The Sustained Release of Tafluprost with a Drug Delivery System Prevents the Axonal Injury-induced Loss of Retinal Ganglion Cells in Rats

Microspheres carrier system made from natural or synthetic polymers used in sustained release drug delivery system. The present study involves formulation and evaluation of floating microspheres of Curcumin for improving the drug bioavailability by prolongation gastric residence time. Curcumin, natural hypoglycemic agent is a lipophilic drug, absorbed poorly from the stomach, quickly eliminated and having short half-life so suitable to formulate floating drug delivery system for sustained release. Floating microspheres of curcumin were formulated by solvent evaporation technique using ethanol and dichloromethane (1:1) as organic solvent and incorporating various synthetic polymers as coating polymer, sustain release polymers and floating agent. The final formulation were evaluated various parameters such as compatibility studies, micrometric properties, In-vitro drug release and % buoyancy. FTIR studies showed that there were no interaction between drug and excipients. The surface morphology studies by SEM confirmed their spherical and smooth surface. The mean particles size were found to be 416-618µm, practical yield of microspheres was in the range of 60.21±0.052% - 80.87±0.043%, drug entrapment efficiency 47.4±0.065% - 77.9±0.036% and % buoyancy 62,24±0.161% - 88.63±0.413%. Result show that entraptmency increased as polymer (Eudragit RS100) conc. Increased. The drug release after 12 hrs. was 72.13% - 87.13% and it decrease as a polymer (HPMC, EC) concentration was decrease.

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Implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system

Drug Delivery Letters ◽

10.2174/2210303111666210421121812 ◽

2021 ◽

Vol 11 ◽

Author(s):

Lalit Singh ◽

Vijay Sharma

Keyword(s):

Mathematical Model ◽

Drug Delivery ◽

Sustained Release ◽

Drug Delivery System ◽

Delivery System ◽

Dosage Form ◽

Quality By Design ◽

Design Principles ◽

Release Drug

Aim: Aim of the present work is implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system Background: Quality by Design (QbD) approach refers to an advance approach to develop a optimized dosage form.QbD has become a vital modern scientific approach to develop a quality dosage form.In modern era of science researcher can develop a optimized dosage form with least effort, money and manpower. Objectives: Objective of research work wasthe successful development of optimized floating bioadhesive tablets of glipizide using floating-bioadhesive potential of cellulosic polymer and carbomersusing quality by design (QbD) approach. Method: Quality Target Product Profile (QTPP) of drug delivery system was defined as well as critical quality attributes (CQAs) were identified. A face centered central composite design (CCD) was utilized in assessing the impact of individual critical material attribute (CMA) like Hydro Propyl Methyl Cellulose K4M(HPMC K4M)and Carbopol 934P (CP 934P) and their interactions, using least experimentation. Formulations were developed and quantitative impact on CQAs was determined using mathematical model. The optimized formulation was obtained and characterized for in-vitro as well as in-vivo parameters. Results: A Fishikawa diagram and Failure Mode and Effect Analysis (FMEA) were performed to identify potential failure modes associated with the dosage form. The optimum formulation was embarked upon using mathematical model developed yielding desired CQAs followed for confirmation of data. Sustained release drug delivery system was successfully developed by using QbD approach. In-vivo X-ray imaging in rabbit and γ-scintigraphic study in manconfirmed the buoyant nature of the mucoadhesive floating tablet for 8 h in the upper gastrointestinal tract. Conclusion: Optimized formulation shows phenomenal floating, bioadhesive properties and drug release retardation characteristics, utilizing a mixture of cost-effective polymers Hence, QbD approach may be regarded as an important tool in development of floating bioadhesive CR dosage forms.

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Clarithromycin based oral sustained release nanoparticulate drug delivery system

Indian Journal of Pharmaceutical Sciences ◽

10.4103/0250-474x.27822 ◽

2006 ◽

Vol 68 (4) ◽

pp. 479 ◽

Cited By ~ 19

Author(s):

NK Jain ◽

Suman Ramteke ◽

RB Uma Maheshwari

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery System ◽

Delivery System

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SOMES: A REVIEW ON COMPOSITION, FORMULATION METHODS AND EVALUATIONS OF DIFFERENT TYPES OF “SOMES” DRUG DELIVERY SYSTEM

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2020v12i6.38996 ◽

2020 ◽

pp. 7-18

Author(s):

KUSUMA PRIYA M. D. ◽

VINOD KUMAR ◽

DAMINI V. K. ◽

ESWAR K. ◽

KADIRI RAJESH REDDY ◽

...

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Surface Chemistry ◽

Drug Delivery System ◽

Delivery System ◽

Different Types ◽

Potent Drug ◽

Evaluation Parameters ◽

Selection Of

Many drugs are available in the market for several diseases, disorder or even for a condition, but it is difficult to select a suitable carrier to attain maximum bioavailability and potential for a potent drug. Attaining a controlled and sustained release of a drug is purely focused on the selection of a carrier (natural, synthetic and hybrid) like nanosomes. Nanosomes have become a prominent tool in the field of pharmacy. Nanosomes are small uniform structures which deliver the drug to the specific targeted site, which mainly depends upon the presence of ligands, shape, size and surface chemistry. Nanosomes are available in various types which include Niosomes, Liposomes, Electrosomes, Aquasomes, Transfersomes, Phytosomes, Enzymosomes, Ethosomes, Invasome and Sphingosomes. In general, all these nanosomes are quite similar in nature with minute differences in their vesicular characteristics and composition. This review traces various ‘somes’ composition and their role in the formulation, applications, advantages, disadvantages, common formulation procedures and evaluation parameters.

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