The effect of VDR gene polymorphisms and vitamin D level on blood pressure, risk of preeclampsia, gestational age, and body mass index

Abstract Background Vitamin D deficiency is associated with cardiovascular diseases, including coronary artery diseases (CAD). As vitamin D manifests its biological function through its vitamin D receptor (VDR), VDR gene polymorphisms potentially affect VDR functionality and vitamin D activity. Therefore, the objective of this study was to analyze three well-studied VDR gene polymorphisms—Fok1 (rs2228570), BsmI (rs1544410) and Taq1 (rs731236)—in a cohort of CAD patients after acute myocardial infarction. Methods In the presented cross-sectional study, 155 participants with CAD after acute myocardial infarction and 104 participants in a control group without CAD were enrolled. The participants in both groups were Caucasians of European origin. The genotyping of VDR polymorphisms rs2228570, rs1544410 and rs731236 was assessed by RT-PCR. Results The results show an association between the T/T genotype of the BsmI (rs1544410) and the G/G genotype of the Taq1 (rs731236) VDR polymorphism and CAD patients after acute myocardial infarction. There was no association between the Fok1 (rs2228570) VDR polymorphism and CAD patients after acute myocardial infarction. Conclusion The presented results suggest a potential association of the BsmI (rs1544410) and Taq1 (rs731236) VDR polymorphisms with CAD patients after myocardial infarction.

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The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

BioMed Research International ◽

10.1155/2013/295791 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 8

Author(s):

Bahar Toptaş ◽

Ali Metin Kafadar ◽

Canan Cacina ◽

Saime Turan ◽

Leman Melis Yurdum ◽

...

Keyword(s):

Vitamin D ◽

Cancer Patients ◽

Vitamin D Receptor ◽

Brain Cancer ◽

Gene Polymorphisms ◽

Vdr Gene ◽

Increased Risk ◽

Vdr Gene Polymorphisms ◽

Significant Difference ◽

Healthy Control

Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma.Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP).Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles.Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.

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Vitamin D receptor (VDR) gene polymorphisms and Graves’ disease: a meta-analysis

Clinical Endocrinology ◽

10.1111/j.1365-2265.2008.03413.x ◽

2009 ◽

Vol 70 (6) ◽

pp. 938-945 ◽

Cited By ~ 43

Author(s):

Haiyang Zhou ◽

Chenggang Xu ◽

Mingjun Gu

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Graves Disease ◽

Vdr Gene ◽

Vdr Gene Polymorphisms

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Vitamin D status in apparently healthy medication-free Slovaks: Association to blood pressure, body mass index, self-reported smoking status and physical activity

Bratislava Medical Journal ◽

10.4149/bll_2016_135 ◽

2017 ◽

Vol 117 (12) ◽

pp. 702-709 ◽

Cited By ~ 2

Author(s):

K. Sebekova ◽

Z. Krivosikova ◽

M. Gajdos ◽

L Podracka

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

Body Mass Index ◽

Vitamin D ◽

Body Mass ◽

Smoking Status ◽

Vitamin D Status ◽

Apparently Healthy

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Vitamin D receptor genetic polymorphisms were associated with oral lichen planus susceptibility in Chinese Han population

10.21203/rs.2.10415/v1 ◽

2019 ◽

Author(s):

Hong Shen ◽

Qinglan Liu ◽

Peng Huang ◽

Haozhi Fan ◽

Feng Zang ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Gene Polymorphisms ◽

Oral Lichen Planus ◽

Recessive Model ◽

Chinese Han ◽

Vdr Gene ◽

Han Population ◽

Vdr Gene Polymorphisms ◽

Oral Lichen

Abstract Vitamin D receptor (VDR) is involved in multiple immune-mediated disorders including Oral lichen planus (OLP). This study was aimed to investigate the association between VDR gene polymorphisms and the risk of OLP. 177 OLP patients and 207 healthy participants were recruited from Affiliated Hospital of Stomatology, Nanjing Medical University. Eight single nucleotide polymorphisms (SNPs: rs731236, rs739837, rs757343, rs2107301, rs2239185, rs7975232, rs11574129 and rs11568820) on the VDR gene were selected and genotyped. The results showed that the OLP risk was increased in subjects with the rs2239185 TT genotype (Recessive model: adjusted OR = 2.68, 95% CI = 1.28-5.62, P = 0.009) and rs7975232 CC genotype (Recessive model: adjusted OR = 2.25, 95% CI = 1.10-4.58, P = 0.026). And the significant cumulative effects on OLP risk were found in rs2239185 and rs7975232 (P < 0.01). The haplotype analysis showed that haplotype CC (rs2239185-rs7975232) was associated with increased OLP risk (OR =3.11, 95% CI = 1.42-6.83, P = 0.005), compared with haplotype AC. In conclusion, the variants of VDR rs2239185 and rs7975232 may influence the OLP susceptibility and VDR gene polymorphisms may be the candidate susceptibility region of OLP in Chinese Han population.

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Association of vitamin D receptor gene polymorphisms with rheumatoid arthritis

Archives of Medical Science ◽

10.5114/aoms/116606 ◽

2021 ◽

Author(s):

Noelia Marquez Pete ◽

Cristina Perez Ramirez ◽

Maria del Mar Maldonado Montoro ◽

Fernando Martinez Martinez ◽

Fernando Fernández-Llimos ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Vitamin D ◽

Gene Polymorphisms ◽

Haplotype Analysis ◽

Functional Disability ◽

Receptor Gene ◽

Unknown Etiology ◽

Vdr Gene ◽

Vdr Gene Polymorphisms ◽

Receptor Gene Polymorphisms

IntroductionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease of unknown etiology which causes progressive deterioration of the joints, leading to severe pain and functional disability. Vitamin D and its receptor (VDR) play a significant part in the onset of autoimmune diseases such as RA. The purpose of this study was to evaluate the association between VDR gene polymorphisms and risk of developing RA.Material and methodsA retrospective study was performed, including 214 RA cases and 748 controls of Caucasian origin. FokI (rs2228570), BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and Cdx2 (rs11568820) gene polymorphisms were analyzed by TaqManResultsThe recessive logistic regression model showed that the VDR FokIAA genotype was associated with lower risk of RA (p = 0.0255; OR = 0.58; 95% CI: 0.35–0.92). No other genetic polymorphism showed any association with RA in any of the models tested. Haplotype analysis revealed that the haplotypes ACGAG (p = 0.033; OR = 1.62; 95% CI: 1.04–2.53) and GTGCA (p < 0.01; OR = 2.77; 95% CI: 1.53–4.98) for BsmI, Cdx2, FokI, ApaI and TaqI were associated with higher risk of RA.ConclusionsVDR FokI gene polymorphism showed a trend for risk of RA, taking into account the variables of gender, age and tobacco use, and preventing false positives. Among our patients we found no influence of VDR BsmI, TaqI, ApaI and Cdx2 on the risk of developing RA. However, haplotype analysis indicated that the haplotypes ACGAG and GTGCA were associated with higher risk of RA.

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