scholarly journals Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors

2002 ◽  
Vol 99 (20) ◽  
pp. 12963-12968 ◽  
Author(s):  
J. R. Pollack ◽  
T. Sorlie ◽  
C. M. Perou ◽  
C. A. Rees ◽  
S. S. Jeffrey ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Copy Number ◽  
Copy Number Alteration ◽  
Breast Tumors ◽  
Human Breast ◽  
Transcriptional Program ◽  
Dna Copy Number ◽  
Direct Role

scholarly journals Role of Mitochondrial DNA Copy Number Alteration in Human Renal Cell Carcinoma

2016 ◽  
Vol 17 (6) ◽  
pp. 814 ◽  
Author(s):  
Chen-Sung Lin ◽  
Hui-Ting Lee ◽  
Ming-Huei Lee ◽  
Siao-Cian Pan ◽  
Chen-Yeh Ke ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Mitochondrial Dna ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Copy Number ◽  
Copy Number Alteration ◽  
Dna Copy Number ◽  
Human Renal Cell Carcinoma ◽  
Mitochondrial Dna Copy Number

Detection of copy number alteration of MTA1 in human breast cancer

2009 ◽  
Vol 6 (4) ◽  
pp. 245-249
Author(s):  
Mengquan Li ◽  
Jingruo Li ◽  
Mingxun Chen ◽  
Juntao Bao
Keyword(s):  
Breast Cancer ◽  
Copy Number ◽  
Human Breast Cancer ◽  
Copy Number Alteration ◽  
Human Breast

scholarly journals The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

2010 ◽  
Vol 83 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Timothy Wai ◽  
Asangla Ao ◽  
Xiaoyun Zhang ◽  
Daniel Cyr ◽  
Daniel Dufort ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Quantitative analysis of chromosomal CGH in human breast tumors associates copy number abnormalities with p53 status and patient survival

2001 ◽  
Vol 98 (14) ◽  
pp. 7952-7957 ◽  
Author(s):  
A. N. Jain ◽  
K. Chin ◽  
A.-L. Borresen-Dale ◽  
B. K. Erikstein ◽  
P. E. Lonning ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Copy Number ◽  
Patient Survival ◽  
Breast Tumors ◽  
Human Breast ◽  
P53 Status

scholarly journals The RNA-binding protein, Rasputin/G3BP, enhances the stability and translation of its target mRNAs

2020 ◽  
Author(s):  
John D. Laver ◽  
Jimmy Ly ◽  
Allison K. Winn ◽  
Angelo Karaiskakis ◽  
Sichun Lin ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Rna Binding Protein ◽  
Stress Granules ◽  
Direct Role ◽  
Target Mrnas ◽  
Core Components ◽  
The Stability

SUMMARYG3BP RNA-binding proteins are important components of stress granules (SGs). Here we analyze the role of Drosophila G3BP, Rasputin (RIN), in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray analysis identified over 550 mRNAs that copurify with RIN. The mRNAs found in SGs are long and translationally silent. In contrast, we find that RIN-bound mRNAs, which encode core components of the transcription, splicing and translation machinery, are short, stable and highly translated. We show that RIN is associated with polysomes and provide evidence for a direct role for RIN and its human homologs in stabilizing and upregulating the translation of their target mRNAs. We propose that when cells are stressed the resulting incorporation of RIN/G3BPs into SGs sequesters them away from their short target mRNAs. This would downregulate the expression of these transcripts, even though they are not incorporated into stress granules.

scholarly journals Bayesian Circle Segmentation with Application to DNA Copy Number Alteration Detection

2021 ◽  
Vol 6 (1) ◽  
pp. 53-73
Author(s):  
Junfeng Liu ◽  
Harner Harner ◽  
Harry Yang
Keyword(s):  
Copy Number ◽  
Copy Number Alteration ◽  
Dna Copy Number
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