scholarly journals Mouse T Cell Membrane Proteins Rt61 and Rt62 Are Arginine/Protein Mono(ADPribosyl)transferases and Share Secondary Structure Motifs with ADP-ribosylating Bacterial Toxins

1996 ◽  
Vol 271 (13) ◽  
pp. 7686-7693 ◽  
Author(s):  
Friedrich Koch-Nolte ◽  
David Petersen ◽  
Sriram Balasubramanian ◽  
Friedrich Haag ◽  
Dominik Kahlke ◽  
...  
Keyword(s):  
T Cell ◽  
Secondary Structure ◽  
Membrane Proteins ◽  
Cell Membrane ◽  
Bacterial Toxins ◽  
Cell Membrane Proteins ◽  
T Cell Membrane

High resolution differential membrane protein analysis of scarce samples – Analysis of T cell membrane proteins

2005 ◽  
Vol 2005 (Fall) ◽  
Author(s):  
Katrin Marcus ◽  
Stefan Helling ◽  
Edgar Schmidt ◽  
Cornelia Joppich ◽  
Thomas Schulenborg ◽  
...  
Keyword(s):  
T Cell ◽  
High Resolution ◽  
Membrane Proteins ◽  
Cell Membrane ◽  
Membrane Protein ◽  
Protein Analysis ◽  
Cell Membrane Proteins ◽  
T Cell Membrane

Differential analysis of T cell membrane proteins

2004 ◽  
Vol 2004 (Fall) ◽  
Author(s):  
Stefan Helling ◽  
Petra Lutter ◽  
Petra Weingarten ◽  
Christoph H�ls ◽  
Helmut Jonuleit ◽  
...  
Keyword(s):  
T Cell ◽  
Membrane Proteins ◽  
Cell Membrane ◽  
Differential Analysis ◽  
Cell Membrane Proteins ◽  
T Cell Membrane

Uncovered: the family relationship of a T-cell-membrane protein and bacterial toxins

1996 ◽  
Vol 17 (9) ◽  
pp. 402-405 ◽  
Author(s):  
Friedrieh Koch-Nolte ◽  
Friedrich Haag ◽  
Robert Kastelein ◽  
Fernando Bazan
Keyword(s):  
T Cell ◽  
Cell Membrane ◽  
Membrane Protein ◽  
Family Relationship ◽  
Bacterial Toxins ◽  
The Family ◽  
Cell Membrane Protein ◽  
Relationship Of ◽  
T Cell Membrane

scholarly journals Novel autoantibodies against muscle-cell membrane proteins in patients with myositis

1996 ◽  
Vol 39 (11) ◽  
pp. 1860-1868 ◽  
Author(s):  
Bruno Stuhlmüller ◽  
Ricardo Jerez ◽  
Gert Hausdorf ◽  
Hans-R. Barthel ◽  
Michael Meurer ◽  
...  
Keyword(s):  
Membrane Proteins ◽  
Cell Membrane ◽  
Muscle Cell ◽  
Cell Membrane Proteins ◽  
Muscle Cell Membrane

scholarly journals Identification of novel therapeutic targets for histone 3 mutated children’s brain tumour, using unique tumour cell surface proteomic signatures

2021 ◽  
Vol 23 (Supplement_4) ◽  
pp. iv9-iv9
Author(s):  
Anya Snary ◽  
Richard Grundy ◽  
Rob Layfield ◽  
Ruman Rahman ◽  
Farhana Haque
Keyword(s):  
Membrane Proteins ◽  
Cell Membrane ◽  
Cell Surface ◽  
Brain Tumours ◽  
Expression Patterns ◽  
Surface Membrane ◽  
Therapeutic Targets ◽  
Molecular Signature ◽  
Histone 3 ◽  
Cell Membrane Proteins

Abstract Aims Improvements in the treatments for childhood and adolescent brain tumours, High-Grade Glioma (pHGG) and Diffuse Intrinsic Pontine Glioblastoma (DIPG), have not advanced much and they continue to carry a very poor prognosis. These brain tumours are now defined by mutations affecting histone 3 proteins, indeed 80% of DIPGs harbour histone H3.1 and H3.3 K27M somatic mutations whilst 30% of pHGGs exhibit H3.3 G34R or G34V mutations. We hypothesized that the histone 3 mutant tumours will have distinct mutation specific surfactome (cell membrane proteins) signature. Method We therefore analysed the cell surface proteomics of pHGG and DIPG, in order to identify novel targets for therapy. We have at first isolated the cell membrane fractions from a range of patient cells carrying different histone 3 mutations (G34R, G34V), relative to wild type histone 3. A comparative quantitative mass-spectrometry analyses of these cell surface membrane fractions is then performed. Results The results obtained to date demonstrated unique differential cell membrane expression patterns which correlated to specific mutation type. For example, increased expression of Ras-related proteins Rab-3, Rab-3D is detected only in histone H3.3-G34R mutated cell line in comparison. Conclusion Identification and analyses of these unique cell membrane proteins’ association with specific in H3.3 mutation in pHGG, will help to identify precise mutation specific therapeutic targets, benefiting the patients to receive therapy based on tumour’s molecular signature.

A mineralization strategy based on T-cell membrane coated CaCO3 nanoparticles against breast cancer and metastasis

2021 ◽  
Author(s):  
Yanhua Li ◽  
Xia Zhang ◽  
Xiaohan Liu ◽  
Wei Pan ◽  
Na Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
T Cell ◽  
Cell Membrane ◽  
Cancer Metastasis ◽  
Caco3 Nanoparticles ◽  
T Cell Membrane ◽  
Limited Diffusion

Chemotherapy is always ineffective against cancer metastasis due to the limited diffusion ability of passive agents into the internal tumor. Herein, we designed a mineralization strategy based on the multifunctional...

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