Effect of Hemodialysis on the Content of Fatty Acids in Monolayers of Erythrocyte Membranes in Patients with Chronic Renal Failure

Dyslipidemia and increases in plasma homocysteine usually occur at end-stage renal disease; both are recognized as risk factors for atherosclerosis. Folate administration reduces homocysteine concentration. In this study we determined the effect of a high dose of folic acid (40 mg intravenous injection three times a week) on plasma and red blood cell lipid profiles in twelve chronic renal failure patients on regular hemodialysis. Fasting blood samples were taken at the beginning of the study (baseline) and after 21, 42, and 64 days of treatment. Folic acid supplementation decreased plasma homocysteine. Plasma triglyceride levels decreased whereas polyunsaturated fatty acid values increased after 21 days; then they returned to baseline levels at the end of treatment. Total cholesterol and low-density lipoprotein (LDL) cholesterol were higher than those of the baseline during all the study, whereas high-density lipoprotein (HDL) cholesterol was reduced. In erythrocyte membranes, folic acid therapy enhanced cholesterol/phospholipid ratios and the fluorescence anisotropy of diphenyl-hexatriene. We conclude that large doses of folic acid produce a favorable effect, reducing plasma homocysteine levels and protecting patients from atherosclerosis. However, as this therapy induces significant alterations in both plasma and erythrocyte membrane lipid profiles, plasma lipid values should be controlled throughout the treatment of patients with renal failure.

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Omega 3 Polyunsaturated Fatty Acids Improve Endothelial Dysfunction in Chronic Renal Failure: Role of eNOS Activation and of Oxidative Stress

Nutrients ◽

10.3390/nu9080895 ◽

2017 ◽

Vol 9 (8) ◽

pp. 895 ◽

Cited By ~ 13

Author(s):

Michela Zanetti ◽

Gianluca Gortan Cappellari ◽

Davide Barbetta ◽

Annamaria Semolic ◽

Rocco Barazzoni

Keyword(s):

Oxidative Stress ◽

Fatty Acids ◽

Renal Failure ◽

Chronic Renal Failure ◽

Endothelial Dysfunction ◽

Polyunsaturated Fatty Acids ◽

Omega 3

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The Effect of n-3 Polyunsaturated Fatty Acids on Plasma Lipids and Lipoproteins in Patients With Chronic Renal Failure—A Meta-Analysis of Randomized Controlled Trials

Journal of Renal Nutrition ◽

10.1053/j.jrn.2012.04.005 ◽

2012 ◽

Vol 22 (6) ◽

pp. 525-532 ◽

Cited By ~ 14

Author(s):

Jiao Pei ◽

Yiyang Zhao ◽

Lujiao Huang ◽

Xingyu Zhang ◽

Yang Wu

Keyword(s):

Fatty Acids ◽

Renal Failure ◽

Chronic Renal Failure ◽

Polyunsaturated Fatty Acids ◽

Randomized Controlled Trials ◽

Plasma Lipids ◽

Meta Analysis ◽

Controlled Trials ◽

Randomized Controlled ◽

Lipids And Lipoproteins

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The Influence of Fatty Acids on Thyroxine and 3, 3'-Diiodothyronine Levels in Patients with Chronic Renal Failure on Hemodialysis

Folia Endocrinologica Japonica ◽

10.1507/endocrine1927.58.2_122 ◽

1982 ◽

Vol 58 (2) ◽

pp. 122-130

Author(s):

Mitsushige NISHIKAWA ◽

Yasuo MASHIO ◽

Kiyoshi TANAKA ◽

Hitoshi ISHII ◽

Koichi NAITO ◽

...

Keyword(s):

Fatty Acids ◽

Renal Failure ◽

Chronic Renal Failure

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Lipid abnormalities of erythrocyte membranes in hemodialysis patients with chronic renal failure

Clinica Chimica Acta ◽

10.1016/0009-8981(96)06317-6 ◽

1996 ◽

Vol 252 (2) ◽

pp. 137-145 ◽

Cited By ~ 15

Author(s):

Hidetoshi Hashimoto ◽

Takaya Mio ◽

Kimiaki Sumino

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Hemodialysis Patients ◽

Erythrocyte Membranes ◽

Lipid Abnormalities

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Omega 3 Fatty Acids Effect on the Vascular Calcification Biomarkers Fetuin A and Osteoprotegerin in Hemodialysis Patients.

10.21203/rs.3.rs-392860/v1 ◽

2021 ◽

Author(s):

Rehab H. Werida ◽

Sohaila Abou-Madawy ◽

Mohamed Abdelsalam ◽

Maged Helmy

Keyword(s):

Fatty Acids ◽

Renal Failure ◽

Chronic Renal Failure ◽

Vascular Calcification ◽

Standard Care ◽

Hemodialysis Patients ◽

Control Group ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Fetuin A

Abstract Chronic Renal failure patients on dialysis are at a high risk of death due to vascular calcification (VC). This study aimed at investigating the effect of omega3- fatty acids on the vascular calcification biomarkers fetuin-A and Osteoprotegerin (OPG) in patients with chronic renal failure (CRF) who are undergoing hemodialysis. This prospective, open-label, controlled, parallel study included 60 hemodialysis patients who were randomized to receive either omega-3 fatty acids capsule along with their standard care of treatment (omega-3 group) or their standard care of treatment only (control group). Serum levels of fetuin-A, OPG, calcium, phosphorus, hemoglobin, parathyroid hormone (PTH), blood urea nitrogen (BUN), albumin (ALB), serum creatinine (SCr), and serum triglycerides (TG) were measured at baseline and after six months of intervention and follow-up of both groups. Significantly increased levels of fetuin-A and OPG (p<0.001) were observed in the omega-3 group six months after the intervention compared with the control group. Levels of calcium, phosphorous, hemoglobin, parathyroid hormone, BUN, albumin, SCr, and TG were not significantly changed in the omega-3 group or the control group after six months of intervention. Our study concluded that omega-3 may have a clinically beneficial effect in decreasing cardiovascular events by increasing the levels of the protective vascular calcification inhibitors fetuin-A and osteoprotegerin in chronic renal failure patients who are undergoing hemodialysis.

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Concentrations of iodothyronines in serum of patients with chronic renal failure and other nonthyroidal illnesses: role of free fatty acids.

Clinical Chemistry ◽

10.1093/clinchem/33.8.1382 ◽

1987 ◽

Vol 33 (8) ◽

pp. 1382-1386 ◽

Cited By ~ 26

Author(s):

K Liewendahl ◽

S Tikanoja ◽

H Mähönen ◽

T Helenius ◽

M Välimäki ◽

...

Keyword(s):

Fatty Acids ◽

Renal Failure ◽

Chronic Renal Failure ◽

Free Fatty Acids ◽

Serum Proteins ◽

Molar Ratio ◽

Similar Degree ◽

Albumin Concentration ◽

The Mean ◽

Mean Concentration

Abstract The mean concentration of free thyroxin (FT4) in serum, as determined by direct equilibrium dialysis, was decreased in patients with chronic renal failure (CRF) and increased in patients with various other nonthyroidal illnesses (NTI). The mean concentration of dialyzable free triiodothyronine (FT3) in serum was equally low in both groups of patients. Patients with CRF of various etiology but a similar degree of renal failure as estimated from serum creatinine assay had very similar concentrations of FT4 and FT3 in their serum. Mean thyroxin (T4) and triiodothyronine (T3) concentrations in serum were decreased in CRF and NTI, whereas the mean reverse-T3 concentration in serum was normal in CRF and increased in NTI. T4-binding globulin and albumin were markedly decreased in CRF and NTI; T4-binding prealbumin was increased in CRF and decreased in NTI. The mean concentration of nonesterified free fatty acids (FFA) in serum was increased in NTI but not in CRF. The weak, but significant, positive correlation observed between FT4 and FFA in serum (r = 0.34, P less than 0.01) in NTI indicates that the increase in serum FT4 in this group of patients could be an effect, at least in part, of FFA competing with T4 for binding sites on serum proteins. The stronger correlation detected between the serum FT4 concentration and the FFA/albumin molar ratio in serum (r = 0.60, P less than 0.001) demonstrates the importance of a low albumin concentration for expression of the effect of FFA on FT4 in severe systemic illnesses.

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