Childhood trauma and the severity of past suicide attempts in outpatients with cocaine use disorders

Childhood trauma is highly prevalent in patients with bipolar disorder (BD) and has been associated to a more severe/complex expression of the disorder. Little is known about the familial and individual factors that can mediate the occurrence of trauma within families but also influence the outcomes of BD. We will present data from two independent samples of patients with BD in order to identify the potential mediators for occurrence and severity/complexity. In a first sample of 371 patients with BD, 256 relatives and 157 healthy controls, we will show that there is a familial resemblance for emotional and physical abuses. Patients’ level of physical abuse was associated with their parental levels of physical abuse, but also with their father's history of alcohol misuse (p < 0.05). Second, in a sub-sample of 270 normothymic patients, we have performed a path-analysis to demonstrate that emotional and physical abuses interacted with cannabis misuse to increase the frequency of psychotic features and delusional beliefs. Finally, in an independent sample of 485 euthymic patients from the FACE-BD cohort we used path-analytic models to show that emotional abuse increased all the assessed affective/impulsive dimensions (p < 0.001). In turn, affect intensity and attitudinal hostility were associated with high risk for suicide attempts (p < 0.001), whereas impulsivity was associated with a higher risk for presence of substance misuse (p < 0.001). These results illustrate that childhood trauma might derive from parental characteristics (own childhood trauma and psychopathology) and increase the severity/complexity of BD through individual dimensions of psychopathology.Disclosure of interestThe author has not supplied his declaration of competing interest.

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The relation of childhood trauma to suicide ideation in patients suffering from obsessive-compulsive disorder with lifetime suicide attempts

Psychiatry Research ◽

10.1016/j.psychres.2017.05.032 ◽

2017 ◽

Vol 255 ◽

pp. 139-145 ◽

Cited By ~ 21

Author(s):

Vahid Khosravani ◽

Zoleikha Kamali ◽

Razieh Jamaati Ardakani ◽

Mehdi Samimi Ardestani

Keyword(s):

Obsessive Compulsive Disorder ◽

Childhood Trauma ◽

Suicide Ideation ◽

Suicide Attempts ◽

Obsessive Compulsive ◽

Compulsive Disorder

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Associations of Discrimination, Suicide Ideation Severity and Attempts, and Depressive Symptoms Among Sexual and Gender Minority Youth

Crisis ◽

10.1027/0227-5910/a000718 ◽

2020 ◽

pp. 1-8

Author(s):

Adeline Wyman Battalen ◽

Ethan Mereish ◽

Jennifer Putney ◽

Christina M. Sellers ◽

Melinda Gushwa ◽

...

Keyword(s):

Depressive Symptoms ◽

Suicidal Ideation ◽

Childhood Trauma ◽

Suicide Ideation ◽

Suicide Attempts ◽

Thwarted Belongingness ◽

Perceived Burdensomeness ◽

Sociodemographic Variables ◽

Sexual And Gender Minority ◽

And Gender

Abstract. We examined the unique associations among discrimination, suicidal thoughts, suicide attempts, and depressive symptoms in a sample of sexual and gender minority (SGM) youth as well as interpersonal mediators of these associations. Participants included 94 SGM youth ( Mage = 18; SD = 2.88) recruited from SGM-specific drop-in centers. We used mediation analyses to test the mediating effects of perceived burdensomeness and thwarted belongingness on the associations between discrimination and suicidal ideation, suicide attempts, and depressive symptoms, accounting for childhood trauma and sociodemographic variables (age, gender identity, race, and sexual orientation). Within our nonclinical community sample of SGM youth, 49% reported a lifetime suicide attempt, 84% reported current suicide ideation, and 82% reported current depressive symptoms. Experiencing discrimination was associated with greater likelihood of suicide attempts and depressive symptoms, and greater perceived burdensomeness and thwarted belongingness, over and above the effects of childhood trauma and sociodemographic variables. Discrimination was indirectly associated with greater depressive symptoms through perceived burdensomeness and thwarted belongingness, and with greater severity of suicidal ideation through perceived burdensomeness. Findings suggest clinicians should assess for discrimination and include a focus on perceived burdensomeness and thwarted belongingness as targets of intervention for suicide and depression.

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Body dysmorphic disorder in patients with borderline personality disorder: prevalence, clinical characteristics, and role of childhood trauma

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2007.00231.x ◽

2008 ◽

Vol 20 (1) ◽

pp. 33-40 ◽

Cited By ~ 15

Author(s):

Umit Semiz ◽

Cengiz Basoglu ◽

Mesut Cetin ◽

Servet Ebrinc ◽

Ozcan Uzun ◽

...

Keyword(s):

Borderline Personality Disorder ◽

Personality Disorder ◽

Childhood Trauma ◽

Body Dysmorphic Disorder ◽

Rating Scale ◽

Suicide Attempts ◽

Borderline Personality ◽

Clinical Interview ◽

Traumatic Experiences ◽

Axis I

Objective:The prevalence of body dysmorphic disorder (BDD) in patients with borderline personality disorder (BPD) is unidentified. We hypothesised that BDD would be more common than realised in patients with BPD and comorbidity with BDD would result in a more severe clinical profile. Also, childhood trauma may play a predictive role in this association.Methods:The study included 70 BPD in-patients and 70 matched healthy controls. The subjects were evaluated with a comprehensive assessment battery using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II) diagnostic tool for BDD, Global Assessment of Functioning, Traumatic Experiences Checklist and Hamilton Depression Rating Scale.Results:The prevalence of BDD was 54.3% in the borderline sample. The BPD patients with BDD had significantly lower overall functioning and higher levels of BPD pathology, childhood traumatic experiences, suicide attempts, substance abuse and self-mutilation than those without BDD. Traumatic experiences were significant predictor of comorbid BDD diagnosis in BPD patients.Conclusions:Our results suggest a relatively high prevalence of BDD among patients with BPD, and co-occurrence of BDD and BPD remains to be clarified. The additional diagnosis of BDD in patients with BPD may cause a more severe global illness, and these two disorders may share, at least partly, a common psychopathologic mechanism.

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Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder

Frontiers in Human Neuroscience ◽

10.3389/fnhum.2018.00051 ◽

2018 ◽

Vol 12 ◽

Cited By ~ 4

Author(s):

Keren Bachi ◽

Muhammad A. Parvaz ◽

Scott J. Moeller ◽

Gabriela Gan ◽

Anna Zilverstand ◽

...

Keyword(s):

Childhood Trauma ◽

Gray Matter ◽

Cocaine Use ◽

Matter Concentration

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Childhood trauma and psychosis - what is the evidence?

Dialogues in Clinical Neuroscience ◽

10.31887/dcns.2011.13.2/ischaefer ◽

2011 ◽

Vol 13 (3) ◽

pp. 360-365 ◽

Cited By ~ 23

Keyword(s):

Childhood Trauma ◽

Suicide Attempts ◽

Population Based ◽

Psychotic Symptoms ◽

Post Traumatic Stress ◽

History Of Childhood ◽

Wide Range ◽

History Of ◽

Negative Perceptions ◽

Increased Sensitivity

In the last decade, a substantial number of population-based studies have suggested that childhood trauma is a risk factor for psychosis. In several studies, the effects held after adjusting for a wide range of potentially confounding variables, including genetic liability for psychosis. Less is known about the mechanisms underlying the association between childhood trauma and psychosis. Possible pathways include relationships between negative perceptions of the self, negative affect, and psychotic symptoms, as well as biological mechanisms such as dysregulated cortisol and increased sensitivity to stress. Psychotic patients with a history of childhood trauma tend to present with a variety of additional problems, including post-traumatic stress disorder, greater substance abuse, higher levels of depression and anxiety, and more frequent suicide attempts. Initial studies suggest that trauma-specific treatments are as beneficial for these patients as for other diagnostic groups.

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