  
Peter Poechlauer ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Full Scale ◽  
Scale Production ◽  
Flow Process ◽  
Continuous Flow Process

Design of a microfluidic device for the measurement of the elastic modulus of deformable particles

Soft Matter ◽  
2019 ◽  
Vol 15 (5) ◽  
pp. 880-889 ◽  
Author(s):  
Massimiliano M. Villone ◽  
Janine K. Nunes ◽  
Yankai Li ◽  
Howard A. Stone ◽  
Pier Luca Maffettone
Keyword(s):  
Elastic Modulus ◽  
Interfacial Tension ◽  
Continuous Flow ◽  
Liquid Droplet ◽  
Flow Process ◽  
Deformable Particles ◽  
Soft Particles ◽  
Continuous Flow Process ◽  
Microfluidic Technique

A microfluidic technique recently proposed in the literature to measure the interfacial tension between a liquid droplet and an immiscible suspending liquid [Hudson et al., Appl. Phys. Lett., 2005, 87, 081905], [Cabral and Hudson, Lab Chip, 2006, 6, 427] is suitably adapted to the characterization of the elastic modulus of soft particles in a continuous-flow process.

Effective production of the biodiesel additive STBE by a continuous flow process

2011 ◽  
Vol 102 (19) ◽  
pp. 9304-9307 ◽  
Author(s):  
Jean-Christophe M. Monbaliu ◽  
Marc Winter ◽  
Bérengère Chevalier ◽  
Frank Schmidt ◽  
Yi Jiang ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Process ◽  
Continuous Flow Process
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