O Uso dos Probióticos nas Doenças Alérgicas: Revisão de Literatura/The Use of Probiotics on Allergic Diseases: Literature Review

1970 ◽  
Vol 4 (2) ◽  
pp. 108-119
Author(s):  
Isabela Maria Anselmo Ribeiro Simões ◽  
Helba Heliane Toledo ◽  
José Henrique Pereira Pinto
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Literature Review ◽  
Scientific Community ◽  
Allergic Diseases ◽  
Progressive Increase ◽  
Atopic Diseases ◽  
Significant Clinical Improvement ◽  
Probiotic Strains

Nas últimas décadas, observou-se o aumento progressivo das doenças alérgicas e assim, novas alternativas preventivas e de tratamento têm sido buscadas. Neste âmbito, é notável o crescimento no número de pesquisas na comunidade científica destinadas a investigar se a suplementação com substancias probióticas seria capaz de reduzir a incidência e severidade das atopias clínicas, bem como seus possíveis efeitos como estratégia de tratamento. O artigo consistiu em uma revisão bibliográfica com o objetivo de analisar a eficácia dos probióticos nas atopias clínicas como asma, rinite alérgica, dermatite atópica e alergia alimentar, bem como seus efeitos. Apesar de relatos consistentes apontarem que cepas probióticas específicas quando usadas em  determinados casos produzem melhora clínica significante, ainda se faz de extrema importância novos estudos, visando verificar e esclarecer precisamente os demais efeitos produzidos, incluindo efeitos colaterais, determinação de uma dosagem adequada, bem como a população alvo.Palavras-chave: probióticos, alergia, hipersensibilidade. ABSTRACTIn the last decades, it was observed a progressive increase of allergic diseases and consequently researchers are looking for new preventive and alternative treatments. In this context it is remarkable the growth of researcher in the scientific community,aiming to investigate whether the supplementation with probiotics substances would be able to reduce the incidence and severity of clinical atopy and its effects as a treatment strategy. The study consisted of a literature review with the aim of evaluate the clinical efficacy of probiotics in atopic diseases such as asthma, allergic rhinitis, atopic dermatitis and food allergy as well as its effects.Despite consistent reports suggest that specific probiotic strains when used in certain cases produce significant clinical improvement, it is still extremely important to have new studies in order to verify and clarify precisely other effects, including side effects, the appropriate dosage as well as the target population.Keywords: probiotics, allergy, hypersensitivity.

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

scholarly journals Clinical manifestations of atopy in children up to two years of age

2011 ◽  
Vol 68 (8) ◽  
pp. 690-695 ◽  
Author(s):  
Nevenka Ilic ◽  
Vesna Velickovic ◽  
Dragoljub Djokic ◽  
Nebojsa Rankovic ◽  
Gordana Kostic ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Developed Countries ◽  
Specific Ige ◽  
Food Allergies ◽  
Atopic Diseases ◽  
Ige Antibodies ◽  
Total Ige

Background/Aim. Atopic diseases such as atopic dermatitis, allergic rhinitis and asthma have had increased prevalence during the past decade and nowadays occur in every third child in developed countries. The aim of the study was to determine frequency and type of atopic diseases at the age of two, as well as the importance the total IgE antibodies concentrations have in diagnosis and prognosis of the disease. Methods. The study involved 175 children up to two years of age. Allergy-like symptoms were found after surveying their parents and pediatric medical records. Using the fluorescence immunossay (FIA) method, total IgE antibodies concentrations and specific IgE antibodies (Phadiatop infant) were determined on an Immunocap 100 Dyagnostic System. Results. One or more allergy-like symptoms accounted for 57.7% of findings in children under the age of two, whilst in 19.4% the existence of IgE-related allergic diseases was found. Atopic diseases usually have clinical manifestations of atopic dermatitis (11.4%), IgE-bound wheezing/asthma (10.8%) and food allergies (7.4%), and to much lesser extent those of allergic rhinitis (3.4%) and urticaria (1.7%). The significantly higher total IgE antibodies concentrations were found in children with allergy-like symptoms (p < 0.0005) (cut-off 15.15 kU/L, sensitivity 76.5% specificity 71.6%). Conclusion. Almost 20% of two-year-old children have any of clinically manifested allergic diseases, with atopic dermatitis and IgE wheeze/asthma being predominant. The higher total IgE antibodies concentration is a good marker for sensitization in children with allergy-like symptoms.

Kawasaki Disease and Atopic Diseases: A Systematic Review and Meta-Analysis of Observational Studies

2021 ◽  
pp. 1-9
Author(s):  
Zihan Wang ◽  
Jintao Zhang ◽  
Hao Yan ◽  
Liang Dong
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Kawasaki Disease ◽  
Observational Studies ◽  
Allergic Conjunctivitis ◽  
Meta Analysis ◽  
Allergic Diseases ◽  
Cardiovascular Disorder ◽  
Atopic Diseases ◽  
Cross Sectional

<b><i>Introduction:</i></b> The etiology of Kawasaki disease (KD), an inflammatory and cardiovascular disorder, remains largely unexplained after more than 50 years of intensive research. In recent years, the association between KD and atopic diseases had been explored by some observational studies. We systematically reviewed and summarized the literature on the relationship between KD and atopic diseases. <b><i>Methods:</i></b> MEDLINE and EMBASE were searched to identify observational studies on the association between KD and atopic diseases from inception to May 2021. Odds ratio (OR) was pooled using random-effects models. Heterogeneity was assessed using the <i>I</i><sup>2</sup> and Cochran Q statistics. Primary outcomes were to compare the prevalence of KD among individuals with atopic diseases to nonatopic disease controls and the prevalence of atopic diseases among individuals with KD to non-KD controls. <b><i>Results:</i></b> Thirteen studies, including 12,651 cases and 170,708 controls, were included in this meta-analysis. In cross-sectional studies, KD was associated with allergic rhinitis (<i>n</i> = 6; OR, 1.69; 95% CI, 1.52–1.87), asthma (<i>n</i> = 3; OR, 1.72; 95% CI, 1.38–2.14), allergic conjunctivitis (<i>n</i> = 2; OR, 1.95; 95% CI, 1.68–2.27), and atopic dermatitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.22–1.49). In case-control and cohort studies, KD was associated with allergic rhinitis (<i>n</i> = 3; OR, 1.35; 95% CI, 1.28–1.43), asthma (<i>n</i> = 8; OR, 1.40; 95% CI, 1.19–1.65), allergic conjunctivitis (<i>n</i> = 1; OR, 1.74; 95% CI, 1.45–2.09), and atopic dermatitis (<i>n</i> = 3; OR, 1.39; 95% CI, 1.26–1.53). <b><i>Conclusion:</i></b> KD diagnosed was associated with four common atopic diseases. Among the four allergic diseases, allergic conjunctivitis and asthma have the highest correlation with KD, which may provide a direction for exploring the etiology of KD.

scholarly journals Prevalence of bronchial asthma, allergic rhinitis, atopic dermatitis in children in Lesnoy area of Sverdlovsk region

2012 ◽  
Vol 9 (3) ◽  
pp. 14-17
Author(s):  
N A Volkova ◽  
E K Beltyukov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Age Groups ◽  
International Study ◽  
Allergic Diseases ◽  
Preschool Age ◽  
Atopic Diseases ◽  
Younger Age ◽  
Further Development

A research of prevalence of allergic diseases in children from 0 to 6 years has been carried out using a standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC) in town Lesnoy in 2010. Background. To define the prevalence and structure of atopic diseases in different age groups in children of preschool age in town Lesnoy. Methods. Standardized program «International Study of Asthma and Allergies in Childhood» (ISAAC). Results. Formation of atopic march is defined, in early age — atopic dermatitis and later respiratory form of allergy. Conclusion. Treatment of atopic dermatitis as risk factor of further development of allergic rhinitis and bronchial asthma can promote preventive maintenance of respiratory forms of allergy in children of younger age.

scholarly journals APPLICATION OF VITAMIN D IN DIFFERENT DOSAGE TO TREAT CHILDREN WITH ALLERGIC DISEASES

2020 ◽  
Vol 73 (7) ◽  
pp. 1377-1383
Author(s):  
Olexandra V. Tiazhka ◽  
Zoriana V. Selska
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Vitamin D3 ◽  
Allergic Diseases ◽  
Acute Disease ◽  
Disease Remission ◽  
Significant Difference ◽  
Different Doses

The aim: To study the dynamics of the level of 25(ОН)D, ІL-4, ІL-10, and IgG in the blood serum of children with allergic diseases and to study the clinical effect of vitamin D3 administration n different dosage in this category of patients. Materials and methods: 153 children aged 3-16 with such allergic diseases as bronchial asthma, atopic dermatitis and allergic rhinitis have been examined. The level of 25(ОН) D was determined using the electrochemiluminescence method, while the levels of ІL-4, ІL-10 and IgG were assessed using enzyme-linked immunoassay. Results: In the contrasting of the initial level of 25(ОН)D in the blood serum of patients after administration of 2,000 IU of vitamin D3 over 2 months, after summer and after treatment with cholecalciferol in higher doses (4,000–5,000 IU) over 2 months, significant difference was established between the indicators by the Friedman criterion (λ2 = 41.211; P < 0.05). In the similar contrasting of ІL-4 indicators, a significant difference between them was traced (P < 0.05) in the period of acute disease as well as the downward tendency in the period of remission. In the similar contrasting of ІL-10 indicators, a significant difference between them was traced (P < 0.05) in the acute period and in the period of disease remission. In the similar contrasting of IgG indicators, a downward tendency was traced in the period of acute disease and significant decrease (P < 0.05) – in the period of disease remission. In the contrasting of 25(ОН)D and ІL-4, ІL-10 figures a strong reverse correlation relationship was traced. The therapeutic effect of the administration of vitamin D3 medication in different doses in children with allergic diseases was traced. Conclusions: The data obtained shows that in the treatment of children with bronchial asthma, allergic rhinitis and atopic dermatitis the complex therapy should include vitamin D3 medications in different doses within a long-term course of treatment.

scholarly journals Сolloidal silicon dioxide use (Polisorb MP) at food allergy skin and gastrointestinal manifestations

2021 ◽  
pp. 158-164
Author(s):  
Vera P. Vavilova ◽  
Alexander M. Vavilov ◽  
Sofia A. Tsarkova ◽  
Irina A. Nechaeva ◽  
Ekaterina Iu. Burmistrova ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Abdominal Pain ◽  
Silicon Dioxide ◽  
Life Quality ◽  
Allergic Diseases ◽  
Food Allergies ◽  
Control Groups ◽  
Gastrointestinal Manifestations ◽  
Skin Manifestations

Background. At present, due to high prevalence of allergic diseases which start in early childhood, the search for new prevention and treatment methods is in great demand. Aim. To study the effectiveness of the Russian-produced enterosorbent colloidal silicon dioxide in the treatment of patients with food allergies combined with atopic dermatitis and gastrointestinal manifestations. Materials and methods. An open, randomized, comparative clinical study of the enterosorbent (colloidal silicon dioxide) effectiveness has been conducted in parallel groups of infants and preschool children with food allergy skin and gastrointestinal manifestations. The main groups (1 67 children with food allergies and atopic dermatitis skin manifestations, 3 60 children with food allergies and gastrointestinal manifestations) received, along with basic medication, colloidal silicon dioxide enterosorbent day at an age-specific dosage twice a for 1014 days. Control groups (2 60 children with food allergies and atopic dermatitis skin manifestations, 4 60 children with food allergies and gastrointestinal manifestations) did not receive enterosorbent. All children underwent a clinical, functional and laboratory status assessment, including medical records analysis, a pediatrician clinical examination, narrow specialists (allergist-immunologist) examination, laboratory and instrumental research. The treatment effectiveness was being evaluated on the 14th day after the initiation of therapy and after 30 days. The therapy effectiveness was assessed based on regression of skin syndrome clinical and gastrointestinal manifestations, intoxication syndrome and laboratory parameters (IgE, hemogram eosinophilia duration). The study was conducted from 2017 to 2019. On the basis of LLC Modern Medical Technologies Clinics (Kemerovo). Results. Therapy with colloidal silicon dioxide increases the significance of food allergy skin manifestations positive dynamics, which makes it possible to reduce the volume of medication and the duration of topical glucocorticosteroids use to 5.340.35 days, in the compared group 10.520.85 days (p=0.002). All patients with food allergy combined with atopic dermatitis in the main and control groups noted positive clinical dynamics, appearing as decrease in the skin inflammatory reaction area and intensity. However, the of colloidal silicon dioxide use accelerates skin syndrome condition normalization significantly (group 1 skin syndrome persisted in 2.92.0% after 14 days, in group 2 18.34.9%; p=0.003). Colloidal silicon dioxide use accelerates humoral immunity state normalization (IgE) and peripheral blood parameters (hemogram eosinophilia). Colloidal silicon dioxide therapy accelerates food allergy gastrointestinal manifestations positive dynamics in children. Two weeks after the sorbent therapy started, gastrointestinal tract lesions symptoms frequency is less than in patients in the compared group. Diarrhea frequency before treatment started was 48.36.5%, 45.06.4% in the compared groups. After two weeks it decreased to 6.73.2% with the Polisorb therapy and to 16.64.8% in the compared group (p=0.003). Abdominal pain was noted by patients of both groups equally often before the study began. After 2 weeks, abdominal pain was noted by ten percent 10.03.9% of patients taking colloidal silicon dioxide and 25.05.6% of the compared group (p=0.009). Conclusion. Taking into account the composition of the colloidal silicon dioxide, it makes sense to include this medication in childrens food allergies complex treatment starting from infancy, which contributes to a more rapid relief of gastrointestinal system damage symptoms, life quality improvement for children and their parents, and decrease in medication load. When using colloidal silicon dioxide in children with food allergies, a faster dynamics of disease symptoms relief (p=0.003) was noted, which allows us to conclude that it is highly effective in the treatment of allergic diseases associated with food sensitization.

scholarly journals Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review

2019 ◽  
Vol 109 (Supplement_1) ◽  
pp. 890S-934S ◽  
Author(s):  
Julie E Obbagy ◽  
Laural K English ◽  
Yat Ping Wong ◽  
Nancy F Butte ◽  
Kathryn G Dewey ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Food Allergy ◽  
Complementary Feeding ◽  
Atopic Disease ◽  
Study Data ◽  
Reverse Causality ◽  
Diet Diversity ◽  
Diagnostic Measures ◽  
Department Of Health

ABSTRACTBackgroundNutrition during infancy and toddlerhood may influence health and disease prevention across the life span. Complementary feeding (CF) starts when human milk or infant formula is complemented by other foods and beverages, beginning during infancy and continuing to age 24 mo.ObjectivesThe aim of this study was to describe systematic reviews conducted for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following question: What is the relationship between the timing of the introduction of complementary foods and beverages (CFBs), or types and amounts of CFBs consumed, and the development of food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis?MethodsThe literature was searched using 4 databases (CINAHL, Cochrane, Embase, PubMed) to identify articles published from January 1980 to February 2017 that met predetermined inclusion criteria. For each study, data were extracted and risk of bias was assessed. The evidence was qualitatively synthesized to develop a conclusion statement, and the strength of the evidence was graded.ResultsThirty-one included articles addressed the timing of CFB introduction, and 47 articles addressed the types and amounts of CFBs consumed.ConclusionsModerate evidence suggests that there is no relationship between the age at which CF first begins and the risk of developing food allergy, atopic dermatitis/eczema, or childhood asthma. Limited to strong evidence, depending on the specific food, suggests that introducing allergenic foods in the first year of life (after 4 mo) does not increase the risk of food allergy and atopic dermatitis/eczema but may prevent peanut and egg allergy. There is not enough evidence to determine a relationship between diet diversity or dietary patterns and atopic disease. Research is needed to address gaps and limitations in the evidence on CF and atopic disease, including research that uses valid and reliable diagnostic measures and accounts for key confounders and potential reverse causality.

scholarly journals Role of innate lymphoid cells in allergic diseases

2019 ◽  
Vol 40 (3) ◽  
pp. 138-145 ◽  
Author(s):  
M. Asghar Pasha ◽  
Gargi Patel ◽  
Russell Hopp ◽  
Qi Yang
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Food Allergies ◽  
Antigen Receptors ◽  
Medline Search ◽  
Allergic Disorders

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

Sign in / Sign up

Export Citation Format

Share Document