scholarly journals NTRK2methylation is related to reduced PTSD risk in two African cohorts of trauma survivors

2020 ◽  
Vol 117 (35) ◽  
pp. 21667-21672
Author(s):  
Vanja Vukojevic ◽  
David Coynel ◽  
Navid R. Ghaffari ◽  
Virginie Freytag ◽  
Thomas Elbert ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Memory Performance ◽  
Brain Network ◽  
Network Activity ◽  
Trauma Survivors ◽  
Ptsd Symptoms ◽  
African Populations ◽  
Tropomyosin Related Kinase B ◽  
The Relationship ◽  
With Memory

Extensive pharmacologic, genetic, and epigenetic research has linked the glucocorticoid receptor (GR) to memory processes, and to risk and symptoms of posttraumatic stress disorder (PTSD). In the present study we investigated the epigenetic pattern of 12 genes involved in the regulation of GR signaling in two African populations of heavily traumatized individuals: Survivors of the rebel war in northern Uganda (n= 463) and survivors of the Rwandan genocide (n= 350). The strongest link between regional methylation and PTSD risk and symptoms was observed forNTRK2, which encodes the transmembrane receptor tropomyosin-related kinase B, binds the brain-derived neurotrophic factor, and has been shown to play an important role in memory formation.NTRK2methylation was not related to trauma load, suggesting that methylation differences preexisted the trauma. BecauseNTRK2methylation differences were predominantly associated with memory-related PTSD symptoms, and because they seem to precede traumatic events, we next investigated the relationship betweenNTRK2methylation and memory in a sample of nontraumatized individuals (n= 568). We found thatNTRK2methylation was negatively associated with recognition memory performance. Furthermore, fMRI analyses revealedNTRK2methylation-dependent differences in brain network activity related to recognition memory. The present study demonstrates thatNTRK2is epigenetically linked to memory functions in nontraumatized subjects and to PTSD risk and symptoms in traumatized populations.

scholarly journals Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors

2016 ◽  
Vol 283 (1845) ◽  
pp. 20162275 ◽  
Author(s):  
Shu K. E. Tam ◽  
Sibah Hasan ◽  
Steven Hughes ◽  
Mark W. Hankins ◽  
Russell G. Foster ◽  
...  
Keyword(s):  
Object Recognition ◽  
Recognition Memory ◽  
Ganglion Cells ◽  
Light Exposure ◽  
Memory Performance ◽  
Recognition Task ◽  
Bright Light ◽  
Brain Network ◽  
Network Activity ◽  
Effect Of Light

Acute light exposure exerts various effects on physiology and behaviour. Although the effects of light on brain network activity in humans are well demonstrated, the effects of light on cognitive performance are inconclusive, with the size, as well as direction, of the effect depending on the nature of the task. Similarly, in nocturnal rodents, bright light can either facilitate or disrupt performance depending on the type of task employed. Crucially, it is unclear whether the effects of light on behavioural performance are mediated via the classical image-forming rods and cones or the melanopsin-expressing photosensitive retinal ganglion cells. Here, we investigate the modulatory effects of light on memory performance in mice using the spontaneous object recognition task. Importantly, we examine which photoreceptors are required to mediate the effects of light on memory performance. By using a cross-over design, we show that object recognition memory is disrupted when the test phase is conducted under a bright light (350 lux), regardless of the light level in the sample phase (10 or 350 lux), demonstrating that exposure to a bright light at the time of test, rather than at the time of encoding, impairs performance. Strikingly, the modulatory effect of light on memory performance is completely abolished in both melanopsin-deficient and rodless–coneless mice. Our findings provide direct evidence that melanopsin-driven and rod/cone-driven photoresponses are integrated in order to mediate the effect of light on memory performance.

scholarly journals Memorable words are monogamous: The role of synonymy and homonymy in word recognition memory

2018 ◽  
Author(s):  
Kyle Mahowald ◽  
Phillip Isola ◽  
Evelina Fedorenko ◽  
Edward Gibson ◽  
Aude Oliva
Keyword(s):  
Recognition Memory ◽  
Large Scale ◽  
Recognition Performance ◽  
Memory Performance ◽  
Affect Recognition ◽  
Rational Analysis ◽  
Intended Meaning ◽  
The Relationship ◽  
With Memory

What makes a word memorable? Prior research has identified numerous factors: word frequency, concreteness, imageability, and valence have all been shown to affect recognition performance. One important dimension that has not received much attention is the nature of the relationship between words and meanings. Under the hypothesis that words are encoded primarily by their meanings, and not by their surface forms, this relationship should be central to determining word memorability. In particular, rational analysis suggests that people will more easily remember words that convey a large amount of informationabout their intended meaning and that have few alternatives – that is, memorable words will be those with few possiblemeanings and synonyms. To test this hypothesis, we ran two large-scale recognition memory experiments (each with 2,222 words, 600+ participants). Memory performance was overall high, on par with memory for pictures in a similar paradigm. Critically, however, not all words were remembered equally well. Consistent with our proposal, the best recognized words had few meanings and few synonyms. Indeed, the most memorable words had a one-to-one relationship with their meanings. Estimates of memorability derived from this rational account explain a large amount of the variance in word memorability.

scholarly journals Autonomic activity during sleep predicts memory consolidation in humans

2016 ◽  
Vol 113 (26) ◽  
pp. 7272-7277 ◽  
Author(s):  
Lauren N. Whitehurst ◽  
Nicola Cellini ◽  
Elizabeth A. McDevitt ◽  
Katherine A. Duggan ◽  
Sara C. Mednick
Keyword(s):  
Memory Consolidation ◽  
Memory Performance ◽  
Sleep Stages ◽  
Remote Associates Test ◽  
Daytime Nap ◽  
The Relationship ◽  
With Memory ◽  
Good Sleep ◽  
Variance Explained

Throughout history, psychologists and philosophers have proposed that good sleep benefits memory, yet current studies focusing on the relationship between traditionally reported sleep features (e.g., minutes in sleep stages) and changes in memory performance show contradictory findings. This discrepancy suggests that there are events occurring during sleep that have not yet been considered. The autonomic nervous system (ANS) shows strong variation across sleep stages. Also, increases in ANS activity during waking, as measured by heart rate variability (HRV), have been correlated with memory improvement. However, the role of ANS in sleep-dependent memory consolidation has never been examined. Here, we examined whether changes in cardiac ANS activity (HRV) during a daytime nap were related to performance on two memory conditions (Primed and Repeated) and a nonmemory control condition on the Remote Associates Test. In line with prior studies, we found sleep-dependent improvement in the Primed condition compared with the Quiet Wake control condition. Using regression analyses, we compared the proportion of variance in performance associated with traditionally reported sleep features (model 1) vs. sleep features and HRV during sleep (model 2). For both the Primed and Repeated conditions, model 2 (sleep + HRV) predicted performance significantly better (73% and 58% of variance explained, respectively) compared with model 1 (sleep only, 46% and 26% of variance explained, respectively). These findings present the first evidence, to our knowledge, that ANS activity may be one potential mechanism driving sleep-dependent plasticity.

scholarly journals 0084 Sleep Consolidates Incidentally Encoded Information After Deep but Not Shallow Encoding

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A34-A34
Author(s):  
E M Wernette ◽  
K M Fenn
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Declarative Memory ◽  
Memory Performance ◽  
Memory Test ◽  
Memory Traces ◽  
Incidental Encoding ◽  
The Relationship ◽  
With Memory

Abstract Introduction Slow wave sleep (SWS) strengthens declarative memory for information studied for a later test. However, research on the effect of sleep on information that is not intentionally remembered is scare. Previous research from our lab suggests sleep consolidates some, but not all, information that has been encoded incidentally, meaning that it has been acted on but not intentionally remembered. It remains unclear what determines which information benefits from sleep-dependent consolidation processes and what aspects of sleep are related to these mnemonic benefits. In two experiments, we test the hypothesis that sleep consolidates strong but not weak memory traces following incidental encoding, and assess the relationship between memory performance and objective sleep characteristics. Methods In Experiment 1, participants rated words one (weak traces) or three times (strong traces) in a deep or shallow incidental encoding task. Participants either rated words on a scale from ‘concrete’ to ‘abstract’ (deep) or counted the vowels in the words (shallow). Following a 12-hour period containing sleep or wakefulness, participants took a surprise memory test. In Experiment 2, participants rated words one or three times in the deep encoding task, received an 8-hour sleep opportunity with polysomnography, and took the surprise memory test. Results In Experiment 1, participants remembered words better after sleep than wake regardless of whether words were encoded one or three times, but only after deep encoding. Sleep did not consolidate information following shallow encoding. Experiment 2 is ongoing, but we predict that the amount of SWS will correlate positively with memory. Conclusion Results thus far suggest sleep may have consolidated information based on the strength of memory traces. Because deep encoding results in stronger memory traces than shallow encoding, this work is broadly consistent with theories of memory consolidation that predict sleep is more beneficial for strong memory traces than weak, such as the synaptic downscaling hypothesis. Support N/A

Cultural Variations in Resilience Capacity and Posttraumatic Stress: A Tri-Cultural Comparison

2019 ◽  
Vol 54 (2-3) ◽  
pp. 273-295
Author(s):  
Ping Zheng ◽  
Matt J. Gray ◽  
Wen-Jie Duan ◽  
Samuel M. Y. Ho ◽  
Mian Xia ◽  
...  
Keyword(s):  
Hong Kong ◽  
Posttraumatic Stress ◽  
Mainland China ◽  
Psychological Trauma ◽  
Trauma Survivors ◽  
Ptsd Symptoms ◽  
Cultural Variations ◽  
Resilience Scale ◽  
The Relationship ◽  
Resilience Capacity

Resilience capacity has been associated with individuals’ flexibility and adaptability in responding to potential trauma. Culture-related appraisals influence not only interpretations of etiology of posttraumatic stress disorder (PTSD) and perception of severity of PTSD symptoms but also flexible coping strategies. However, adequate research of the mechanisms on how culture may affect the relationship between resilience and PTSD does not yet exist. The present study focused on whether and how culture (America, Hong Kong, and Mainland China) moderated the relationship between resilience capacity and severity of posttraumatic distress. Data were collected at three research sites (America, Hong Kong, and Mainland China) where 558 trauma survivors were recruited. Measures included the Life Events Checklist ( LEC-5), the PTSD Checklist for DSM-5 ( PCL-5), and the Revised Connor-Davidson Resilience Scale ( CD-RISC-R). The results of one-way analysis of variance (ANOVA) indicated that American participants were more resilient than the participants in Hong Kong and Mainland China. The results of multiple regression indicated that frequency of exposure to trauma was a weaker predictor of severity of PTSD symptoms at high versus low levels of resilience capacity. The results also indicated a weaker moderating effect of Hong Kong versus American culture on the relation between resilience capacity and PTSD. This pilot study highlighted East–West cultural differences in the baselines of resilience capacity and posttraumatic stress and may motivate clinicians and researchers to reevaluate Western diagnostic criteria to psychological trauma conceptualization and treatment for non-Western populations.

scholarly journals Load Modulation of BOLD Response and Connectivity Predicts Working Memory Performance in Younger and Older Adults

2011 ◽  
Vol 23 (8) ◽  
pp. 2030-2045 ◽  
Author(s):  
Irene E. Nagel ◽  
Claudia Preuschhof ◽  
Shu-Chen Li ◽  
Lars Nyberg ◽  
Lars Bäckman ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Individual Differences ◽  
Imaging Techniques ◽  
Memory Performance ◽  
Premotor Cortex ◽  
Brain Network ◽  
Network Activity ◽  
Adult Age ◽  
Dorsolateral Prefrontal

Individual differences in working memory (WM) performance have rarely been related to individual differences in the functional responsivity of the WM brain network. By neglecting person-to-person variation, comparisons of network activity between younger and older adults using functional imaging techniques often confound differences in activity with age trends in WM performance. Using functional magnetic resonance imaging, we investigated the relations among WM performance, neural activity in the WM network, and adult age using a parametric letter n-back task in 30 younger adults (21–31 years) and 30 older adults (60–71 years). Individual differences in the WM network's responsivity to increasing task difficulty were related to WM performance, with a more responsive BOLD signal predicting greater WM proficiency. Furthermore, individuals with higher WM performance showed greater change in connectivity between left dorsolateral prefrontal cortex and left premotor cortex across load. We conclude that a more responsive WM network contributes to higher WM performance, regardless of adult age. Our results support the notion that individual differences in WM performance are important to consider when studying the WM network, particularly in age-comparative studies.

scholarly journals Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study

2017 ◽  
Vol 46 (1) ◽  
pp. 392-402 ◽  
Author(s):  
Gang Tan ◽  
Zeng-Renqing Dan ◽  
Ying Zhang ◽  
Xin Huang ◽  
Yu-Lin Zhong ◽  
...  
Keyword(s):  
Brain Activity ◽  
Superior Temporal Gyrus ◽  
Brain Regions ◽  
Brain Network ◽  
Network Activity ◽  
Ocular Motility ◽  
Behavioral Performance ◽  
Parietal Lobule ◽  
The Right ◽  
The Relationship

Objective To investigate the underlying functional network brain-activity changes in patients with adult comitant exotropia strabismus (CES) and the relationship with clinical features using the voxel-wise degree centrality (DC) method. Methods A total of 30 patients with CES (17 men, 13 women), and 30 healthy controls (HCs; 17 men, 13 women) matched in age, sex, and education level participated in the study. DC was used to evaluate spontaneous brain activity. Receiver operating characteristic (ROC) curve analysis was conducted to distinguish CESs from HCs. The relationship between mean DC values in various brain regions and behavioral performance was examined with correlation analysis. Results Compared with HCs, CES patients exhibited decreased DC values in the right cerebellum posterior lobe, right inferior frontal gyrus, right middle frontal gyrus and right superior parietal lobule/primary somatosensory cortex (S1), and increased DC values in the right superior temporal gyrus, bilateral anterior cingulate, right superior temporal gyrus, and left inferior parietal lobule. However, there was no correlation between mean DC values and behavioral performance in any brain regions. Conclusions Adult comitant exotropia strabismus is associated with abnormal brain network activity in various brain regions, possibly reflecting the pathological mechanisms of ocular motility disorders in CES.

scholarly journals Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers

Neurology ◽  
2017 ◽  
Vol 89 (17) ◽  
pp. 1782-1788 ◽  
Author(s):  
Kaitlin B. Casaletto ◽  
Fanny M. Elahi ◽  
Brianne M. Bettcher ◽  
John Neuhaus ◽  
Barbara B. Bendlin ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Aging ◽  
Brain Aging ◽  
Memory Performance ◽  
Verbal Learning ◽  
Delayed Recall ◽  
Age Related ◽  
T Tau ◽  
The Relationship ◽  
With Memory

Objective:To determine the association between synaptic functioning as measured via neurogranin in CSF and cognition relative to established Alzheimer disease (AD) biomarkers in neurologically healthy older adults.Methods:We analyzed CSF concentrations of neurogranin, β-amyloid (Aβ42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55–85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall). Univariable analyses examined the relationship between neurogranin and the other AD-related biomarkers. Multivariable regression models examined the relationship between neurogranin and delayed recall, adjusting for age and sex, and interaction terms (neurogranin × AD biomarkers).Results:Higher neurogranin concentrations were associated with older age (ρ = 0.20, p = 0.02), lower levels of p-tau and t-tau, and smaller hippocampal volumes (p < 0.03), but not with CSF Aβ42 (p = 0.18). In addition, CSF neurogranin demonstrated a significant relationship with memory performance independent of the AD-related biomarkers; individuals with the lowest CSF neurogranin concentrations performed better on delayed recall than those with medium or high CSF neurogranin concentrations (p < 0.01). Notably, CSF p-tau, t-tau, and Aβ42 and hippocampal volumes were not significantly associated with delayed recall scores (p > 0.40), and did not interact with neurogranin to predict memory (p > 0.10).Conclusions:Synaptic dysfunction (assessed via neurogranin) may be an early pathologic process in age-related neurodegeneration, and a sensitive marker of age-related cognitive abilities, potentially preceding or even acting independently from AD pathogenesis. Synaptic functioning may be a useful early marker of cognitive aging and possibly a target for future brain aging interventions.

scholarly journals Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse

2021 ◽  
Vol 2 ◽  
Author(s):  
Alina C. Stimmell ◽  
Zishen Xu ◽  
Shawn C. Moseley ◽  
Sarah D. Benthem ◽  
Diana M. Fernandez ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Performance ◽  
Brain Network ◽  
Spatial Learning And Memory ◽  
Tau Pathology ◽  
Spatial Disorientation ◽  
Spatial Reorientation ◽  
Hippocampal Network ◽  
The Relationship

In early Alzheimer's disease (AD) spatial navigation is one of the first impairments to emerge; however, the precise cause of this impairment is unclear. Previously, we showed that, in a mouse model of tau and amyloid beta (Aβ) aggregation, getting lost represents, at least in part, a failure to use distal cues to get oriented in space and that impaired parietal-hippocampal network level plasticity during sleep may underlie this spatial disorientation. However, the relationship between tau and amyloid beta aggregation in this brain network and impaired spatial orientation has not been assessed. Therefore, we used several approaches, including canonical correlation analysis and independent components analysis tools, to examine the relationship between pathology profile across the parietal-hippocampal brain network and spatial reorientation learning and memory performance. We found that consistent with the exclusive impairment in 3xTg-AD 6-month female mice, only 6-month female mice had an ICA identified pattern of tau pathology across the parietal-hippocampal network that were positively correlated with behavior. Specifically, a higher density of pTau positive cells predicted worse spatial learning and memory. Surprisingly, despite a lack of impairment relative to controls, 3-month female, as well as 6- and 12- month male mice all had patterns of tau pathology across the parietal-hippocampal brain network that are predictive of spatial learning and memory performance. However, the direction of the effect was opposite, a negative correlation, meaning that a higher density of pTau positive cells predicted better performance. Finally, there were not significant group or region differences in M78 density at any of the ages examined and ICA analyses were not able to identify any patterns of 6E10 staining across brain regions that were significant predictors of behavioral performance. Thus, the pattern of pTau staining across the parietal-hippocampal network is a strong predictor of spatial learning and memory performance, even for mice with low levels of tau accumulation and intact spatial re-orientation learning and memory. This suggests that AD may cause spatial disorientation as a result of early tau accumulation in the parietal-hippocampal network.

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