Risk factors for cervical cancer development: what do women think?

Sexual Health ◽  
2004 ◽  
Vol 1 (3) ◽  
pp. 145 ◽  
Author(s):  
M. F. D. Baay ◽  
V. Verhoeven ◽  
D. Avonts ◽  
J. B. Vermorken
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Viral Infection ◽  
Genetic Factors ◽  
Cervical Cancer Prevention ◽  
Cancer Development ◽  
Biomedical Sciences ◽  
Sexually Transmitted ◽  
Number Of Sexual Partners ◽  
Cervical Cancer Development

Background: The current cervical cancer prevention strategy is exclusively directed towards screening, without taking into account any relationship with sexual risk factors. The introduction of human papillomavirus (HPV) detection into the screening procedure implicates that we should give attention to this relationship. The aim of this study was to investigate what knowledge women have of the relation between HPV and cervical cancer. Methods: Rather than asking about HPV specifically, we suggested 20 risk factors for the development of cervical cancer, including viral infection, and asked 73 women visiting their general practitioner, 67 women visiting a lecture on risk factors for cervical cancer and 28 female students in biomedical sciences to rate the importance of these risk factors on a scale of 1–5. Results: Genetic factors were rated highest with a mean score of 4.5. Bacterial infection ranked second highest with a mean score of 3.8. Smoking ranked fourth at a mean score of 3.6, whereas viral infection shared the sixth place with number of sexual partners with a mean score of 3.4. The presence of high voltage power lines and physical activity appropriately scored the last two places at 2.4 and 2.2, respectively. Twenty-one women suggested a role for sexually transmitted agents, but only five women (3.1%) could actually pinpoint HPV. Conclusion: This enquiry indicates that the risk factor ‘genetic factors’ was over-rated, while knowledge of the most important risk factors, i.e. smoking and sexual habits and (sexually transmitted) infections, would appear to be present to a moderate level in our population. However, knowledge of the role of HPV in cervical cancer development is lacking.

General practitioners’ perception of risk factors for cervical cancer development: Consequences for patient education

2006 ◽  
Vol 62 (2) ◽  
pp. 277-281 ◽  
Author(s):  
Marc F.D. Baay ◽  
Veronique Verhoeven ◽  
Lieve Peremans ◽  
Dirk Avonts ◽  
Jan Baptist Vermorken
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Patient Education ◽  
General Practitioners ◽  
Cancer Development ◽  
Perception Of Risk ◽  
Cervical Cancer Development

scholarly journals Human papillomavirus and other risk factors in Lithuanian cervical carcinoma patients

2010 ◽  
Vol 17 (3-4) ◽  
pp. 106-115
Author(s):  
Živilė GUDLEVIČIENĖ ◽  
Alė SMILGEVIČIŪTĖ-IVSHIN ◽  
Aurelija VAITKUVIENĖ ◽  
Agnė ŠEPETIENĖ ◽  
Janina DIDŽIAPETRIENĖ
Keyword(s):  
Risk Factors ◽  
Cervical Cancer ◽  
Cancer Risk ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cancer Risk Factors ◽  
Cervical Cancer Risk ◽  
Hpv Prevalence ◽  
Geographical Regions ◽  
Cervical Cancer Development

Background. Cervical cancer is the second biggest cause of female cancer mortality worldwide and the most common cancer in women in Lithuania. The incidence of cervical cancer is strongly associated with HPV prevalence. However, not only HPV infection plays a crucial role in cervical cancer development; other risk factors which vary in different populations and geographical regions as well as HPV prevalence are important. The aim of this study was to detect the HPV, its type’s prevalence and other cervical cancer risk factors for Lithuanian women. Materials and methods. 191 women with primary diagnosed invasive cervical cancer (cases group) and 397 control women were invited to participate in the study. All women were interviewed and samples for HPV testing were taken. Results. In the cases group, 92.7% of women and in the control group 26.7% were infected by HPV (p < 0.0001). HPV 16 was the most common type in both groups. HPV infection increases the risk of cervical cancer 75 times (OR = 75.39; 95% CI 33.61–192.98). Women with lower education, workers, those who started sexual intercourses before 20 years of age, at older age of the first menstrual period, 3–5 or more childbirths, smokers and with a long ago or never performed Pap test are at a significantly higher risk of cervical cancer development. Other non-HPV risk factors were not associated with cervical cancer risk. Conclusions. Data of our study show a high prevalence of HPV in Lithuanian population. It may have an impact on the biggest cervical cancer incidence. The other risk factors are similar as in other lower economic resource countries. Keywords: HPV, cervical cancer, risk factors

miR-122 Inhibits the Cervical Cancer Development by Targeting the Oncogene RAD21

2021 ◽  
Author(s):  
Yanling Yang ◽  
Yang Liu ◽  
Wei Liu ◽  
Chunyang Li ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development

2016 ◽  
Vol 88 (9) ◽  
pp. 1646-1651 ◽  
Author(s):  
A. Pontillo ◽  
P. Bricher ◽  
V.N.C. Leal ◽  
S. Lima ◽  
P.R.E. Souza ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Hpv Infection ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Genetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G

2011 ◽  
Vol 27 (4) ◽  
pp. 1188-1192 ◽  
Author(s):  
S. OLIVEIRA ◽  
J. RIBEIRO ◽  
H. SOUSA ◽  
D. PINTO ◽  
I. BALDAQUE ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Genetic Polymorphisms ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Human Papillomavirus 16 Oncoproteins Downregulate the Expression of miR-148a-3p, miR-190a-5p, and miR-199b-5p in Cervical Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Mi-Soon Han ◽  
Jae Myun Lee ◽  
Soo-Nyung Kim ◽  
Jae-Hoon Kim ◽  
Hyon-Suk Kim
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
High Risk ◽  
Expression Profiles ◽  
Normal Group ◽  
Cancer Development ◽  
Hybridization Method ◽  
Cancer Group ◽  
Cervical Cancer Development ◽  
High Risk Hpv

Almost all cervical cancers are associated with human papillomavirus (HPV); however, the majority of women infected with this virus do not develop cervical cancer. Therefore, new markers are needed for reliable screening of cervical cancer, especially in relation to HPV infection. We aimed to identify potential microRNAs that may serve as diagnostic markers for cervical cancer development in high-risk HPV-positive patients. We evaluated the microRNA expression profiles in 12 cervical tissues using the hybridization method and verified them by quantitative polymerase chain reaction (qPCR). Finally, we evaluated the effects of HPV16 oncoproteins on the expression of selected microRNAs using cervical cancer cells (CaSki and SiHa) and RNA interference. With the hybridization method, eight microRNAs (miR-9-5p, miR-136-5p, miR-148a-3p, miR-190a-5p, miR-199b-5p, miR-382-5p, miR-597-5p, and miR-655-3p) were found to be expressed differently in the HPV16-positive cervical cancer group and HPV16-positive normal group (fold change ≥ 2). The results of qPCR showed that miR-148a-3p, miR-190a-5p, miR-199b-5p, and miR-655-3p levels significantly decreased in the cancer group compared with the normal group. Upon silencing of HPV16 E5 and E6/E7, miR-148a-3p levels increased in both cell lines. Silencing of E6/E7 in SiHa cells led to the increase in miR-199b-5p and miR-190a-5p levels. Three HPV16 oncoproteins (E5, E6, and E7) downregulate miR-148a-3p, while E6/E7 inhibit miR-199b-5p and miR-190a-5p expression in cervical carcinoma. The three microRNAs, miR-148a-3p, miR-199b-5p, and miR-190a-5p, may be novel diagnostic biomarkers for cervical cancer development in high-risk HPV-positive patients.

SMAD2 rs4940086 heterozygosity increases the risk of cervical cancer development among the women in Bangladesh

2020 ◽  
Vol 47 (7) ◽  
pp. 5033-5040
Author(s):  
Parsa Sanjana Haque ◽  
Mohd Nazmul Hasan Apu ◽  
Noor Ahmed Nahid ◽  
Farhana Islam ◽  
Md Reazul Islam ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Development ◽  
Cervical Cancer Development

scholarly journals Human papillomavirus genotyping as a tool for cervical cancer prevention: from commercially available human papillomavirus DNA test to next-generation sequencing

2020 ◽  
Vol 6 (9) ◽  
pp. FSO603
Author(s):  
Tauana Christina Dias ◽  
Adhemar Longatto-Filho ◽  
Nathalia C Campanella
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cervical Cancer Prevention ◽  
Cancer Development ◽  
Cervical Carcinogenesis ◽  
Dna Test ◽  
First Time ◽  
Papillomavirus Dna ◽  
Principal Elements ◽  
Generation Sequencing

The biological importance of human papillomavirus (HPV) in the field of medicine – related to cervical carcinogenesis – has been extensively reported in the last decades. For the first time, a direct correlation between cause and effect to explain a cancer development was completely achieved in medical research. Consequently, the Nobel Prize was awarded to HZ Hausen in 2008 for his efforts to understand the effects of persistent infection of oncogenic types of HPV and malignancy transformation. The aim of the present review was to summarize the principal elements of HPV characteristics and their importance in oncology.

scholarly journals From Microbiome to Inflammation: The Key Drivers of Cervical Cancer

2021 ◽  
Vol 12 ◽  
Author(s):  
Zi-Wei Zhou ◽  
Hui-Zhi Long ◽  
Yan Cheng ◽  
Hong-Yu Luo ◽  
Dan-Dan Wen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Development ◽  
The Third ◽  
Host Body ◽  
Key Drivers ◽  
Cervical Cancer Development ◽  
The Relationship

Cervical cancer is the third leading cause of cancer-related death worldwide. Microbes and hosts form a mutually beneficial symbiosis relationship, and various parts of the host body are microbial habitats. Microbes can trigger inflammation in certain parts of the host body, contributing to cervical cancer development. This article reviews the relationship between cervicovaginal microbes, inflammation and cervical cancer, and discusses the effect of some key cervical microbes on cervical cancer. Finally, probiotic therapy and immunotherapy are summarized.

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