scholarly journals Evaluation of the possible association of body mass index and four metabolic gene polymorphisms with longevity in an Italian cohort: a role for APOE, eNOS and FTO gene polymorphisms

2019 ◽  
Vol 46 (5) ◽  
pp. 425-429 ◽  
Author(s):  
Alfredo Santovito ◽  
Gabriella Galli ◽  
Stefano Ruberto
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gene Polymorphisms ◽  
Fto Gene ◽  
Metabolic Gene ◽  
Italian Cohort

Evaluation of the possible association of Body Mass Index and four metabolic gene polymorphisms with longevity in an Italian cohort: a role forAPOE, eNOS, andFTOgene polymorphisms

2019 ◽  
Author(s):  
Alfredo Santovito ◽  
Gabriella Galli ◽  
Stefano Ruberto
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gene Polymorphisms ◽  
Genetic Factors ◽  
Age Groups ◽  
Population Data ◽  
Allele Frequencies ◽  
Age Group ◽  
Italian Cohort

ABSTRACTBackgroundlongevity is considered the result of interactions between environmental and genetic factors.Aimwe investigated the possible association of body mass index and the frequencies ofAPOE, ACE, eNOS, andFTOgene polymorphisms with longevity.Subjects and Method1,100 healthy volunteers aged 10-100 were recruited. We genotyped subjects forAPOE, ACE, eNOS, andFTOgene polymorphisms. Data about height and weight were also collected. The sample was split in four age groups: 1-24, 25-49, 50-85 and 86-100.Resultssignificant differences were found in BMI values between age groups, with exception of 1-24 with respect to 86-100. A significant decrease of theAPO E4, eNOS 393andFTO Aand allele frequencies was observed in the 86-100 age group with respect to younger groups. ForACEgene, no significant differences were found in the allele frequencies between groups. A similar trend was also observed subdividing the sample in two main age groups: 1-85 and 86-100.Conclusionthis study provides evidences for a role ofAPOE, eNOS, andFTOgene polymorphisms in longevity. It has been estimated that the number of centenarians worldwide will double each decade until 2100, making population data about gene polymorphisms relevant for further studies about longevity.

scholarly journals W86. FTO GENE POLYMORPHISMS AND BODY MASS INDEX IN SCHIZOPHRENIA PATIENTS WITH METABOLIC SYNDROME

2021 ◽  
Vol 51 ◽  
pp. e190
Author(s):  
Anastasiia Boiko ◽  
Ivan Pozhidaev ◽  
Diana Paderina ◽  
Elena Kornetova ◽  
Anton J.M. Loonen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Body Mass ◽  
Gene Polymorphisms ◽  
Fto Gene

The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

2018 ◽  
Vol 120 (4) ◽  
pp. 6441-6448 ◽  
Author(s):  
Negin Rezavand ◽  
Saba Tabarok ◽  
Ziba Rahimi ◽  
Asad Vaisi‐Raygani ◽  
Ehsan Mohammadi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Vitamin D ◽  
Body Mass ◽  
Gestational Age ◽  
Gene Polymorphisms ◽  
Vdr Gene ◽  
Vdr Gene Polymorphisms ◽  
Risk Of Preeclampsia

scholarly journals The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents

2011 ◽  
Vol 36 (1) ◽  
pp. 61-68 ◽  
Author(s):  
D M Hallman ◽  
V C Friedel ◽  
M A H Eissa ◽  
E Boerwinkle ◽  
J C Huber ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Children And Adolescents ◽  
Body Mass ◽  
Fto Gene ◽  
White Children ◽  
Hispanic White

scholarly journals Effect ofGAS6andAXLGene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Fone-Ching Hsiao ◽  
Yuh-Feng Lin ◽  
Po-Shiuan Hsieh ◽  
Nain-Feng Chu ◽  
Yii-Der Ida Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Waist Circumference ◽  
Body Mass ◽  
Systemic Inflammation ◽  
Gene Polymorphisms ◽  
Insulin Levels ◽  
Heart Study ◽  
Significant Difference ◽  
Multistage Sampling

The present study was designed to explore the effects ofGAS6andAXLgene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents’GAS6rs8191973,GAS6rs8191974,AXLrs4802113, andAXLrs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype ofGAS6rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype ofAXLrs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with the TT, TC, and CC genotypes ofAXLrs4802113. Boys with both the GG genotype ofGAS6rs8191973 and the GG genotype ofGAS6rs8191974 exhibited higher BMI, WC, IL-6, and hsCRP levels than the boys carrying both the C allele of theGAS6rs8191973 and the A allele of theGAS6rs8191974. In conclusion,GAS6andAXLpolymorphisms are associated with adiposity, systemic inflammation, and insulin resistance in adolescents, especially in boys.

scholarly journals Decrease in body mass index: Personal genotyping, individual diet, and exercise plan

2017 ◽  
Vol 7 (2) ◽  
pp. 91-98
Author(s):  
Mirela Dzehverovic ◽  
Anesa Ahatovic ◽  
Naris Pojskic ◽  
Naida Lojo-Kadric ◽  
Amela Pilav ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gene Polymorphisms ◽  
Dna Analysis ◽  
Personal Data ◽  
Nucleotide Polymorphisms ◽  
Tissue Accumulation ◽  
Training Plan ◽  
Significant Difference ◽  
Before And After

Introduction: Single nucleotide polymorphisms (SNPs) have lately been used for prediction of metabolic processes that may be related to obesity. The aim of our study was to examine the association of SNPs of several genes with obesity and physical activity in 18 healthy volunteers. Methods: We used buccal swabs to collect and extract DNA from 18 volunteers. Pyrosequencing was used for molecular analysis of 13 polymorphisms in 10 genes (APOA2, MTHFR, MCM6, peroxisome proliferators-activated receptor gamma, FABP2, beta-2-adrenergic receptor (ADRB)2, ADRB3, A-actinin-3, angiotensin-converting enzyme, and FUT2). The volunteers’ personal data included body mass index (BMI), dietary practice and information on daily fitness and workout routine. Association between the 13 observed gene polymorphisms and individual BMI status (normal or overweight) was analyzed. Results of the DNA analysis were used for the expert evaluation by nutritionists and physiologists to obtain optimal regulation of nutrition and exercise. The volunteers had a dietary and fitness program for 12 months which they tracked by filling in a suitable study form. Results: 14 volunteers had a moderate genetic predisposition for abdominal adipose-tissue accumulation, while 4 of them had genotypes not associated with abdominal fat tissue accumulation. A statistically significant difference was found between the value of BMI before and after the implementation of personalized training and nutrition plan within the group of overweight volunteers (paired sample t=3.382; p = 0.006; exact p = 0.015). The single-locus F-test showed no association between the gene polymorphisms and BMI values. In addition, no correlation was detected between the gene polymorphisms and amount of BMI reduction prior and after the implementation of the personalized training and nutrition plan within the overweighed group of volunteers. Conclusion: Optimal nutrition and training plan are crucial for the BMI reduction as observed in the overweighed volunteers after the 12-month personalized training and individualized nutrition plan. However, the analyzed polymorphisms were not significantly associated with the obesity in this study.

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