A triple immunochromatographic test for simultaneous determination of cardiac troponin I, fatty acid binding protein, and C-reactive protein biomarkers

2016 ◽  
Vol 184 (2) ◽  
pp. 463-471 ◽  
Author(s):  
Nadezhda A. Byzova ◽  
Anatoly V. Zherdev ◽  
Yury Yu. Vengerov ◽  
Тatyana A. Starovoitova ◽  
Boris B. Dzantiev
Keyword(s):  
Cardiac Troponin ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Immunochromatographic Test ◽  
C Reactive Protein ◽  
Protein Biomarkers ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Acid Binding Protein

scholarly journals Rapid test for the qualitative simultaneous determination of cardiac fatty acid-binding protein and cardiac troponin I in the diagnosis of acute coronary syndrome

2019 ◽  
pp. 22-27
Author(s):  
V. A. Kokorin ◽  
I. G. Gordeev ◽  
M. N. Arefyev ◽  
A. Ya. Goncharova ◽  
A. A. Yakovtsova
Keyword(s):  
Simultaneous Determination ◽  
Cardiac Troponin ◽  
Fatty Acid Binding Protein ◽  
Troponin I ◽  
Rapid Test ◽  
Fatty Acid Binding ◽  
Coronary Syndrome ◽  
Acid Binding Protein ◽  
Diagnostic Characteristics

Aim. To study the diagnostic characteristics of the rapid test for qualitative simultaneous determination of cardiac fatty acid-binding protein (FABPs) and cardiac troponin I (cTnI) CARD-INFO 1+1 in patients with acute coronary syndrome (ACS).Material and methods. The study included 168 patients undergoing inpatient treatment after ACS, with typical anginal pain lasting at least 20 minutes occurred in the previous 1-24 hours. In addition to routine diagnostic procedures, on admission, we determined FABPs and cTnI concentrations using the high-quality immunochromatographic rapid test CARD-INFO 1 1 (OOO CARDIO-Plus, Russia).Results. The sensitivity of the CARD-INFO 1+1 rapid test was 88,1%, specificity — 89,8%, diagnostic accuracy — 88,7%. The indicators of the diagnostic effectiveness of CARD-INFO 1+1 test in patients with STE-ACS and NSTE-ACS did not significantly differ (p>0,05). The sensitivity of the rapid test reached a maximum in the period from 3 to 6 hours from the onset of pain. Compared with the determination of cTnI performed on admission to the hospital, a higher sensitivity of the CARD-INFO 1+1 test was revealed in patients with STE-ACS (87,7% vs 75,3%; p=0,044), in the first 1-3 hours after the beginning of clinical manifestations (86,8% vs 60,5%; p=0,041) and in the entire sample as a whole (88,1% vs 77,1%; p=0,033), with comparable specificity (89,8% and 93,2%, respectively; p=0,741).Conclusion. Qualitative immunochromatographic CARD-INFO 1+1 rapid test for the simultaneous determination of the content of FABPs and cTnI I is highly effective in the diagnosis of various forms of ACS. The highest diagnostic characteristics of the test were observed in patients in the early stages of the disease (the first 1-6 hours after the onset of pain). Carrying out the CARD-INFO 1+1 test revealed 12 MI cases more (11%) than the first determination of cTnI. Further studies will clarify the place of this technique in the modern algorithm for the management of patients with ACS and evaluate the possibility of using the rapid test in predicting the course of the disease.

scholarly journals Methodological utility of chemerin as a novel biomarker of immunity and metabolism

2017 ◽  
Vol 6 (5) ◽  
pp. 340-347 ◽  
Author(s):  
Fabian Eichelmann ◽  
Cornelia Weikert ◽  
Romina di Giuseppe ◽  
Ronald Biemann ◽  
Berend Isermann ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chronic Disease ◽  
Fatty Acid Binding Protein ◽  
Disease Risk ◽  
C Reactive Protein ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Chronic Disease Risk ◽  
Acid Binding Protein

Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses. Intra-individual reproducibility of chemerin measurements was assessed by calculating intraclass correlation coefficients (ICCs) and exploration of Bland–Altman plots. Reliability analyses revealed good reproducibility of chemerin measurements (ICC: 0.72 (95%-CI 0.65, 0.78)). Visual inspection of Bland–Altman plots confirmed that the two time point measurements had a high level of agreement. In correlation analyses, chemerin was positively correlated with adiposity measures (body mass index and waist circumference). In addition, independent of adiposity measures, chemerin was correlated with the biomarkers C-reactive protein, fatty acid-binding protein 4 and progranulin (Rho-s ranging from 0.23 to 0.37). In multivariable linear regression analysis, a combination of correlated factors including body mass index, waist circumference, C-reactive protein, progranulin and fatty acid-binding protein-4 explained 28.0% of chemerin concentrations. These findings demonstrate methodological utility of chemerin concentrations in population-based research setting. Human studies are highly warranted in order to provide further insights into the role of chemerin as a biomarker linking immunity and metabolism in relation to chronic disease risk.

Comparison between C-reactive protein and adipocyte fatty acid-binding protein as a component of metabolic syndrome in middle-aged women

2011 ◽  
Vol 44 (4) ◽  
pp. 304-306 ◽  
Author(s):  
Anna Stefanska ◽  
Grazyna Sypniewska ◽  
Beata Blaszkiewicz ◽  
Irena Ponikowska ◽  
Malgorzata Cwiklinska-Jurkowska
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Fatty Acid Binding ◽  
Reactive Protein ◽  
Acid Binding Protein
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