Some haematological data from an experimental colony of rabbits, Oryctolagus cuniculus (L)

1962 ◽  
Vol 10 (4) ◽  
pp. 587 ◽  
Author(s):  
ML Dudzinski ◽  
ER Hesterman ◽  
R Mykytowycz
Keyword(s):  
Blood Cell ◽  
Oryctolagus Cuniculus ◽  
Haemoglobin Concentration ◽  
Significant Rise ◽  
High Population Density ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts ◽  
Experimental Enclosure ◽  
Haematological Data

An analysis of haematological data collected during a period of 22 months from a colony of Australian wild rabbits, Oryctolagus cuniculus (L.), living in a 1.7-acre experimental enclosure, is presented. Erythrocyte, leucocyte, and reticulocyte counts were made, and the level of haemoglobin was determined in 815 blood samples taken at regular monthly intervals. Differences between sexes, ages, and seasons were examined statistically for various blood values. Haemoglobin concentration and red blood cell counts fell when the rabbit population rose above approximately 50 per acre but there was not a statistically significant rise in the counts of reticulocytes. White blood cell counts rose during breeding fights and high population density.

Use of combined conventional and real-time PCR to determine the epidemiology of feline haemoplasma infections in northern Italy

2009 ◽  
Vol 11 (4) ◽  
pp. 277-285 ◽  
Author(s):  
Fabio Gentilini ◽  
Marilisa Novacco ◽  
Maria E. Turba ◽  
Barbara Willi ◽  
Maria L. Bacci ◽  
...  
Keyword(s):  
Blood Cell ◽  
Disease Transmission ◽  
Odds Ratio ◽  
Haemoglobin Concentration ◽  
Northern Italy ◽  
Blood Collection ◽  
Convenience Sample ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

Although knowledge of feline haemotropic mycoplasmas (haemoplasmas) has dramatically improved in recent years, some issues still remain to be elucidated. The aim of the current study was to evaluate the prevalence of feline haemoplasma infections in blood samples collected from cats in northern Italy. A convenience-sample of 307 cats (40 anaemic; 258 non-anaemic; nine with unknown haematocrit [HCT]) was investigated using polymerase chain reaction assays. Furthermore, the date of blood collection, signalment and clinicopathological data were retrospectively evaluated to assess predictors and risk factors for infection. Haemoplasma infections were highly prevalent in the sample investigated with an overall prevalence of 18.9% (95% confidence interval: 14.5–23.3%). The prevalence for the three feline haemoplasmas was 17.3% for ‘ Candidatus Mycoplasma haemominutum’ ( CMhm), 5.9% for Mycoplasma haemofelis ( Mhf) and 1.3% for ‘ Candidatus Mycoplasma turicensis’ ( CMt). Feline immunodeficiency virus-positive status represented a risk factor for infection with an odds ratio of 4.19 ( P=0.02). Moreover, a higher prevalence was observed in summer (odds ratio 1.78; P=0.04) which may be consistent with arthropod-borne disease transmission. Cats infected with Mhf showed significantly lower HCT ( P=0.03), haemoglobin values ( P=0.02) and red blood cell counts ( P=0.04), lower mean corpuscular haemoglobin concentration ( P<0.01) and higher white blood cell counts ( P<0.01) when compared with non-infected cats.

An Alternative Elastase-mediated Degradation of Fibrinogen and Fibrin Observed in a Patient with Herpes Simplex Encephalitis and Pneumonia

1996 ◽  
Vol 76 (02) ◽  
pp. 184-186 ◽  
Author(s):  
Kenji lijima ◽  
Fumiyo Murakami ◽  
Yasushi Horie ◽  
Katsumi Nakamura ◽  
Shiro Ikawa ◽  
...  
Keyword(s):  
Herpes Simplex ◽  
Blood Cell ◽  
White Blood Cell ◽  
Herpes Simplex Encephalitis ◽  
Pmn Elastase ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Sds Page ◽  
White Blood Cell Counts ◽  
Pmn Élastase

SummaryA 74-year-old female developed pneumonia following herpes simplex encephalitis. Her white blood cell counts reached 28,400/μl, about 90% of which consisted of granulocytes. The polymorphonuclear (PMN) elastase/α1-arantitrypsin complex levels increased and reached the maximum of 5,019 ng/ml, indicating the release of a large amount of elastase derived from the granulocytes. The mechanism of PMN elastase release was most likely to be granulocyte destruction associated with phagocytosis. The cleavage of fibrinogen and fibrin by PMN elastase, independent of plasmin, was indicated by the presence of the fragments in immunoprecipitated plasma from the patient corresponding to elastase-induced FDP D and DD fragments and the absence of fragments corresponding to plasmin-induced FDP D and DD fragments on SDS-PAGE. These findings suggested that the large amount of PMN elastase released from the excessive numbers of granulocytes in this patient with herpes simplex encephalitis and pneumonia, induced the cleavage of fibrinogen and fibrin without the participation of plasmin.

Mediational g-formula for time-varying treatment and repeated-measured multiple mediators: Application to atorvastatin’s effect on cardiovascular disease via cholesterol lowering and anti-inflammatory actions in elderly type 2 diabetics

2021 ◽  
pp. 096228022110259
Author(s):  
Shintaro Yamamuro ◽  
Tomohiro Shinozaki ◽  
Satoshi Iimuro ◽  
Yutaka Matsuyama
Keyword(s):  
Cardiovascular Disease ◽  
Blood Cell ◽  
Indirect Effects ◽  
Time Varying ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Anti Inflammatory ◽  
White Blood Cell Counts ◽  
Inflammatory Action

Modern causal mediation theory has formalized several types of indirect and direct effects of treatment on outcomes regarding specific mediator variables. We reviewed and unified distinct approaches to estimate the “interventional” direct and indirect effects for multiple mediators and time-varying variables. This study was motivated by a clinical trial of elderly type-2 diabetic patients in which atorvastatin was widely prescribed to control patients’ cholesterol levels to reduce diabetic complications, including cardiovascular disease. Among atorvastatin’s preventive side-effects (pleiotropic effects), we focus on its anti-inflammatory action as measured by white blood cell counts. Hence, we estimate atorvastatin’s interventional indirect effects through cholesterol lowering and through anti-inflammatory action, and interventional direct effect bypassing these two actions. In our analysis, total effect (six-year cardiovascular disease risk difference) estimated by standard plug-in g-formula of −3.65% (95% confidence interval: −10.29%, 4.38%) is decomposed into indirect effect via low-density lipoprotein cholesterol (−0.90% [−1.91%, −0.07%]), via white blood cell counts (−0.03% [−0.22%, 0.11%]), and direct effect (−2.84% [−9.71%, 5.41%]) by the proposed parametric mediational g-formula. The SAS program and its evaluation via simulated datasets are provided in the Supplemental materials.

scholarly journals Influence of platelet and white blood cell counts on major thrombosis – analysis from a patient registry in essential thrombocythemia

2016 ◽  
Vol 97 (6) ◽  
pp. 511-516 ◽  
Author(s):  
Veronika Buxhofer‐Ausch ◽  
Michael Steurer ◽  
Siegfried Sormann ◽  
Ernst Schloegl ◽  
Wolfgang Schimetta ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Essential Thrombocythemia ◽  
Patient Registry ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts
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