Haptoglobin polymorphism in Egyptians

This review outlines the current clinical research investigating how the haptoglobin (Hp) genetic polymorphism and stroke occurrence are implicated in sickle cell disease (SCD) pathophysiology. Hp is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. The role of Hp in patients with SCD is critical in combating blood toxicity, inflammation, oxidative stress, and even stroke. Ischemic stroke occurs when a blocked vessel decreases oxygen delivery in the blood to cerebral tissue and is commonly associated with SCD. Due to the malformed red blood cells of sickle hemoglobin S, blockage of blood flow is much more prevalent in patients with SCD. This review is the first to evaluate the role of the Hp polymorphism in the incidence of stroke in patients with SCD. Overall, the data compiled in this review suggest that further studies should be conducted to reveal and evaluate potential clinical advancements for gene therapy and Hp infusions.

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Haptoglobin polymorphism, plasma haptoglobin level and ABO blood group in leprosy patients

Journal of Coastal Life Medicine ◽

10.12980/jclm.5.2017j7-151 ◽

2017 ◽

Vol 5 (12) ◽

pp. 550-555 ◽

Cited By ~ 7

Author(s):

Nigussie Seboka ◽

◽

Endashaw Bekele ◽

Shimelis Nigussie ◽

Yonas Bekele ◽

...

Keyword(s):

Blood Group ◽

Abo Blood Group ◽

Leprosy Patients ◽

Haptoglobin Level ◽

Plasma Haptoglobin ◽

Haptoglobin Polymorphism

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1042-77 Haptoglobin polymorphism is associated with short-term mortality and heart failure in patients with diabetes and acute myocardial infarction

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(04)91093-5 ◽

2004 ◽

Vol 43 (5) ◽

pp. A257

Author(s):

Mahmoud Suleiman ◽

Doron Aronson ◽

Michael Kapeliovich ◽

Walter Markiewicz ◽

Haim Hammerman ◽

...

Keyword(s):

Myocardial Infarction ◽

Heart Failure ◽

Acute Myocardial Infarction ◽

Short Term ◽

Patients With Diabetes ◽

Short Term Mortality ◽

Haptoglobin Polymorphism

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Haptoglobin Polymorphism Association with Magnesium and Lipid Profile in Healthy Teenagers

Trace Elements in Man and Animals 10 ◽

10.1007/0-306-47466-2_100 ◽

2002 ◽

pp. 333-334

Author(s):

M. Bicho ◽

C. P. Monteiro ◽

L. Sardinha ◽

S. Llobet ◽

P. Marques Vidal ◽

...

Keyword(s):

Lipid Profile ◽

Haptoglobin Polymorphism

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HAPTOGLOBIN POLYMORPHISM AND CHRONIC TENDINOPATHY

Journal of Musculoskeletal Research ◽

10.1142/s0218957720500086 ◽

2020 ◽

Vol 23 (02) ◽

pp. 2050008

Author(s):

Jihad A. M. Alzyoud ◽

Seham T. Abdelall ◽

Abd Al-Rahman S. Al-Shudiefat ◽

Dawood Moh’d Khalyaila ◽

Saleh A. Al Najjar

Keyword(s):

Potential Role ◽

Case Control Study ◽

Polyacrylamide Gel Electrophoresis ◽

Sodium Dodecyl ◽

Exact Test ◽

Potential Association ◽

And Gender ◽

Electrophoresis Technique ◽

Control Study ◽

Haptoglobin Polymorphism

Introduction: Tendinopathy is a pathology of tendons of multifactorial origin displayed clinically as chronic degenerative tissue resulting in dysfunction and painful musculoskeletal system. Genetic implications in tendinopathy are not fully elucidated. Haptoglobin (Hp) polymorphism has been investigated for potential role in several diseases such as cardiovascular diseases. This study aims at investigating Hp polymorphism potential association with chronic tendinopathy in Jordan. Materials and Methods: A hospital-based case-control study, of 101 patients diagnosed with chronic tendinopathy and 104 age and gender matched controls, was employed and Hpphenotypes distributions were determined using Sodium Dodecyl Sulphate Polyacrylamide gel electrophoresis technique. Results: showed a significant association between tendinopathy cases and controls in relation to Hpphenotypes frequencies (Fisher’s Exact Test, [Formula: see text]). Odd ratios showed that the odds of tendinopathy cases in Hp2.1 group were reduced while odds in Hp2.2 and Hp1.1 were increased by 3.22 and 7.34 times, respectively, as likely compared to the controls. Conclusion: Results suggested that Hppolymorphism might play a role in chronic tendinopathy genesis.

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