Possible Role of Extracellular Signal-Regulated Kinase Pathway in Regulation of Sox9 mRNA Expression in Chondrocytes under Hydrostatic Pressure

2007 ◽  
Vol 104 (6) ◽  
pp. 506-509 ◽  
Author(s):  
Kensuke Mio ◽  
Jennifer Kirkham ◽  
William A. Bonass
Keyword(s):  
Hydrostatic Pressure ◽  
Mrna Expression ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Kinase Pathway

scholarly journals Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

2000 ◽  
Vol 351 (2) ◽  
pp. 289-305 ◽  
Author(s):  
Walter KOLCH
Keyword(s):  
Protein Interactions ◽  
Mitogen Activated Protein Kinase ◽  
Protein Protein Interactions ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Substrate Phosphorylation ◽  
Meaningful Relationships ◽  
Kinase Pathway

The Ras/Raf/MEK (mitogen-activated protein kinase/ERK kinase)/ERK (extracellular-signal-regulated kinase) pathway is at the heart of signalling networks that govern proliferation, differentiation and cell survival. Although the basic regulatory steps have been elucidated, many features of this pathway are only beginning to emerge. This review focuses on the role of protein–protein interactions in the regulation of this pathway, and how they contribute to co-ordinate activation steps, subcellular redistribution, substrate phosphorylation and cross-talk with other signalling pathways.

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