scholarly journals Localization of the Binding Site for Transforming Growth Factor-β in Human α2-Macroglobulin to a 20-kDa Peptide That Also Contains the Bait Region

1998 ◽  
Vol 273 (21) ◽  
pp. 13339-13346 ◽  
Author(s):  
Donna J. Webb ◽  
Janice Wen ◽  
Larry R. Karns ◽  
Michael G. Kurilla ◽  
Steven L. Gonias
Keyword(s):  
Growth Factor ◽  
Binding Site ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Bait Region ◽  
Α2 Macroglobulin

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

Cell ◽  
1988 ◽  
Vol 52 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Pellegrino Rossi ◽  
Gerard Karsenty ◽  
Anita B. Roberts ◽  
Nanette S. Roche ◽  
Michael B. Sporn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Site ◽  
Transcriptional Activation ◽  
Type I Collagen ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Type I ◽  
Nuclear Factor ◽  
Nuclear Factor 1 ◽  
Collagen Promoter

scholarly journals Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

1999 ◽  
Vol 19 (3) ◽  
pp. 1821-1830 ◽  
Author(s):  
Carolyn Wong ◽  
Elissa M. Rougier-Chapman ◽  
Joshua P. Frederick ◽  
Michael B. Datto ◽  
Nicole T. Liberati ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Binding Site ◽  
Transcriptional Activation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
The Other ◽  
Promoter Activation ◽  
Complex Process ◽  
Transcription Factor Complex

ABSTRACT Transcriptional regulation by transforming growth factor β (TGF-β) is a complex process which is likely to involve cross talk between different DNA responsive elements and transcription factors to achieve maximal promoter activation and specificity. Here, we describe a concurrent requirement for two discrete responsive elements in the regulation of the c-Jun promoter, one a binding site for a Smad3-Smad4 complex and the other an AP-1 binding site. The two elements are located 120 bp apart in the proximal c-Jun promoter, and each was able to independently bind its corresponding transcription factor complex. The effects of independently mutating each of these elements were nonadditive; disruption of either sequence resulted in complete or severe reductions in TGF-β responsiveness. This simultaneous requirement for two distinct and independent DNA binding elements suggests that Smad and AP-1 complexes function synergistically to mediate TGF-β-induced transcriptional activation of the c-Jun promoter.

Mutational Analysis of a Transforming Growth Factor-β Receptor Binding Site

1998 ◽  
Vol 15 (3) ◽  
pp. 231-242 ◽  
Author(s):  
James K. Burmester ◽  
Su Wen Qian ◽  
Dennis Ohlsen ◽  
Sonja Phan ◽  
Michael B. Sporn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Binding Site ◽  
Receptor Binding ◽  
Transforming Growth Factor ◽  
Mutational Analysis ◽  
Transforming Growth Factor Β ◽  
Receptor Binding Site ◽  
Β Receptor

scholarly journals Transforming growth factor-β-induced collagen synthesis by human liver myofibroblasts is inhibited by α2-macroglobulin

1997 ◽  
Vol 26 (6) ◽  
pp. 1220-1228 ◽  
Author(s):  
Anke M.B.C. Tiggelman ◽  
Christiaan Linthorst ◽  
Willem Boers ◽  
Henk S. Brand ◽  
Robert A.F.M. Chamuleau
Keyword(s):  
Growth Factor ◽  
Human Liver ◽  
Collagen Synthesis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Liver Myofibroblasts ◽  
Α2 Macroglobulin
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