scholarly journals Carbonic anhydrase C in the neural retina: transition from generalized to glia-specific cell localization during embryonic development.

1981 ◽  
Vol 78 (11) ◽  
pp. 7190-7194 ◽  
Author(s):  
P. Linser ◽  
A. A. Moscona
Keyword(s):  
Carbonic Anhydrase ◽  
Embryonic Development ◽  
Neural Retina ◽  
Specific Cell ◽  
Cell Localization

scholarly journals Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues

2009 ◽  
Vol 9 (5) ◽  
pp. 314-323 ◽  
Author(s):  
Daniel R. McCulloch ◽  
Carine Le Goff ◽  
Sumantha Bhatt ◽  
Laura J. Dixon ◽  
John D. Sandy ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Specific Cell ◽  
Gene Encoding ◽  
Cell Lineages ◽  
Adult Tissues

Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup

Development ◽  
1999 ◽  
Vol 126 (8) ◽  
pp. 1753-1768 ◽  
Author(s):  
M.J. Solloway ◽  
E.J. Robertson
Keyword(s):  
Embryonic Development ◽  
Double Mutant ◽  
Structure And Function ◽  
Bmp Signaling ◽  
Cell Populations ◽  
Specific Cell ◽  
Early Embryonic Lethality ◽  
Branchial Arches ◽  
High Conservation ◽  
And Function

Members of the BMP family of signaling molecules display a high conservation of structure and function, and multiple BMPs are often coexpressed in a variety of tissues during development. Moreover, distinct BMP ligands are capable of activating common pathways. Here we describe the coexpression of two members of the 60A subfamily of BMPs, Bmp5 and Bmp7, at a number of different sites in the embryo from gastrulation onwards. Previous studies demonstrate that loss of either Bmp5 or Bmp7 has negligible effects on development, suggesting these molecules functionally compensate for each other at early stages of embryonic development. Here we show this is indeed the case. Thus we find that Bmp5;Bmp7 double mutants die at 10.5 dpc and display striking defects primarily affecting the tissues where these factors are coexpressed. The present analysis also uncovers novel roles for BMP signaling during the development of the allantois, heart, branchial arches, somites and forebrain. Bmp5 and Bmp7 do not appear to be involved in establishing pattern in these tissues, but are instead necessary for the proliferation and maintenance of specific cell populations. These findings are discussed with respect to potential mechanisms underlying cooperative signaling by multiple members of the TGF-beta superfamily.

Calcium mobilization from the avian eggshell during embryonic development

2013 ◽  
Vol 63 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Ola Österström ◽  
Lena Holm ◽  
Clas Lilja
Keyword(s):  
Carbonic Anhydrase ◽  
Embryonic Development ◽  
Enzyme Histochemistry ◽  
Chorioallantoic Membrane ◽  
Bird Species ◽  
Sturnus Vulgaris ◽  
Calcium Mobilization ◽  
Coturnix Japonica ◽  
Before And After

The avian eggshell acts as the major source of calcium for embryogenesis in bird. Using scanning electron microscopy, the inner eggshell surface was analysed before and after embryonic development and its accompanying calcium removal. This was done in eggs from two bird species with different growth rates and modes of development, the precocial Japanese quail Coturnix japonica and the altricial starling Sturnus vulgaris. Next, enzyme histochemistry was used to localize carbonic anhydrase in the extra-embryonic chorioallantoic membrane to provide support for the hypothesis that calcium may be released from the eggshell by means of acidification through the action of carbonic anhydrase. However, neither in the precocial quail nor in the altricial starling could any staining for carbonic anhydrase be detected. These results lead us to the conclusion that the role of carbonic anhydrase in embryonic calcium mobilization from the avian eggshell remains unclear.

scholarly journals An Association between Mitochondria and the Endoplasmic Reticulum in Cells of the Pseudobranch Gland of a Teleost

1959 ◽  
Vol 5 (3) ◽  
pp. 393-396 ◽  
Author(s):  
D. E. Copeland ◽  
A. J. Dalton
Keyword(s):  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Plasma Membrane ◽  
Carbonic Anhydrase ◽  
Basement Membrane ◽  
The Other ◽  
Secretory Cells ◽  
Specific Cell ◽  
Primary Products ◽  
In Cells

An elaborate and apparently unique specialization of the endoplasmic reticulum having the form of tubules and a precise orientation with respect to the mitochondria has been described for the specific cell of the pseudobranch gland. The tubules also are concentrated near the vascular border of the cell where they show continuity with the plasma membrane and open directly against the basement membrane. On the other side of the basement membrane, the endothelial cells of the sinusoid show openings or discontinuities characteristically associated with secretory cells. The pseudobranch gland is presumed to have carbonic anhydrase as one of its primary products, if not its only one, and the elaborate ultrastructure is thought to be associated with the special problems of secreting this enzyme.

scholarly journals Overlapping and non-overlapping roles of the class-I histone deacetylase-1 corepressors LET-418, SIN-3, and SPR-1 in Caenorhabditis elegans embryonic development

2021 ◽  
Author(s):  
Yukihiro Kubota ◽  
Yuto Ohnishi ◽  
Tasuku Hamasaki ◽  
Gen Yasui ◽  
Natsumi Ota ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Embryonic Development ◽  
Histone Deacetylase ◽  
Genetic Interactions ◽  
Class I ◽  
Specific Cell ◽  
Nucleosome Remodeling ◽  
Expression Levels ◽  
C Elegans ◽  
Functional Relationships

AbstractBackgroundHistone deacetylase (HDAC)-1, a Class-I HDAC family member, forms three types of complexes, the nucleosome remodeling deacetylase, Sin3, and CoREST complexes with the specific corepressor components chromodomain-helicase-DNA-binding protein 3 (Mi2/CHD-3), Sin3, and REST corepressor 1 (RCOR1), respectively, in humans.ObjectiveTo elucidate the functional relationships among the three transcriptional corepressors during embryogenesis.MethodsThe activities of HDA-1, LET-418, SIN-3, and SPR-1, the homologs of HDAC-1, Mi2, Sin3, and RCOR1 inCaenorhabditis elegansduring embryogenesis were investigated through measurement of relative mRNA expression levels and embryonic lethality given either gene knockdown or deletion. Additionally, the terminal phenotypes of each knockdown and mutant embryo were observed using a differential-interference contrast microscope. Finally, the functional relationships among the three corepressors were examined through genetic interactions and transcriptome analyses.ResultsHere, we report that each of the corepressors LET-418, SIN-3, and SPR-1 are expressed and have essential roles inC. elegansembryonic development. Our terminal phenotype observations of single mutants further implied that LET-418, SIN-3, and SPR-1 play similar roles in promoting advancement to the middle and late embryonic stages. Combined analysis of genetic interactions and gene ontology of these corepressors indicate a prominent overlapping role among SIN-3, SPR-1, and LET-418 and between SIN-3 and SPR-1.ConclusionOur findings suggest that the class-I HDAC-1 corepressors LET-418, SIN-3, and SPR-1 may cooperatively regulate the expression levels of some genes duringC. elegansembryogenesis or may have some similar roles but functioning independently within a specific cell.

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