NEW ASPECTS IN THE MECHANISM OF INHIBITORY ACTION OF SULPHUR CONTAINING METAL COMPLEX COMPOUNDS IN THE OXIDATION OF HYDROCARBONS

1979 ◽  
Vol 6 (1-2) ◽  
pp. 141-142
Author(s):  
Slavi K. Ivanov
Physica B+C ◽  
1977 ◽  
Vol 86-88 ◽  
pp. 655-656 ◽  
Author(s):  
I.S. Jacobs ◽  
H.R. Hart ◽  
L.V. Interrante ◽  
J.W. Bray ◽  
J.S. Kasper ◽  
...  

2012 ◽  
Vol 10 (3) ◽  
pp. 28-34
Author(s):  
Denis Vladimirovich Sosin ◽  
Andrey Viktorovich Yevseyev ◽  
Edgar Andreyevich Parfenov ◽  
Vitaliy Andreyevich Pravdivtsev ◽  
Marina Anatolyevna Yevseyeva ◽  
...  

In experiments on mice undergone to an acute hypercapnic hypoxia and an acute hypobaric hypoxia a screening of antihypoxants among new selenium containing metal complex substances was performed after their intra-abdominal and oral introductions. It was found that substances πQ1983 and πQ2170 on both models of hypoxia make the defensive effects surpassing actions well-known antihypoxants such as amthizole and bemythil. It was shown that antihypoxiс affects of studied substances depend on their caused hypothermia. For the first time the protective action of selenium containing metal complex compounds was demonstrated after their introduction per os.


2019 ◽  
Vol 17 (1) ◽  
pp. 81-86
Author(s):  
V.M. Farzaliyev ◽  
◽  
M.P. Bayramov ◽  
S.Kh. Jafarzadeh ◽  
P.Sh. Mammadova ◽  
...  

2015 ◽  
Vol 13 (1) ◽  
pp. 3-24
Author(s):  
Denis Vladimirovich Sosin ◽  
Ol'ga Evgen'yevna Shalaeva ◽  
Andrey Viktorovich Yevseyev ◽  
Petr Dmitriyevich Shabanov

The common mechanisms of acute exogenous hypoxia formation and ways of organism adaptation to this condition are considered in the review. The characteristics of brain bioelectrical activities and its energy metabolism during acute exogenous hypoxia are described in detail. Special attention has been devoted to the problem of acute hypoxia pharmacological correction by antihypoxants with emphasis on possibility to use metal-complex compounds including variable valence metals and nature biologically active substances as hypoxprotectors. The original data confirm high efficacy of zinc-contained metal-complex antihypoxants in acute hypoxia formation. The prospects of selenium-containing metal-complexes with zinc (II) as a center of complex molecule are noted.


2013 ◽  
Vol 11 (2) ◽  
pp. 45-51
Author(s):  
Denis Vladimirovich Sosin ◽  
Vitaliy Andreyevich Pravdivtsev ◽  
Marina Anatolyevna Yevseyeva ◽  
Andrey Viktorovich Yevseyev ◽  
Petr Dmitriyevich Shabanov

Fine changes of electrical activities in rat myocardium were studied after oral introduction of new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and after an acute hypercapnichypoxia (AH + Hc) development. A substance for comparison — metabolic antihypoxant amthizole was used by same way and dose. The substances were introduced 90 min before (incubation period) placing of animals into hypoxic chambers with 1.0 L free volume. ECG was recorded continually during both an incubation period and a hypoxic experiment. It has been established that the inhibitory action of the substance πQ1983 on electrical activity of rat myocardium manifests itself like a significant bradycardia. According with ECG data, rats protected with substance πQ1983 show the resistance level to the AH + Hc higher than ones that intake the antihypoxant amthizole. It was proved by peculiarities of early myocardial hypercapnic reactions, parameters of lifespan, and length of so called relative wellbeing period.


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