Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m104436200 ◽

2001 ◽

Vol 276 (48) ◽

pp. 45456-45461 ◽

Author(s):

Andrew S. Greenberg ◽

Wen-Jun Shen ◽

Kizito Muliro ◽

Shailja Patel ◽

Sandra C. Souza ◽

...

Keyword(s):

Hormone Sensitive Lipase ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Hormone Sensitive ◽

Kinase Pathway ◽

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Stimulation of Extracellular Signal-Regulated Kinase Pathway by Suramin with Concomitant Activation of DNA Synthesis in Cultured Cells

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.103.058230 ◽

2003 ◽

Vol 308 (2) ◽

pp. 744-753 ◽

Author(s):

Hiroyasu Nakata

Keyword(s):

Dna Synthesis ◽

Cultured Cells ◽

Extracellular Signal Regulated Kinase ◽

Activation Of Dna Synthesis ◽

Extracellular Signal ◽

Kinase Pathway ◽

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Sustained Activation of the Extracellular Signal-regulated Kinase Pathway Is Required for Extracellular Calcium Stimulation of Human Osteoblast Proliferation

Journal of Biological Chemistry ◽

10.1074/jbc.m010921200 ◽

2001 ◽

Vol 276 (24) ◽

pp. 21351-21358 ◽

Author(s):

Zhengmin Huang ◽

Su-Li Cheng ◽

Eduardo Slatopolsky

Keyword(s):

Extracellular Calcium ◽

Human Osteoblast ◽

Osteoblast Proliferation ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Calcium Stimulation ◽

Kinase Pathway ◽

Stimulation Of ◽

Sustained Activation

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Disruption of integrin α5β1 signaling does not impair PDGF-BB-mediated stimulation of the extracellular signal-regulated kinase pathway in smooth muscle cells

Journal of Cellular Physiology ◽

10.1002/(sici)1097-4652(199707)172:1<109::aid-jcp12>3.0.co;2-7 ◽

1997 ◽

Vol 172 (1) ◽

pp. 109-116 ◽

Author(s):

Ulf Hedin ◽

Günter Daum ◽

Alexander W. Clowes

Keyword(s):

Smooth Muscle ◽

Smooth Muscle Cells ◽

Muscle Cells ◽

Integrin Α5β1 ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase Pathway ◽

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Stimulation of cultured colon 26 cells with TNF-α promotes lung metastasis through the extracellular signal-regulated kinase pathway

Cancer Letters ◽

10.1016/j.canlet.2004.12.027 ◽

2005 ◽

Vol 230 (1) ◽

pp. 47-56 ◽

Author(s):

Min-Kyung Choo ◽

Hiroaki Sakurai ◽

Keiichi Koizumi ◽

Ikuo Saiki

Keyword(s):

Lung Metastasis ◽

Extracellular Signal Regulated Kinase ◽

Colon 26 ◽

Extracellular Signal ◽

Tnf Α ◽

Kinase Pathway ◽

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Stimulation of Smad1 Transcriptional Activity by Ras-Extracellular Signal-Regulated Kinase Pathway: A Possible Mechanism for Collagen-Dependent Osteoblastic Differentiation

Journal of Bone and Mineral Research ◽

10.1359/jbmr.2002.17.2.240 ◽

2002 ◽

Vol 17 (2) ◽

pp. 240-248 ◽

Author(s):

Miyuki Suzawa ◽

Yasuhiro Tamura ◽

Seiji Fukumoto ◽

Kohei Miyazono ◽

Toshiro Fujita ◽

...

Keyword(s):

Transcriptional Activity ◽

Osteoblastic Differentiation ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Kinase Pathway ◽

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Effects of Stimulation of AMP-activated Protein Kinase on Insulin-like Growth Factor 1- and Epidermal Growth Factor-dependent Extracellular Signal-regulated Kinase Pathway

Journal of Biological Chemistry ◽

10.1074/jbc.m011579200 ◽

2001 ◽

Vol 276 (22) ◽

pp. 19102-19110 ◽

Author(s):

Joungmok Kim ◽

Moon-Young Yoon ◽

Sang-Lim Choi ◽

Insug Kang ◽

Sung-Soo Kim ◽

...

Keyword(s):

Growth Factor ◽

Protein Kinase ◽

Epidermal Growth Factor ◽

Insulin Like Growth Factor ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Epidermal Growth ◽

Amp Activated Protein Kinase ◽

Kinase Pathway ◽

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Regulation of Autophagic Activation by Rta of Epstein-Barr Virus via the Extracellular Signal-Regulated Kinase Pathway

Journal of Virology ◽

10.1128/jvi.02033-14 ◽

2014 ◽

Vol 88 (20) ◽

pp. 12133-12145 ◽

Author(s):

C.-H. Hung ◽

L.-W. Chen ◽

W.-H. Wang ◽

P.-J. Chang ◽

Y.-F. Chiu ◽

...

Keyword(s):

Epstein Barr Virus ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Epstein Barr ◽

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Blockade of the Extracellular Signal-Regulated Kinase Pathway Enhances the Therapeutic Efficacy of Microtubule-Destabilizing Agents in Human Tumor Xenograft Models

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-09-2482 ◽

2010 ◽

Vol 16 (4) ◽

pp. 1170-1178 ◽

Author(s):

K. Watanabe ◽

S. Tanimura ◽

A. Uchiyama ◽

T. Sakamoto ◽

T. Kawabata ◽

...

Keyword(s):

Therapeutic Efficacy ◽

Human Tumor ◽

Tumor Xenograft ◽

Human Tumor Xenograft ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Xenograft Models ◽

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Possible Role of Extracellular Signal-Regulated Kinase Pathway in Regulation of Sox9 mRNA Expression in Chondrocytes under Hydrostatic Pressure

Journal of Bioscience and Bioengineering ◽

10.1263/jbb.104.506 ◽

2007 ◽

Vol 104 (6) ◽

pp. 506-509 ◽

Author(s):

Kensuke Mio ◽

Jennifer Kirkham ◽

William A. Bonass

Keyword(s):

Hydrostatic Pressure ◽

Mrna Expression ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

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Senkyunolide I Relieves Neuropathic Pain Induced by Chronic Constriction Injury by Inhibiting Activation of Microglia

Current Topics in Nutraceutical Research ◽

10.37290/ctnr2641-452x.20:253-258 ◽

2021 ◽

Vol 20 (2) ◽

pp. 253-258

Author(s):

Xiaomin Huang ◽

Miao Huo

Keyword(s):

Neuropathic Pain ◽

Chronic Constriction Injury ◽

Biological Activities ◽

Bioactive Components ◽

Extracellular Signal Regulated Kinase ◽

Extracellular Signal ◽

Induced Apoptosis ◽

Kinase Pathway ◽

As an alternative to the use of narcotics, generally refractory to long-term effectiveness, for the management of neuropathic pain, we have explored the utility of senkyunolide I. Senkyunolide I is one of the bioactive components isolated from Ligusticum chuanxiong Hort known to exhibit multiple biological activities. In this study, we report senkyunolide I inhibition of chronic constriction injury induced neuropathic pain. Mechanistically, senkyunolide I inhibited chronic constriction injury induced apoptosis and the activity of microglia via extracellular signal regulated kinase pathway. We therefore suggest that senkyunolide I could serve as a promising drug for the treatment of neuropathic pain.

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