Novel, Highly Sensitive, and Specific Assay to Monitor Acute Myocardial Infarction (AMI) by the Determination of Cardiac Troponin I (cTnI) and Heart-Type Fatty Acid Binding Protein (H-FABP) by a Colloidal Gold-Based Immunochromatographic Test Strip

2020 ◽  
pp. 1-22
Author(s):  
Yuanrong Xin ◽  
Renlong Yang ◽  
Yang Qu ◽  
Hongfei Liu ◽  
Yingshu Feng ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Troponin ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Test Strip ◽  
Immunochromatographic Test ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Highly Sensitive

scholarly journals Rapid test for the qualitative simultaneous determination of cardiac fatty acid-binding protein and cardiac troponin I in the diagnosis of acute coronary syndrome

2019 ◽  
pp. 22-27
Author(s):  
V. A. Kokorin ◽  
I. G. Gordeev ◽  
M. N. Arefyev ◽  
A. Ya. Goncharova ◽  
A. A. Yakovtsova
Keyword(s):  
Simultaneous Determination ◽  
Cardiac Troponin ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Rapid Test ◽  
Fatty Acid Binding ◽  
Coronary Syndrome ◽  
Acid Binding Protein ◽  
Diagnostic Characteristics

Aim. To study the diagnostic characteristics of the rapid test for qualitative simultaneous determination of cardiac fatty acid-binding protein (FABPs) and cardiac troponin I (cTnI) CARD-INFO 1+1 in patients with acute coronary syndrome (ACS).Material and methods. The study included 168 patients undergoing inpatient treatment after ACS, with typical anginal pain lasting at least 20 minutes occurred in the previous 1-24 hours. In addition to routine diagnostic procedures, on admission, we determined FABPs and cTnI concentrations using the high-quality immunochromatographic rapid test CARD-INFO 1 1 (OOO CARDIO-Plus, Russia).Results. The sensitivity of the CARD-INFO 1+1 rapid test was 88,1%, specificity — 89,8%, diagnostic accuracy — 88,7%. The indicators of the diagnostic effectiveness of CARD-INFO 1+1 test in patients with STE-ACS and NSTE-ACS did not significantly differ (p>0,05). The sensitivity of the rapid test reached a maximum in the period from 3 to 6 hours from the onset of pain. Compared with the determination of cTnI performed on admission to the hospital, a higher sensitivity of the CARD-INFO 1+1 test was revealed in patients with STE-ACS (87,7% vs 75,3%; p=0,044), in the first 1-3 hours after the beginning of clinical manifestations (86,8% vs 60,5%; p=0,041) and in the entire sample as a whole (88,1% vs 77,1%; p=0,033), with comparable specificity (89,8% and 93,2%, respectively; p=0,741).Conclusion. Qualitative immunochromatographic CARD-INFO 1+1 rapid test for the simultaneous determination of the content of FABPs and cTnI I is highly effective in the diagnosis of various forms of ACS. The highest diagnostic characteristics of the test were observed in patients in the early stages of the disease (the first 1-6 hours after the onset of pain). Carrying out the CARD-INFO 1+1 test revealed 12 MI cases more (11%) than the first determination of cTnI. Further studies will clarify the place of this technique in the modern algorithm for the management of patients with ACS and evaluate the possibility of using the rapid test in predicting the course of the disease.

Role of heart fatty acid binding protein in early detection of non ST-elevation myocardial infarct and its comparison with other cardiac markers

2020 ◽  
pp. 1-12
Author(s):  
Syed Muhammad Salman Habib ◽  
Abdul Rasheed Khan ◽  
Sultana Habib ◽  
Syed Zia Ullah ◽  
Riffat Sultana ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Binding Protein ◽  
St Elevation Myocardial Infarction ◽  
Cardiac Markers ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
St Elevation

Abstract Objectives: To determine the role of heart fatty acid-binding protein in early detection of non-ST-elevation myocardial infarction and its comparison with two other cardiac markers. Methods: The cross-sectional study was conducted at Abbasi Shaheed Hospital, Karachi, from June 2012 to June 2014, and comprised patients presenting at the emergency department within two hours of chest pain and who were subsequently referred to the cardiology department with a provisional diagnosis of either unstable angina or non-ST-elevation myocardial infarction.  Relevant history was taken on a specific proforma and electrocardiogram as well as routine investigations were done in the emergency department. Blood samples from the subjects were tested for the diagnosis of myocardial infarction through detection of heart fatty acid-binding protein, Troponin-I and Creatine kinase-myocardial band. Sensitivity and specificity of the three markers were calculated keeping coronary angiography as the gold standard. Data was analysed using SPSS 17. Results: Out of 250 patients, 153(61.2%) were males. The overall mean age was 54.45±13.92 years. Sensitivity and specificity of heart fatty acid-binding protein were 80.6% and 78.5% (p<0.05), for Troponin-I, 37.7% and 75% (p>0.05), and for Creatine Kinase-myocardial band, 29.5% and 67.8% (p>0.05). Conclusion: Heart fatty acid-binding protein was found to be a good diagnostic tool for the detection of non-ST-elevation myocardial infarction. Key Words: Non ST-elevation myocardial infarct, Cardiac markers, Heart fatty acid-binding protein, Troponin-I, Creatine kinase isoenzyme MB, Angiography. Continuous...

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