scholarly journals Some nitro- and amino-compounds prepared from naturally occurring 2,2-dimethylchromenes

1954 ◽  
Vol 7 (2) ◽  
pp. 166 ◽  
Author(s):  
DJ McHugh ◽  
SE Wright
Keyword(s):  
Nitro Compounds ◽  
Antibiotic Activity ◽  
Naturally Occurring ◽  
Amino Compounds

The preparation of some nitro-compounds of alloevodionol and dihydromethylevodionol is described. Aminodihydromethylevodionol has also been prepared and found to be too toxic for pharmacological use and devoid of antibiotic activity.

ChemInform Abstract: Naturally-Occurring Nitro Compounds

ChemInform ◽  
2011 ◽  
Vol 42 (18) ◽  
pp. no-no
Author(s):  
Ronald Parry ◽  
Shirley Nishino ◽  
Jim Spain
Keyword(s):  
Nitro Compounds ◽  
Naturally Occurring

The Structural Gene for Microcin H47 Encodes a Peptide Precursor with Antibiotic Activity

1999 ◽  
Vol 43 (9) ◽  
pp. 2176-2182 ◽  
Author(s):  
Eliana Rodríguez ◽  
Carina Gaggero ◽  
Magela Laviña
Keyword(s):  
Escherichia Coli ◽  
Gene Fusion ◽  
Genetic System ◽  
Antibiotic Activity ◽  
Peptide Antibiotic ◽  
Bifunctional Protein ◽  
Naturally Occurring ◽  
Hydrophobic Peptide ◽  
Peptide Precursor ◽  
Highly Hydrophobic

ABSTRACT Microcin H47 is a bactericidal antibiotic produced by a naturally occurring Escherichia coli strain isolated in Uruguay. The microcin genetic system is located in the chromosome and extends over a 10-kb DNA segment containing the genes required for microcin synthesis, secretion, and immunity. The smallest microcin synthesis gene,mchB, was sequenced and shown to encode a highly hydrophobic peptide. An mchB-phoA gene fusion, which directed the synthesis of a hybrid bifunctional protein with both PhoA and microcin H47-like activities, was isolated. The results presented herein lead us to propose that microcin H47 is indeed a ribosomally synthesized peptide antibiotic and that its peptide precursor already has antibiotic activity of the same specificity as that of mature microcin.

The antibacterial activity of some naturally occurring 2,5-dihydroxy-l,4-benzoquinones

1984 ◽  
Vol 30 (8) ◽  
pp. 1068-1072 ◽  
Author(s):  
D. Brewer ◽  
W.-C. Jen ◽  
G. A. Jones ◽  
A. Taylor
Keyword(s):  
Antibacterial Activity ◽  
Related Compound ◽  
Antibiotic Activity ◽  
Number Of Species ◽  
Naturally Occurring ◽  
Metabolic Products

Polyporic acid, atromentin, bovinone, and oosporein are common metabolic products of a number of species of fungi. The related compound cochliodinol and its congeners are produced by several Chaetomium spp. These quinonoid metabolites have been shown to inhibit the growth and metabolism of a range of bacterial genera. The antibiotic activity of the quinones depends on the substituents at the 3 and 6 positions of the 2,5-dihydroxy-1,4-benzoquinone ring; in aerobic systems the activity appears to be inversely proportional to the polarity of the metabolite. It has been shown that reduction of the quinone to the hydroquinone changes the antibiotic activity of these metabolites but does not abolish it. Contrary to previous reports, the activity of these hydroquinones is not reversed by cysteine.

An Efficient Fe/H2O Medium in situ Reduction and Cyclization Reaction for the Synthesis of Pyrazolo[3,4-a]acridin-10-one and Pyrazolo[4,3-a]acridin-10-one Derivatives

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 583-592 ◽  
Author(s):  
Liangce Rong ◽  
Hui Xu ◽  
Lei Li ◽  
Cong Lin ◽  
Wang Kou ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Raw Materials ◽  
Environmentally Friendly ◽  
Nitro Compounds ◽  
The Other ◽  
Cyclization Reaction ◽  
In Situ Reduction ◽  
Simple Method ◽  
Amino Compounds

An efficient and simple method for the synthesis of pyrazolo[3,4-a]acridine and pyrazolo[4,3-a]acridine derivatives directly form nitro compounds by in situ reduction and cyclization reaction under Fe/H2O medium is reported. Compared to amino compounds, nitro compounds are more stable and easier to obtain. In addition, because iron is a nontoxic, inexpensive, and environmentally friendly reductant, this method is especially suitable for organic synthesis. The other advantages of this process are cheap raw materials, less pollution, and wide substrate range.

scholarly journals (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-Mono(di,tri)fluoromethylcyclopropyl]alanines and their incorporation into hormaomycin analogues

2014 ◽  
Vol 10 ◽  
pp. 2844-2857 ◽  
Author(s):  
Armin de Meijere ◽  
Sergei I Kozhushkov ◽  
Dmitrii S Yufit ◽  
Christian Grosse ◽  
Marcel Kaiser ◽  
...  
Keyword(s):  
Antibiotic Activity ◽  
Chiral Auxiliaries ◽  
Enantiomerically Pure ◽  
Naturally Occurring

Efficient and scalable syntheses of enantiomerically pure (2R,1'S,2'R)- and (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl]alanines 9a–c, as well as allo-D-threonine (4) and (2S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S)- and (R)-2-[(N-benzylprolyl)amino]benzophenone [(S)- and (R)-10] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin (1) with (fluoromethylcyclopropyl)alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity.

Naturally-occurring nitro compounds

2011 ◽  
Vol 28 (1) ◽  
pp. 152-167 ◽  
Author(s):  
Ronald Parry ◽  
Shirley Nishino ◽  
Jim Spain
Keyword(s):  
Nitro Compounds ◽  
Naturally Occurring

Pathology of Bone Cells in Pigs with Experimental Turbinate Osteoporosis (Atrophic Rhinitis)

1971 ◽  
Vol 29 ◽  
pp. 304-305
Author(s):  
A. W. Fetter ◽  
C. C. Capen
Keyword(s):  
Mucous Membrane ◽  
Bone Cells ◽  
Atrophic Rhinitis ◽  
Infectious Agents ◽  
Metabolic Disturbances ◽  
Progressive Reduction ◽  
Naturally Occurring ◽  
Fundamental Cause ◽  
Osteocytic Osteolysis ◽  
Uncertain Etiology

Atrophic rhinitis in swine is a disease of uncertain etiology in which infectious agents, hereditary predisposition, and metabolic disturbances have been reported to be of primary etiologic importance. It shares many similarities, both clinically and pathologically, with ozena in man. The disease is characterized by deformity and reduction in volume of the nasal turbinates. The fundamental cause for the localized lesion of bone in the nasal turbinates has not been established. Reduced osteogenesis, increased resorption related to inflammation of the nasal mucous membrane, and excessive resorption due to osteocytic osteolysis stimulated by hyperparathyroidism have been suggested as possible pathogenetic mechanisms.The objectives of this investigation were to evaluate ultrastructurally bone cells in the nasal turbinates of pigs with experimentally induced atrophic rhinitis, and to compare these findings to those in control pigs of the same age and pigs with the naturally occurring disease, in order to define the fundamental lesion responsible for the progressive reduction in volume of the osseous core.

High Resolution Replication of Organoclay Surfaces

1982 ◽  
Vol 40 ◽  
pp. 576-577
Author(s):  
W. W. Barker ◽  
W. E. Rigsby ◽  
V. J. Hurst ◽  
W. J. Humphreys
Keyword(s):  
Clay Mineral ◽  
Organic Molecule ◽  
Organic Molecules ◽  
X Ray Diffraction ◽  
Xrd Pattern ◽  
X Ray ◽  
Naturally Occurring ◽  
Silicate Layers ◽  
Mineral Identification

Experimental clay mineral-organic molecule complexes long have been known and some of them have been extensively studied by X-ray diffraction methods. The organic molecules are adsorbed onto the surfaces of the clay minerals, or intercalated between the silicate layers. Natural organo-clays also are widely recognized but generally have not been well characterized. Widely used techniques for clay mineral identification involve treatment of the sample with H2 O2 or other oxidant to destroy any associated organics. This generally simplifies and intensifies the XRD pattern of the clay residue, but helps little with the characterization of the original organoclay. Adequate techniques for the direct observation of synthetic and naturally occurring organoclays are yet to be developed.

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