Synthetic pyrethroids common metabolite 3-phenoxybenzoic acid induces caspase-3 and Bcl-2 mediated apoptosis in human hepatocyte cells

2021 ◽  
pp. 1-7
Author(s):  
Dilek Guvenc ◽  
Sinem Inal ◽  
Nilufer Kuruca ◽  
Sedat Gokmen ◽  
Tolga Guvenc
Keyword(s):  
Caspase 3 ◽  
Human Hepatocyte ◽  
Synthetic Pyrethroids ◽  
Hepatocyte Cells

scholarly journals AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells

FEBS Journal ◽  
2010 ◽  
Vol 277 (10) ◽  
pp. 2304-2317 ◽  
Author(s):  
In-uk Koh ◽  
Joo H. Lim ◽  
Myung K. Joe ◽  
Won H. Kim ◽  
Myeong H. Jung ◽  
...  
Keyword(s):  
Er Stress ◽  
Human Hepatocyte ◽  
Hepatocyte Cells

scholarly journals In Vitro Cytotoxicity Test Reveals Non-toxic of Waste-based Scaffold on Human Hepatocyte Cells

2021 ◽  
Vol 10 (1) ◽  
pp. 109
Author(s):  
Oktantia Frenny Anggani ◽  
Aniek Setiya Budiatin ◽  
Laksmi Sulmartiwi ◽  
Muhammad Rahmad Royan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Viability ◽  
Chondroitin Sulfate ◽  
In Vitro Cytotoxicity ◽  
Human Hepatocyte ◽  
Cytotoxicity Test ◽  
C 50 ◽  
Hepatocyte Cells ◽  
Dose Dependent

Scaffold, as one of the components for bone tissue engineering, requires formulated biomaterials that are both structurally and compositively similar to bone composition. Among others, chitosan, gelatin and chondroitin sulfate are known as potential candidates for scaffold composites that can be easily obtained from waste-based resources. This study aims to investigate the cytotoxicity of different scaffold composition and concentration regimes derived from waste-based chitosan, gelatine and chondroitin sulfate, in vitro. The composition regimes used were (Chitosan : Gelatin : Chondroitin Sulfate) 50 : 50 : 0 (A); 50 : 40 :10 (B); 50 : 35 : 15 (C); 50 : 30 : 20 (D); 50 : 25 : 25 (E). Meanwhile, the final concentrations of scaffold used were 2000, 1000, 500, 250, 100, 10 and 0,1 mg/ml. The different compositions and concentrations of scaffold was tested against Hepatocellular Carcinoma (Huh7it / Human Hepatocyte It). After 48-hour incubation in the scaffold solution, the percentage of cell viability was evaluated using 3-(4,5-dimethylthiazol-2yl)-5(3-carboxymethoxyphenyl)-2- (4-sulfophenyl)-2H-tetrazolium (MTT) assay. The result shows that there is no difference observed among different scaffold compositions on the cell viability (p > 0.05). However, different concentrations of scaffold show significant differences in cell viability in composition C and E (p < 0.01), suggesting possible dose- dependent effect of scaffold on cell viability. Overall, all the waste-based scaffold compositions show no toxicity against the Hepatocellular Carcinoma cells as exhibited by the cell viability that is above 70%, at least with the concentration up to 2000 mg/ml.

Effects of PACAP on Oxidative Stress-Induced Cell Death in Rat Kidney and Human Hepatocyte Cells

2010 ◽  
Vol 43 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Gabriella Horvath ◽  
Reka Brubel ◽  
Krisztina Kovacs ◽  
Dora Reglodi ◽  
Balazs Opper ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Rat Kidney ◽  
Human Hepatocyte ◽  
Hepatocyte Cells

scholarly journals Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon-induced antiviral protein in human hepatocyte cells

2008 ◽  
Vol 14 (3) ◽  
pp. 292-298 ◽  
Author(s):  
Kumi Hirano ◽  
Tatsuki Ichikawa ◽  
Kazuhiko Nakao ◽  
Azusa Matsumoto ◽  
Hisamitsu Miyaaki ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Calcineurin Inhibitors ◽  
Human Hepatocyte ◽  
Antiviral Protein ◽  
Differential Effects ◽  
Hepatocyte Cells

Natural pyrethrins induces apoptosis in human hepatocyte cells via Bax- and Bcl-2-mediated mitochondrial pathway

2017 ◽  
Vol 262 ◽  
pp. 38-45 ◽  
Author(s):  
Yun Yang ◽  
Mimi Zong ◽  
Wenping Xu ◽  
Yang Zhang ◽  
Bo Wang ◽  
...  
Keyword(s):  
Mitochondrial Pathway ◽  
Human Hepatocyte ◽  
Hepatocyte Cells
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