Biodegradable nanofiber-based piezoelectric transducer

Piezoelectric materials, a type of “smart” material that generates electricity while deforming and vice versa, have been used extensively for many important implantable medical devices such as sensors, transducers, and actuators. However, commonly utilized piezoelectric materials are either toxic or nondegradable. Thus, implanted devices employing these materials raise a significant concern in terms of safety issues and often require an invasive removal surgery, which can damage directly interfaced tissues/organs. Here, we present a strategy for materials processing, device assembly, and electronic integration to 1) create biodegradable and biocompatible piezoelectric PLLA [poly(l-lactic acid)] nanofibers with a highly controllable, efficient, and stable piezoelectric performance, and 2) demonstrate device applications of this nanomaterial, including a highly sensitive biodegradable pressure sensor for monitoring vital physiological pressures and a biodegradable ultrasonic transducer for blood–brain barrier opening that can be used to facilitate the delivery of drugs into the brain. These significant applications, which have not been achieved so far by conventional piezoelectric materials and bulk piezoelectric PLLA, demonstrate the PLLA nanofibers as a powerful material platform that offers a profound impact on various medical fields including drug delivery, tissue engineering, and implanted medical devices.

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Wireless Power Transfer to Implantable Medical Devices With Multi-Layer Planar Spiral Coils

Research Anthology on Emerging Technologies and Ethical Implications in Human Enhancement ◽

10.4018/978-1-7998-8050-9.ch023 ◽

2021 ◽

pp. 457-481

Author(s):

N. Sertac Artan ◽

Reza K. Amineh

Keyword(s):

Medical Devices ◽

Wireless Power Transfer ◽

Health Condition ◽

Implantable Cardioverter Defibrillators ◽

Power Transfer ◽

Wireless Power ◽

Implantable Medical Devices ◽

Implanted Medical Devices ◽

Spiral Coils ◽

Cardioverter Defibrillators

Implantable medical devices such as pacemakers, implantable cardioverter defibrillators, deep brain stimulators, retinal and cochlear implants are gaining significant attraction and growth due to their capability to monitor the health condition in real time, diagnose a particular disease, or provide treatment for a particular disease. In order to charge these devices, wireless power transfer technology is considered as a powerful means. This eliminates the need for extra surgery to replace the battery. In this chapter, some of the major implanted medical devices are reviewed. Then, various wireless power transfer configurations are reviewed briefly for charging such devices. The chapter continues with reviewing wireless power transfer configurations based on the multi-layer printed or non-printed planar spiral coils. At the end, some of the recent works related to using multi-layer planar spiral coils for safe and efficient powering of IMDs will be discussed.

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Challenges for the Implantation of Symbiotic Nanostructured Medical Devices

Applied Sciences ◽

10.3390/app10082923 ◽

2020 ◽

Vol 10 (8) ◽

pp. 2923 ◽

Cited By ~ 2

Author(s):

Jean-Pierre Alcaraz ◽

Gauthier Menassol ◽

Géraldine Penven ◽

Jacques Thélu ◽

Sarra El Ichi ◽

...

Keyword(s):

Medical Device ◽

Medical Devices ◽

The Body ◽

Biofuel Cells ◽

Implantable Medical Devices ◽

Enzymatic Biofuel Cells ◽

Starting Point ◽

Implanted Medical Devices ◽

Biomimetic Approach ◽

Implanted Device

We discuss the perspectives of designing implantable medical devices that have the criterion of being symbiotic. Our starting point was whether the implanted device is intended to have any two-way (“duplex”) communication of energy or materials with the body. Such duplex communication extends the existing concepts of a biomaterial and biocompatibility to include the notion that it is important to consider the intended functional use of the implanted medical device. This demands a biomimetic approach to design functional symbiotic implantable medical devices that can be more efficient in mimicking what is happening at the molecular and cellular levels to create stable interfaces that allow for the unfettered exchanges of molecules between an implanted device and a body. Such a duplex level of communication is considered to be a necessary characteristic of symbiotic implanted medical devices that are designed to function for long periods of time inside the body to restore and assist the function of the body. We illustrate these perspectives with experience gained from implanting functional enzymatic biofuel cells.

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Medical device innovations for cardiovascular, ophthalmologic and otolaryngologic applications

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2019-0030 ◽

2019 ◽

Vol 5 (1) ◽

pp. 117-118

Author(s):

Niels Grabow ◽

Volkmar Senz ◽

Klaus-Peter Schmitz

Keyword(s):

Medical Device ◽

Medical Devices ◽

Implantable Medical Devices ◽

Platform Technology ◽

Device Applications ◽

Innovation Processes

AbstractThe consortium RESPONSE is a cooperation between partners from science and industry within the BMBF-Program “Twenty20 - Partnership for Innovation”, 2014-2021. RESPONSE gives its partners opportunities to put medical device innovations into practice more efficiently. In order to accelerate innovation processes, joint efforts are being made along the entire translation chain. RESPONSE is focusing on the development of novel concepts of implantable medical devices for cardiovascular, ophthalmologic and ENT application. Platform technology approaches are being used to extend the range of device applications. See also: www.response.uni-rostock.de

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The Potential Role of Polymethyl Methacrylate as a New Packaging Material for the Implantable Medical Device in the Bladder

BioMed Research International ◽

10.1155/2015/852456 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Su Jin Kim ◽

Bumkyoo Choi ◽

Kang Sup Kim ◽

Woong Jin Bae ◽

Sung Hoo Hong ◽

...

Keyword(s):

Foreign Body ◽

Polymethyl Methacrylate ◽

Inflammatory Cytokines ◽

Medical Devices ◽

Foreign Body Reaction ◽

Early Period ◽

Implantable Medical Device ◽

Implantable Medical Devices ◽

Macrophage Activity ◽

Implanted Medical Devices

Polydimethylsiloxane (PDMS) is used in implantable medical devices; however, PDMS is not a completely biocompatible material for electronic medical devices in the bladder. To identify novel biocompatible materials for intravesical implanted medical devices, we evaluated the biocompatibility of polymethyl methacrylate (PMMA) by analyzing changes in the levels of macrophages, macrophage migratory inhibitory factor (MIF), and inflammatory cytokines in the bladder. A ball-shaped metal coated with PMMA or PDMS was implanted into the bladders of rats, and after intravesical implantation, the inflammatory changes induced by the foreign body reaction were evaluated. In the early period after implantation, increased macrophage activity and MIF in the urothelium of the bladder were observed. However, significantly decreased macrophage activity and MIF in the bladder were observed after implantation with PMMA- or PDMS-coated metal in the later period. In addition, significantly decreased inflammatory cytokines such as IL-1β, IL-6, and TNF-αwere observed with time. Based on these results, we suggest that MIF plays a role in the foreign body reaction and in the biocompatible packaging with PMMA for the implanted medical devices in the bladder.

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In Vitro Models of Biological Responses to Implant Microbiological Models

Advances in Dental Research ◽

10.1177/08959374990130011701 ◽

1999 ◽

Vol 13 (1) ◽

pp. 67-72 ◽

Cited By ~ 15

Author(s):

Andrea Mombelli

Keyword(s):

Medical Devices ◽

Antimicrobial Agents ◽

In Vitro Models ◽

Implantable Medical Devices ◽

Oral Implants ◽

Common Features ◽

Biological Responses ◽

Implanted Medical Devices ◽

Micro Organisms

To study the etiology and explore possibilities for the therapy of implant-associated infections, investigators have developed and utilized various in vitro models. Major contributions have come from the non-oral medical field, where device-related infections can create life-threatening situations. Microbiological models may include (i) models to study the reaction of micro-organisms to the presence of implants, (ii) models to study the reaction of implant-associated micro-organisms to antimicrobial agents, and (iii) models to study the reaction of the host tissues to the presence of implants contaminated with micro-organisms. In evaluating the potential usefulness of these models for research in oral implantology, one must consider common features as well as important differences between implanted medical devices and oral implants. Although infections associated with implantable medical devices and oral peri-implant infections share a remarkable number of common features, there are also important differences that need attention when findings from in vitro experiments are extrapolated to clinical relevance.

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