Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

Elke Prade; Heiko J. Bittner; Riddhiman Sarkar; Juan Miguel Lopez del Amo; Gerhard Althoff-Ospelt; Gerd Multhaup; Peter W. Hildebrand; Bernd Reif

doi:10.1074/jbc.m115.675215

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

Journal of Biological Chemistry ◽

10.1074/jbc.m115.675215 ◽

2015 ◽

Vol 290 (48) ◽

pp. 28737-28745 ◽

Cited By ~ 17

Author(s):

Elke Prade ◽

Heiko J. Bittner ◽

Riddhiman Sarkar ◽

Juan Miguel Lopez del Amo ◽

Gerhard Althoff-Ospelt ◽

...

Keyword(s):

Alzheimer Disease ◽

Structural Mechanism ◽

Inflammatory Drug ◽

Sulindac Sulfide ◽

Anti Inflammatory ◽

Aβ Fibrils

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Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti-inflammatory Prevention Trial

International Journal of Geriatric Psychiatry ◽

10.1002/gps.2723 ◽

2011 ◽

pp. n/a-n/a ◽

Cited By ~ 16

Author(s):

Jeannie-Marie S. Leoutsakos ◽

Bengt O. Muthen ◽

John C.S. Breitner ◽

Constantine G. Lyketsos ◽

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Alzheimer Disease ◽

Cognitive Decline ◽

Prevention Trial ◽

Inflammatory Drug ◽

Randomized Controlled ◽

Drug Treatments ◽

Anti Inflammatory

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The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-04-0201 ◽

2005 ◽

Vol 4 (3) ◽

pp. 487-493

Author(s):

Jong-Sik Kim ◽

Seung Joon Baek ◽

Tina Sali ◽

Thomas E. Eling

Keyword(s):

Ovarian Cancer ◽

Cell Growth ◽

Cancer Cell ◽

Ovarian Cancer Cell ◽

Cancer Cell Growth ◽

Inflammatory Drug ◽

Sulindac Sulfide ◽

Anti Inflammatory

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Non-Steroidal Anti-Inflammatory Drug (NSAID) Use and Alzheimer Disease in Community-Dwelling Elderly Patients

American Journal of Geriatric Psychiatry ◽

10.1097/00019442-200303000-00008 ◽

2003 ◽

Vol 11 (2) ◽

pp. 179-185 ◽

Cited By ~ 23

Author(s):

Francesco Landi ◽

Matteo Cesari ◽

Graziano Onder ◽

Andrea Russo ◽

Sergio Torre ◽

...

Keyword(s):

Alzheimer Disease ◽

Elderly Patients ◽

Community Dwelling ◽

Inflammatory Drug ◽

Anti Inflammatory

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Non-steroidal anti-inflammatory drug activated gene (NAG-1) expression is closely related to death receptor-4 and -5 induction, which may explain sulindac sulfide induced gastric cancer cell apoptosis

Carcinogenesis ◽

10.1093/carcin/bgh199 ◽

2004 ◽

Vol 25 (10) ◽

pp. 1853-1858 ◽

Cited By ~ 33

Author(s):

T. J. Jang

Keyword(s):

Gastric Cancer ◽

Cancer Cell ◽

Cell Apoptosis ◽

Gastric Cancer Cell ◽

Death Receptor ◽

Inflammatory Drug ◽

Cancer Cell Apoptosis ◽

Sulindac Sulfide ◽

Anti Inflammatory ◽

Death Receptor 4

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Nonsteroidal anti-inflammatory drug sulindac sulfide suppresses structural protein Nesprin-2 expression in colorectal cancer cells

Biochimica et Biophysica Acta (BBA) - General Subjects ◽

10.1016/j.bbagen.2013.09.032 ◽

2014 ◽

Vol 1840 (1) ◽

pp. 322-331 ◽

Cited By ~ 2

Author(s):

Jason L. Liggett ◽

Chang Kyoung Choi ◽

Robert L. Donnell ◽

Kenneth D. Kihm ◽

Jong-Sik Kim ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Cells ◽

Structural Protein ◽

Inflammatory Drug ◽

Colorectal Cancer Cells ◽

Sulindac Sulfide ◽

Anti Inflammatory

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In search of an anti-inflammatory drug for Alzheimer disease

Nature Reviews Neurology ◽

10.1038/s41582-019-0307-9 ◽

2020 ◽

Vol 16 (3) ◽

pp. 131-132 ◽

Cited By ~ 4

Author(s):

Erika Gyengesi ◽

Gerald Münch

Keyword(s):

Alzheimer Disease ◽

Inflammatory Drug ◽

Anti Inflammatory

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Nonsteroidal anti-inflammatory drug-induced gastrointestinal injury

The American Journal of Medicine ◽

10.1016/s0002-9343(96)90032-7 ◽

1996 ◽

Vol 101 (1) ◽

pp. S25-S32 ◽

Cited By ~ 23

Author(s):

D BJORKMAN

Keyword(s):

Drug Induced ◽

Inflammatory Drug ◽

Gastrointestinal Injury ◽

Anti Inflammatory

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Does eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy reduce the long-term risk of ulcers? A double-blinded randomized trial

Gastroenterology ◽

10.1016/s0016-5085(01)80706-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A143-A143

Author(s):

F CHAN ◽

K TO ◽

J WU ◽

W LEUNG ◽

Y LEE ◽

...

Keyword(s):

Helicobacter Pylori ◽

Drug Therapy ◽

Randomized Trial ◽

Inflammatory Drug ◽

Anti Inflammatory ◽

Double Blinded

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Abstract #209 Phase 4 Study of Safety and Efficacy of The First Anti-Inflammatory Drug Approved in India in Type 2 Diabetes Mellitus (Hydroxychloroquine) - A Preliminary Evaluation

Endocrine Practice ◽

10.1016/s1530-891x(20)47055-7 ◽

2018 ◽

Vol 24 ◽

pp. 31-32

Author(s):

Anilkumar Pareek ◽

Nitin Chandurkar ◽

Ravi Mehta ◽

Kumar Naidu

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Preliminary Evaluation ◽

Safety And Efficacy ◽

Inflammatory Drug ◽

Anti Inflammatory

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Hydrogel Contact Lense for Extended Delivery of an Anti-Biotic in Combination with Anti-Inflammatory Drug for Ophthalmic Application

Asian Journal of Biomedical and Pharmaceutical Sciences ◽

10.15272/ajbps.v5i46.709 ◽

2015 ◽

Vol 05 (46) ◽

pp. 16-21

Author(s):

Chethana SR

Keyword(s):

Inflammatory Drug ◽

Anti Inflammatory ◽

Contact Lense

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