scholarly journals Eosinophils in patients suffering from atopic dermatitis and the relation to the occurrence of food allergy and other atopic diseases

2016 ◽  
Vol 27 (5) ◽  
pp. 700-710 ◽  
Author(s):  
J. Čelakovská ◽  
J. Bukač
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Atopic Diseases

O Uso dos Probióticos nas Doenças Alérgicas: Revisão de Literatura/The Use of Probiotics on Allergic Diseases: Literature Review

1970 ◽  
Vol 4 (2) ◽  
pp. 108-119
Author(s):  
Isabela Maria Anselmo Ribeiro Simões ◽  
Helba Heliane Toledo ◽  
José Henrique Pereira Pinto
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Literature Review ◽  
Scientific Community ◽  
Allergic Diseases ◽  
Progressive Increase ◽  
Atopic Diseases ◽  
Significant Clinical Improvement ◽  
Probiotic Strains

Nas últimas décadas, observou-se o aumento progressivo das doenças alérgicas e assim, novas alternativas preventivas e de tratamento têm sido buscadas. Neste âmbito, é notável o crescimento no número de pesquisas na comunidade científica destinadas a investigar se a suplementação com substancias probióticas seria capaz de reduzir a incidência e severidade das atopias clínicas, bem como seus possíveis efeitos como estratégia de tratamento. O artigo consistiu em uma revisão bibliográfica com o objetivo de analisar a eficácia dos probióticos nas atopias clínicas como asma, rinite alérgica, dermatite atópica e alergia alimentar, bem como seus efeitos. Apesar de relatos consistentes apontarem que cepas probióticas específicas quando usadas em  determinados casos produzem melhora clínica significante, ainda se faz de extrema importância novos estudos, visando verificar e esclarecer precisamente os demais efeitos produzidos, incluindo efeitos colaterais, determinação de uma dosagem adequada, bem como a população alvo.Palavras-chave: probióticos, alergia, hipersensibilidade. ABSTRACTIn the last decades, it was observed a progressive increase of allergic diseases and consequently researchers are looking for new preventive and alternative treatments. In this context it is remarkable the growth of researcher in the scientific community,aiming to investigate whether the supplementation with probiotics substances would be able to reduce the incidence and severity of clinical atopy and its effects as a treatment strategy. The study consisted of a literature review with the aim of evaluate the clinical efficacy of probiotics in atopic diseases such as asthma, allergic rhinitis, atopic dermatitis and food allergy as well as its effects.Despite consistent reports suggest that specific probiotic strains when used in certain cases produce significant clinical improvement, it is still extremely important to have new studies in order to verify and clarify precisely other effects, including side effects, the appropriate dosage as well as the target population.Keywords: probiotics, allergy, hypersensitivity.

scholarly journals Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Alyssa Sweeney ◽  
Vanitha Sampath ◽  
Kari C. Nadeau
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Allergic Sensitization ◽  
Skin Barrier ◽  
Atopic Disease ◽  
Underlying Mechanism ◽  
Population Characteristics ◽  
Preventive Strategy ◽  
Atopic Diseases ◽  
Barrier Dysfunction

Abstract Background Atopic diseases, such as atopic dermatitis (AD) and food allergy (FA), have increased in prevalence in industrialized countries during the past few decades and pose a significant health burden. They appear to have a common underlying mechanism and a natural disease progression. AD is generally the first atopic disease to manifest followed by other atopic diseases, such as FA, allergic rhinitis, or allergic asthma suggesting that they are likely different manifestations of the same disease. Body Evidence suggests that allergic sensitization occurs through an impaired skin barrier, while consumption of these foods at an early age may actually result in tolerance. This has been termed the Dual-Allergen-Exposure hypothesis. Loss of barrier integrity has been hypothesized to enable penetration of allergens, pollutants, and microbes and initiation of an inflammatory immune cascade of events leading to sensitization. The immune dysfunction is thought to further exacerbate the impaired skin barrier to form a vicious cycle. There is much interest in preventing or protecting the skin barrier from developing a proinflammatory atopic state, which may potentially lead to the development of AD and subsequently, FA. Conclusion Research on preventing or treating skin barrier dysfunction is ongoing. A number of studies have evaluated the efficacy of emollients in preventing AD and FA with mixed results. Studies have differed in the study design, population characteristics, emollients type, and frequency, duration, and area of application. Emollient type has varied widely from oils, creams, petrolatum-based lotions, and trilipid creams. Current research is directed towards the use of trilipid emollients that are similar to the skin’s natural lipid composition with a 3:1:1 ratio of ceramides, cholesterol and free fatty acids and a pH that is similar to that of skin to determine their effectiveness for skin barrier repair and prevention of AD and FA.

scholarly journals A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1682
Author(s):  
Ewa Łoś-Rycharska ◽  
Marcin Gołębiewski ◽  
Marcin Sikora ◽  
Tomasz Grzybowski ◽  
Marta Gorzkiewicz ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Gut Microbiota ◽  
Bacterial Species ◽  
Rrna Gene ◽  
Healthy Children ◽  
Skin Microbiota ◽  
Fecal Samples ◽  
Healthy Infants ◽  
Α Diversity

The gut microbiota in patients with food allergy, and the skin microbiota in atopic dermatitis patients differ from those of healthy people. We hypothesize that relationships may exist between gut and skin microbiota in patients with allergies. The aim of this study was to determine the possible relationship between gut and skin microbiota in patients with allergies, hence simultaneous analysis of the two compartments of microbiota was performed in infants with and without allergic symptoms. Fifty-nine infants with food allergy and/or atopic dermatitis and 28 healthy children were enrolled in the study. The skin and gut microbiota were evaluated using 16S rRNA gene amplicon sequencing. No significant differences in the α-diversity of dermal or fecal microbiota were observed between allergic and non-allergic infants; however, a significant relationship was found between bacterial community structure and allergy phenotypes, especially in the fecal samples. Certain clinical conditions were associated with characteristic bacterial taxa in the skin and gut microbiota. Positive correlations were found between skin and fecal samples in the abundance of Gemella among allergic infants, and Lactobacillus and Bacteroides among healthy infants. Although infants with allergies and healthy infants demonstrate microbiota with similar α-diversity, some differences in β-diversity and bacterial species abundance can be seen, which may depend on the phenotype of the allergy. For some organisms, their abundance in skin and feces samples may be correlated, and these correlations might serve as indicators of the host’s allergic state.

scholarly journals Food sensitization rate and immediate-type food allergy incidence among infantile atopic dermatitis

2018 ◽  
Vol 141 (2) ◽  
pp. AB162
Author(s):  
Yuki Ejiri ◽  
Tetsuharu Manabe ◽  
Noriyuki Yanagida ◽  
Sakura Sato ◽  
Motohiro Ebisawa
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Sensitization Rate ◽  
Food Sensitization
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