scholarly journals Design and evaluation of an open-source, conformable skin-cooling system for body magnetic resonance guided focused ultrasound treatments

2021 ◽  
Vol 38 (1) ◽  
pp. 679-690
Author(s):  
Robb Merrill ◽  
Henrik Odéen ◽  
Christopher Dillon ◽  
Rachelle Bitton ◽  
Pejman Ghanouni ◽  
...  
2020 ◽  
Author(s):  
Robb Merrill ◽  
Henrik Odéen ◽  
Christopher Dillon ◽  
Rachelle Bitton ◽  
Pejman Ghanouni ◽  
...  

The adverse event of skin burns and the restrictions caused by multi-hour treatment times continue to limit the clinical efficacy and cost effectiveness of MRgFUS thermal therapies. This proposal directly addresses these unmet needs with two primary aims. Aim 1 includes design and fabrication of a prototype cooling device, testing of clinically identified design specifications, and initial experimental validation ex vivo tissue experiments. This conformable skin-cooling device will reduce the potential for skin burns in desmoid tumor and other MRgFUS treatments. Aim 2 will assess the skin cooling device on a pre-clinical MRgFUS system with rabbit and pig studies and will integrate the device with the clinical ExAblate 2100 system. The ultimate goal of the device design is to be MRgFUS system independent. This may require a modular design that allows for both clinical and veterinarian applications. The completion of this proposal will deliver the engineering schematic, parts list and use manual of the completed device, validation data and install a single device at the Focused Ultrasound Center of Excellence at Stanford University.Presented here are the open-source parts list and assembly files to reproduce the skin cooling device, along with the device user manual. An open-access publication on the design methods and preclinical results will be published soon.


2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Megan E. Poorman ◽  
Vandiver L. Chaplin ◽  
Ken Wilkens ◽  
Mary D. Dockery ◽  
Todd D. Giorgio ◽  
...  

Author(s):  
Megan E. Poorman ◽  
Vandiver L. Chaplin ◽  
Ken Wilkens ◽  
Mary D. Dockery ◽  
Todd D. Giorgio ◽  
...  

2020 ◽  
pp. 1-9 ◽  
Author(s):  
Benjamin Davidson ◽  
Karim Mithani ◽  
Yuexi Huang ◽  
Ryan M. Jones ◽  
Maged Goubran ◽  
...  

OBJECTIVEMagnetic resonance imaging–guided focused ultrasound (MRgFUS) is an emerging treatment modality that enables incisionless ablative neurosurgical procedures. Bilateral MRgFUS capsulotomy has recently been demonstrated to be safe and effective in treating obsessive-compulsive disorder (OCD) and major depressive disorder (MDD). Preliminary evidence has suggested that bilateral MRgFUS capsulotomy can present increased difficulties in reaching lesional temperatures as compared to unilateral thalamotomy. The authors of this article aimed to study the parameters associated with successful MRgFUS capsulotomy lesioning and to present longitudinal radiographic findings following MRgFUS capsulotomy.METHODSUsing data from 22 attempted MRgFUS capsulotomy treatments, the authors investigated the relationship between various sonication parameters and the maximal temperature achieved at the intracranial target. Lesion volume and morphology were analyzed longitudinally using structural and diffusion tensor imaging. A retreatment procedure was attempted in one patient, and their postoperative imaging is presented.RESULTSSkull density ratio (SDR), skull thickness, and angle of incidence were significantly correlated with the maximal temperature achieved. MRgFUS capsulotomy lesions appeared similar to those following MRgFUS thalamotomy, with three concentric zones observed on MRI. Lesion volumes regressed substantially over time following MRgFUS. Fractional anisotropy analysis revealed a disruption in white matter integrity, followed by a gradual return to near-baseline levels concurrent with lesion regression. In the patient who underwent retreatment, successful bilateral lesioning was achieved, and there were no adverse clinical or radiographic events.CONCLUSIONSWith the current iteration of MRgFUS technology, skull-related parameters such as SDR, skull thickness, and angle of incidence should be considered when selecting patients suitable for MRgFUS capsulotomy. Lesions appear to follow morphological patterns similar to what is seen following MRgFUS thalamotomy. Retreatment appears to be safe, although additional cases will be necessary to further evaluate the associated safety profile.


2021 ◽  
Vol 91 ◽  
pp. 75-79
Author(s):  
David N. Wilson ◽  
Yael Barnett ◽  
Kain Kyle ◽  
Stephen Tisch ◽  
Benjamin P. Jonker

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